DegronMD - Q6ZVD8(PHLPP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S53F	TCGA-60-2698	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	43:47	Mutation blocking phosphorylation signal	0.6111
p.S1073G	TCGA-AD-6895	COAD	TCGA	PATPSSS	DEG_SCF_FBW7_1	1067:1073	Mutation altering degron motif	0.6993
p.S1073G	TCGA-AD-6895	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	1070:1074	Mutation altering degron motif	0.6993
p.S1073G	DO8938	COAD	ICGC	PATPSSS	DEG_SCF_FBW7_1	1067:1073	Mutation altering degron motif	0.6993
p.S1073G	DO8938	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	1070:1074	Mutation altering degron motif	0.6993
p.A1077D	TCGA-B5-A0JR	UCEC	TCGA	PATPSSS	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.2222
p.A1077D	TCGA-B5-A0JR	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.25
p.A1077D	DO41791	UCEC	ICGC	PATPSSS	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.2222
p.A1077D	DO41791	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.25
p.V1053A	TCGA-B5-A1MR	UCEC	TCGA	ASTTT	DEG_SPOP_SBC_1	1056:1060	Mutation rewiring degron network	0.25
p.V1053A	DO41758	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	1056:1060	Mutation rewiring degron network	0.25
p.V1053A	SIDM00245	Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	1056:1060	Mutation rewiring degron network	0.25
p.V1053A	ACH-001131	Skin Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	1056:1060	Mutation rewiring degron network	0.25
p.V1053A	MS-1	lung	COSMIC	ASTTT	DEG_SPOP_SBC_1	1056:1060	Mutation rewiring degron network	0.25
p.T49A	TCGA-BR-8591	STAD	TCGA	ADTTT	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1389
p.T49A	TCGA-BR-8591	STAD	TCGA	ATTTT	DEG_SPOP_SBC_1	43:47	Mutation rewiring degron network	0.2778
p.T45I	TCGA-DX-A3UC	SARC	TCGA	ATTTT	DEG_SPOP_SBC_1	43:47	Mutation altering degron motif	0.7078
p.T45I	DO219979	SARC	ICGC	ATTTT	DEG_SPOP_SBC_1	43:47	Mutation altering degron motif	0.7078
p.S55C	TCGA-FR-A7U9	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	43:47	Mutation blocking phosphorylation signal	0.5556
p.P1050L	TCGA-ZF-A9R7	BLCA	TCGA	ASTTT	DEG_SPOP_SBC_1	1056:1060	Mutation rewiring degron network	0.1667
p.R48K	DO48611	BLCA	ICGC	ADTTT	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1667
p.R48K	DO48611	BLCA	ICGC	ATTTT	DEG_SPOP_SBC_1	43:47	Mutation rewiring degron network	0.3056
p.R42I	DO447	BLCA	ICGC	ADTTT	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.8102
p.G37A	DO227935	BRCA	ICGC	ADTTT	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.3056
p.G37A	DO227935	BRCA	ICGC	ATTTT	DEG_SPOP_SBC_1	43:47	Mutation rewiring degron network	0.1667
p.P1065H	DO233612	GACA	ICGC	PATPSSS	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.2778
p.P1065H	DO233612	GACA	ICGC	ASTTT	DEG_SPOP_SBC_1	1056:1060	Mutation rewiring degron network	0.1944
p.P1065H	DO233612	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.1944
p.R38C	DO233731	GACA	ICGC	ADTTT	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.8301
p.D57E	DO228974	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	43:47	Mutation rewiring degron network	0.0556
p.P1070Q	DO229038	LICA	ICGC	PATPSSS	DEG_SCF_FBW7_1	1067:1073	Mutation altering degron motif	0.7035
p.P1070Q	DO229038	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	1070:1074	Mutation altering degron motif	0.7035
p.A1064D	DO229045	LICA	ICGC	PATPSSS	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.25
p.A1064D	DO229045	LICA	ICGC	ASTTT	DEG_SPOP_SBC_1	1056:1060	Mutation rewiring degron network	0.2222
p.A1064D	DO229045	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.1667
p.N39K	DO32616	OV	ICGC	ADTTT	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.6918
p.R47S	DO37627	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	43:47	Mutation altering degron motif	0.7427
p.N35H	DO50076	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.25
p.N35H	DO50076	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	43:47	Mutation rewiring degron network	0.1111
p.L1049V	SIDM00613	Glioblastoma	GDSC	ASTTT	DEG_SPOP_SBC_1	1056:1060	Mutation rewiring degron network	0.1389
p.L1049V	KALS-1	central nervous system	COSMIC	ASTTT	DEG_SPOP_SBC_1	1056:1060	Mutation rewiring degron network	0.1389
p.E1079D	SIDM00736	Non-Cancerous	GDSC	PATPSSS	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.1667
p.E1079D	SIDM00736	Non-Cancerous	GDSC	PSSSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.1944
p.L1084V	KALS-1	central nervous system	COSMIC	PSSSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.0556
p.S53C	Set2	haematopoietic and lymphoid tissue	COSMIC	ATTTT	DEG_SPOP_SBC_1	43:47	Mutation blocking phosphorylation signal	0.6111
p.M1064L	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PATPSSS	DEG_SCF_FBW7_1	1067:1073	Mutation rewiring degron network	0.25
p.M1064L	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	ASTTT	DEG_SPOP_SBC_1	1056:1060	Mutation rewiring degron network	0.2222
p.M1064L	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	1070:1074	Mutation rewiring degron network	0.1667

Kaplan plot for PHLPP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHLPP2

UniProt ID: Q6ZVD8

Entrez ID: 23035

Protein name: PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHLPP2 in