DegronMD

Uniprot ID: Q6ZVD8

Source protein: PH domain leucine-rich repeat-containing protein phosphatase 2

Source gene: PHLPP2

Class: DEG_SPOP_SBC_1

Location: 38:42

E3 ligase: SPOP

DEGRON score: 0.9983

ASA_SCORE: 77.88

COIL: 0.9148

CONS_SCORE: 0.287

DSS_SCORE: 0.3313

HELIX: 0.0418

FCONS_SCORE: 1.0328

RIG_SCORE: 0.7844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T49A	TCGA-BR-8591	STAD	TCGA	ADTTT	DEG_SPOP_SBC_1	0.1389
p.R48K	DO48611	BLCA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1667
p.R42I	DO447	BLCA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.8102
p.G37A	DO227935	BRCA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.3056
p.R38C	DO233731	GACA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.8301
p.N39K	DO32616	OV	ICGC	ADTTT	DEG_SPOP_SBC_1	0.6918
p.N35H	DO50076	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	129:133	ADTTT	SPOP	0.8638	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	292:296	ADTTT	SPOP	0.9991	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	283:287	ADTTT	SPOP	0.9945	More...
P39060	Collagen alpha-1	DEG_SPOP_SBC_1	58:62	ADTTT	SPOP	0.8165	More...
Q15059	Bromodomain-containing protein 3	DEG_SPOP_SBC_1	246:250	ADTTT	SPOP	0.9976	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	215:219	ADTTT	SPOP	0.9952	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	38:42	ADTTT	SPOP	0.9983	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	667:671	ADTTT	SPOP	0.9939	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	251:255	ADTTT	SPOP	0.9047	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons