DegronMD - Q15059(BRD3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G241S	TCGA-76-4934	GBM	TCGA	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1944
p.G241S	DO12286	GBM	ICGC	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1944
p.R244L	TCGA-78-7540	LUAD	TCGA	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.2778
p.R244L	DO23810	LUAD	ICGC	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.2778
p.A197S	TCGA-95-7043	LUAD	TCGA	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation altering degron motif	0.6477
p.A197S	DO24739	LUAD	ICGC	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation altering degron motif	0.6477
p.S448L	TCGA-AP-A1E0	UCEC	TCGA	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.3056
p.S448L	DO43154	UCEC	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.3056
p.R244Q	TCGA-AX-A2HA	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.2778
p.R244Q	DO42504	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.2778
p.R244Q	SIDM00999	Bladder Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.2778
p.R244Q	ACH-000973	Bladder Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.2778
p.R244Q	639-V	urinary tract	COSMIC	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.2778
p.A546V	TCGA-AX-A2HJ	UCEC	TCGA	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.2778
p.A546V	DO42105	UCEC	ICGC	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.2778
p.A464V	TCGA-AX-A3FS	UCEC	TCGA	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.0833
p.A464V	DO40879	UCEC	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.0833
p.A464V	DO41199	UCEC	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.0833
p.S175P	TCGA-B5-A11E	UCEC	TCGA	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.2222
p.S175P	DO41644	UCEC	ICGC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.2222
p.A180V	TCGA-B5-A3FC	UCEC	TCGA	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation altering degron motif	0.5825
p.A180V	DO41871	UCEC	ICGC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation altering degron motif	0.5825
p.V171L	TCGA-B9-5155	KIRP	TCGA	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.1111
p.V171L	DO20843	KIRP	ICGC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.1111
p.E444G	TCGA-BS-A0UJ	UCEC	TCGA	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.1944
p.E444G	DO42745	UCEC	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.1944
p.R441H	TCGA-DU-6392	LGG	TCGA	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.1111
p.R441H	DO222492	COCA	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.1111
p.R441H	DO22237	LGG	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.1111
p.R441H	SIDM00190	Melanoma	GDSC	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.1111
p.R441H	SIDM01715	Non-Cancerous	GDSC	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.1111
p.N541I	TCGA-DV-A4W0	KIRC	TCGA	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation altering degron motif	0.6169
p.N541I	DO219235	KIRC	ICGC	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation altering degron motif	0.6169
p.S175F	TCGA-ER-A19W	SKCM	TCGA	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.2222
p.S175F	DO50300	SKCM	ICGC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.2222
p.F551I	DO50439	ESAD	ICGC	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation substituting flanking lysine	0.25
p.T545M	DO218031	GACA	ICGC	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.3056
p.T545M	DO218243	GACA	ICGC	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.3056
p.T461I	DO224908	LAML	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation rewiring degron network	0.1667
p.Q532K	DO228902	LICA	ICGC	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation rewiring degron network	0.1111
p.P187T	DO229028	LICA	ICGC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.2778
p.P187T	DO229028	LICA	ICGC	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.0833
p.S185R	DO229041	LICA	ICGC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation altering degron motif	0.7427
p.S452R	DO229045	LICA	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation altering degron motif	0.6316
p.P200L	DO23132	LINC	ICGC	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation altering degron motif	0.7582
p.K534R	DO228371	MALY	ICGC	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation substituting flanking lysine	0.2778
p.K534R	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation substituting flanking lysine	0.2778
p.K534R	ACH-000315	Lymphoma	CCLE	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation substituting flanking lysine	0.2778
p.P187A	DO222470	MELA	ICGC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.2778
p.P187A	DO222470	MELA	ICGC	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.0833
p.F551L	DO36881	READ	ICGC	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation substituting flanking lysine	0.25
p.T199P	DO218890	SKCA	ICGC	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation altering degron motif	0.7031
p.V190I	SIDM00781	Colorectal Carcinoma	GDSC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.1944
p.V190I	SIDM00781	Colorectal Carcinoma	GDSC	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1667
p.V190I	SIDM00780	Colorectal Carcinoma	GDSC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.1944
p.V190I	SIDM00780	Colorectal Carcinoma	GDSC	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1667
p.V190I	ACH-000967	Colon/Colorectal Cancer	CCLE	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.1944
p.V190I	ACH-000967	Colon/Colorectal Cancer	CCLE	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1667
p.V190I	ACH-001199	Colon/Colorectal Cancer	CCLE	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.1944
p.V190I	ACH-001199	Colon/Colorectal Cancer	CCLE	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1667
p.V190I	SNU-C2B	large intestine	COSMIC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.1944
p.V190I	SNU-C2B	large intestine	COSMIC	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1667
p.D247N	SIDM00767	Small Cell Lung Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation altering degron motif	0.5821
p.D247N	ACH-001136	Lung Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation altering degron motif	0.5821
p.D247N	NCI-H187	lung	COSMIC	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation altering degron motif	0.5821
p.V174M	SIDM00875	Breast Carcinoma	GDSC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.1944
p.V174M	SIDM00793	Burkitt's Lymphoma	GDSC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.1944
p.V174M	SIDM01173	Rhabdomyosarcoma	GDSC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.1944
p.P188A	SIDM00892	Breast Carcinoma	GDSC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.25
p.P188A	SIDM00892	Breast Carcinoma	GDSC	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1111
p.P188A	ACH-000818	Breast Cancer	CCLE	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.25
p.P188A	ACH-000818	Breast Cancer	CCLE	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1111
p.P188A	BT-483	breast	COSMIC	PATPFQS	DEG_SCF_FBW7_1	179:185	Mutation rewiring degron network	0.25
p.P188A	BT-483	breast	COSMIC	IAATPVPT	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1111
p.S450L	ACH-000640	Skin Cancer	CCLE	DSGSSDS	DEG_SCF_TRCP1_1	449:455	Mutation altering degron motif	0.7667
p.T544N	ACH-000917	Esophageal Cancer	CCLE	ANSTT	DEG_SPOP_SBC_1	540:544	Mutation altering degron motif	0.7055
p.S254L	ACH-001610	Brain Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	246:250	Mutation blocking phosphorylation signal	0.6667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRD3

UniProt ID: Q15059

Entrez ID: 8019

Protein name: Bromodomain-containing protein 3 (RING3-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRD3 in