DegronMD

Uniprot ID: Q15059

Source protein: Bromodomain-containing protein 3

Source gene: BRD3

Class: DEG_SCF_TRCP1_1

Location: 449:455

E3 ligase: BTRC

DEGRON score: 0.9481

ASA_SCORE: 86.2571

COIL: 0.81

CONS_SCORE: 0.354

DSS_SCORE: 0.7737

HELIX: 0.1843

FCONS_SCORE: 1.075

RIG_SCORE: 0.4682

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S448L	TCGA-AP-A1E0	UCEC	TCGA	DSGSSDS	DEG_SCF_TRCP1_1	0.3056
p.S448L	DO43154	UCEC	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	0.3056
p.A464V	TCGA-AX-A3FS	UCEC	TCGA	DSGSSDS	DEG_SCF_TRCP1_1	0.0833
p.A464V	DO40879	UCEC	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	0.0833
p.A464V	DO41199	UCEC	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	0.0833
p.E444G	TCGA-BS-A0UJ	UCEC	TCGA	DSGSSDS	DEG_SCF_TRCP1_1	0.1944
p.E444G	DO42745	UCEC	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	0.1944
p.R441H	TCGA-DU-6392	LGG	TCGA	DSGSSDS	DEG_SCF_TRCP1_1	0.1111
p.R441H	DO222492	COCA	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	0.1111
p.R441H	DO22237	LGG	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	0.1111
p.R441H	SIDM00190	Melanoma	GDSC	DSGSSDS	DEG_SCF_TRCP1_1	0.1111
p.R441H	SIDM01715	Non-Cancerous	GDSC	DSGSSDS	DEG_SCF_TRCP1_1	0.1111
p.T461I	DO224908	LAML	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	0.1667
p.S452R	DO229045	LICA	ICGC	DSGSSDS	DEG_SCF_TRCP1_1	0.6316
p.S450L	ACH-000640	Skin Cancer	CCLE	DSGSSDS	DEG_SCF_TRCP1_1	0.7667

Drug responses associated with BRD3 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01077	PRAD\|prostate	p.K435Q (No)	GDSC	JQ1	0.3976
SIDM01077	PRAD\|prostate	p.K435Q (No)	GDSC	I-BET-762	1.2888
SIDM01077	PRAD\|prostate	p.K435Q (No)	GDSC	JQ1	7.6954
SIDM01077	PRAD\|prostate	p.K435Q (No)	GDSC	I-BET-762	5.6449
SIDM01077	PRAD\|prostate	p.K435Q (No)	GDSC	OTX015	1.3879
SIDM00592	HNSC\|head_and_neck	p.T250P (No)	GDSC	JQ1	1.573
SIDM00592	HNSC\|head_and_neck	p.T250P (No)	GDSC	I-BET-762	145.0807
SIDM00592	HNSC\|head_and_neck	p.T250P (No)	GDSC	JQ1	0.7392
SIDM00592	HNSC\|head_and_neck	p.T250P (No)	GDSC	I-BET-762	7.7874
SIDM00592	HNSC\|head_and_neck	p.T250P (No)	GDSC	OTX015	2.209
SIDM00240	CESC\|cervix	p.S27C (No)	GDSC	JQ1	2.3732
SIDM00240	CESC\|cervix	p.S27C (No)	GDSC	I-BET-762	71.5862
SIDM00240	CESC\|cervix	p.S27C (No)	GDSC	JQ1	2.1327
SIDM01164	LGG\|glioma	p.R578H (No)	GDSC	JQ1	1.2267
SIDM01164	LGG\|glioma	p.R578H (No)	GDSC	I-BET-762	194.4751
SIDM01164	LGG\|glioma	p.R578H (No)	GDSC	JQ1	9.0501
SIDM01188	PAAD\|pancreas	p.P23T (No)	GDSC	JQ1	0.4647
SIDM01188	PAAD\|pancreas	p.P23T (No)	GDSC	I-BET-762	104.9952
SIDM01188	PAAD\|pancreas	p.P23T (No)	GDSC	JQ1	16.1912
SIDM01188	PAAD\|pancreas	p.P23T (No)	GDSC	I-BET-762	2146.4
SIDM01188	PAAD\|pancreas	p.P23T (No)	GDSC	OTX015	2169.4
SIDM00498	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	90.7099
SIDM00498	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	16.3879
SIDM00498	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	31.09
SIDM00498	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	OTX015	11.312
SIDM01174	CESC\|cervix	p.H550_C554delHFLTC (No)	GDSC	JQ1	4.27
SIDM01174	CESC\|cervix	p.H550_C554delHFLTC (No)	GDSC	I-BET-762	364.9685
SIDM01174	CESC\|cervix	p.H550_C554delHFLTC (No)	GDSC	JQ1	3.2888
SIDM01174	CESC\|cervix	p.H550_C554delHFLTC (No)	GDSC	I-BET-762	310.95
SIDM01174	CESC\|cervix	p.H550_C554delHFLTC (No)	GDSC	OTX015	366.53
SIDM00945	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	20.3215
SIDM00945	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	12.192
SIDM00945	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	OTX015	8.2232
SIDM00121	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	JQ1	0.295
SIDM00121	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	I-BET-762	2.3258
SIDM00121	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	JQ1	0.5738
SIDM00121	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	I-BET-762	13.928
SIDM00121	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	OTX015	8.6619
SIDM00683	PRAD\|prostate	p.V26G (No)	GDSC	JQ1	0.7789
SIDM00683	PRAD\|prostate	p.V26G (No)	GDSC	I-BET-762	2.6504
SIDM00683	PRAD\|prostate	p.V26G (No)	GDSC	JQ1	11.3018
SIDM00683	PRAD\|prostate	p.V26G (No)	GDSC	I-BET-762	2.6739
SIDM00683	PRAD\|prostate	p.V26G (No)	GDSC	OTX015	0.6869
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P24fs*24 (No)	GDSC	JQ1	0.6789
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P24fs*24 (No)	GDSC	I-BET-762	3.2635
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P24fs*24 (No)	GDSC	JQ1	0.3499
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P24fs*24 (No)	GDSC	I-BET-762	92.613
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P24fs*24 (No)	GDSC	OTX015	27.581
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.E25fs*51 (No)	GDSC	JQ1	0.6789
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.E25fs*51 (No)	GDSC	I-BET-762	3.2635
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.E25fs*51 (No)	GDSC	JQ1	0.3499
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.E25fs*51 (No)	GDSC	I-BET-762	92.613
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.E25fs*51 (No)	GDSC	OTX015	27.581
SIDM00837	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	1.1252
SIDM00837	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	21.0327
SIDM00837	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	10.556
SIDM00837	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	10.246
SIDM00837	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	OTX015	3.6348
SIDM00781	COREAD\|large_intestine	p.P24fs*51 (No)	GDSC	JQ1	1.035
SIDM00781	COREAD\|large_intestine	p.P24fs*51 (No)	GDSC	I-BET-762	11.5453
SIDM00781	COREAD\|large_intestine	p.P24fs*51 (No)	GDSC	JQ1	21.0914
SIDM00781	COREAD\|large_intestine	p.P24fs*51 (No)	GDSC	I-BET-762	22.924
SIDM00781	COREAD\|large_intestine	p.P24fs*51 (No)	GDSC	OTX015	3.8966
SIDM00334	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	0.8552
SIDM00334	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	49.7156
SIDM00334	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	12.0168
SIDM00334	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	225.8
SIDM00334	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	OTX015	363.36
SIDM00519	MESO\|mesothelioma	p.A172V (No)	GDSC	JQ1	8.7965
SIDM00519	MESO\|mesothelioma	p.A172V (No)	GDSC	I-BET-762	167.0381
SIDM00519	MESO\|mesothelioma	p.A172V (No)	GDSC	JQ1	19.234
SIDM00519	MESO\|mesothelioma	p.A172V (No)	GDSC	I-BET-762	75.068
SIDM00519	MESO\|mesothelioma	p.A172V (No)	GDSC	OTX015	68.795
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.K655R (No)	GDSC	JQ1	2.4783
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.K655R (No)	GDSC	I-BET-762	15.6496
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.K655R (No)	GDSC	JQ1	9.1283
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.K655R (No)	GDSC	I-BET-762	27.067
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.K655R (No)	GDSC	OTX015	9.8305
SIDM00781	COREAD\|large_intestine	p.V190I (No)	GDSC	JQ1	1.035
SIDM00781	COREAD\|large_intestine	p.V190I (No)	GDSC	I-BET-762	11.5453
SIDM00781	COREAD\|large_intestine	p.V190I (No)	GDSC	JQ1	21.0914
SIDM00781	COREAD\|large_intestine	p.V190I (No)	GDSC	I-BET-762	22.924
SIDM00781	COREAD\|large_intestine	p.V190I (No)	GDSC	OTX015	3.8966
SIDM00537	COREAD\|large_intestine	p.A216fs*47 (No)	GDSC	JQ1	0.3119
SIDM00537	COREAD\|large_intestine	p.A216fs*47 (No)	GDSC	I-BET-762	19.8372
SIDM00537	COREAD\|large_intestine	p.A216fs*47 (No)	GDSC	JQ1	8.9937
SIDM00537	COREAD\|large_intestine	p.A216fs*47 (No)	GDSC	I-BET-762	28.523
SIDM00537	COREAD\|large_intestine	p.A216fs*47 (No)	GDSC	OTX015	16.542
SIDM00537	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	0.3119
SIDM00537	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	19.8372
SIDM00537	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	8.9937
SIDM00537	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	28.523
SIDM00537	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	OTX015	16.542
SIDM01051	UNCLASSIFIED\|ovary	p.G717R (No)	GDSC	JQ1	0.4035
SIDM01051	UNCLASSIFIED\|ovary	p.G717R (No)	GDSC	I-BET-762	149.4508
SIDM01051	UNCLASSIFIED\|ovary	p.G717R (No)	GDSC	JQ1	13.1406
SIDM01051	UNCLASSIFIED\|ovary	p.G717R (No)	GDSC	I-BET-762	62.026
SIDM01051	UNCLASSIFIED\|ovary	p.G717R (No)	GDSC	OTX015	84.708
SIDM00666	LGG\|glioma	p.K435Q (No)	GDSC	JQ1	0.6311
SIDM00666	LGG\|glioma	p.K435Q (No)	GDSC	I-BET-762	130.1398
SIDM00666	LGG\|glioma	p.K435Q (No)	GDSC	JQ1	11.3272
SIDM00145	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	JQ1	2.3644
SIDM00145	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	I-BET-762	15.0909
SIDM00145	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	JQ1	0.3551
SIDM00145	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	I-BET-762	14.96
SIDM00145	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	OTX015	12.366
SIDM00312	MM\|myeloma	p.K435Q (No)	GDSC	JQ1	0.8435
SIDM00312	MM\|myeloma	p.K435Q (No)	GDSC	I-BET-762	5.4856
SIDM00312	MM\|myeloma	p.K435Q (No)	GDSC	JQ1	9.4619
SIDM00312	MM\|myeloma	p.K435Q (No)	GDSC	I-BET-762	6.212
SIDM00312	MM\|myeloma	p.K435Q (No)	GDSC	OTX015	2.7912
SIDM01088	UNCLASSIFIED\|endometrium	p.R284H (No)	GDSC	JQ1	1.3207
SIDM01088	UNCLASSIFIED\|endometrium	p.R284H (No)	GDSC	I-BET-762	48.995
SIDM01088	UNCLASSIFIED\|endometrium	p.R284H (No)	GDSC	JQ1	11.2727
SIDM01088	UNCLASSIFIED\|endometrium	p.R284H (No)	GDSC	I-BET-762	18.636
SIDM01088	UNCLASSIFIED\|endometrium	p.R284H (No)	GDSC	OTX015	7.414
SIDM00256	NB\|neuroblastoma	p.M383_F384delinsI (No)	GDSC	JQ1	0.3181
SIDM00256	NB\|neuroblastoma	p.M383_F384delinsI (No)	GDSC	I-BET-762	34.4825
SIDM00256	NB\|neuroblastoma	p.M383_F384delinsI (No)	GDSC	JQ1	8.7581
SIDM00256	NB\|neuroblastoma	p.M383_F384delinsI (No)	GDSC	I-BET-762	92.689
SIDM00256	NB\|neuroblastoma	p.M383_F384delinsI (No)	GDSC	OTX015	86.672
SIDM00003	SKCM\|melanoma	p.S609F (No)	GDSC	JQ1	0.3151
SIDM00003	SKCM\|melanoma	p.S609F (No)	GDSC	I-BET-762	17.5293
SIDM00003	SKCM\|melanoma	p.S609F (No)	GDSC	JQ1	21.531
SIDM00003	SKCM\|melanoma	p.S609F (No)	GDSC	I-BET-762	38.752
SIDM00003	SKCM\|melanoma	p.S609F (No)	GDSC	OTX015	7.8185
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.P266L (No)	GDSC	JQ1	6.1996
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.P266L (No)	GDSC	I-BET-762	35.822
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.P266L (No)	GDSC	JQ1	8.1248
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.P266L (No)	GDSC	I-BET-762	24.728
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.P266L (No)	GDSC	OTX015	55.321
SIDM00151	OV\|ovary	p.P24fs*24 (No)	GDSC	JQ1	22.7238
SIDM00151	OV\|ovary	p.P24fs*24 (No)	GDSC	I-BET-762	9.7528
SIDM00151	OV\|ovary	p.P24fs*24 (No)	GDSC	OTX015	3.6257
SIDM00418	THCA\|thyroid	p.K435Q (No)	GDSC	JQ1	0.2493
SIDM00418	THCA\|thyroid	p.K435Q (No)	GDSC	I-BET-762	23.9838
SIDM00418	THCA\|thyroid	p.K435Q (No)	GDSC	JQ1	13.2791
SIDM00418	THCA\|thyroid	p.K435Q (No)	GDSC	I-BET-762	30.514
SIDM00418	THCA\|thyroid	p.K435Q (No)	GDSC	OTX015	20.307
SIDM00373	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	0.8733
SIDM00373	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	112.2983
SIDM00373	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	8.3749
SIDM00373	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	90.897
SIDM00373	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	OTX015	23.288
SIDM00373	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	JQ1	0.8733
SIDM00373	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	I-BET-762	112.2983
SIDM00373	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	JQ1	8.3749
SIDM00373	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	I-BET-762	90.897
SIDM00373	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	OTX015	23.288
SIDM01259	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	JQ1	0.5022
SIDM01259	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	I-BET-762	1.8887
SIDM01259	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	JQ1	2.2668
SIDM01259	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	I-BET-762	4.003
SIDM01259	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	OTX015	1.1727
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P232H (No)	GDSC	JQ1	0.6789
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P232H (No)	GDSC	I-BET-762	3.2635
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P232H (No)	GDSC	JQ1	0.3499
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P232H (No)	GDSC	I-BET-762	92.613
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P232H (No)	GDSC	OTX015	27.581
SIDM00619	THCA\|thyroid	p.L70Q (No)	GDSC	JQ1	0.1798
SIDM00619	THCA\|thyroid	p.L70Q (No)	GDSC	I-BET-762	162.5679
SIDM00619	THCA\|thyroid	p.L70Q (No)	GDSC	JQ1	5.1804
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.V174M (No)	GDSC	JQ1	2.7961
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.V174M (No)	GDSC	I-BET-762	55.8606
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.V174M (No)	GDSC	JQ1	0.8454
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.V174M (No)	GDSC	I-BET-762	3.1806
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.V174M (No)	GDSC	OTX015	2.0707
SIDM00251	STAD\|stomach	p.P24fs*24 (No)	GDSC	JQ1	6.3107
SIDM00251	STAD\|stomach	p.P24fs*24 (No)	GDSC	I-BET-762	105.237
SIDM00251	STAD\|stomach	p.P24fs*24 (No)	GDSC	JQ1	4.1863
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.D247N (No)	GDSC	JQ1	7.5775
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.D247N (No)	GDSC	I-BET-762	66.8571
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.D247N (No)	GDSC	JQ1	14.1677
SIDM00099	MESO\|mesothelioma	p.A172V (No)	GDSC	JQ1	0.9055
SIDM00099	MESO\|mesothelioma	p.A172V (No)	GDSC	I-BET-762	71.6074
SIDM00099	MESO\|mesothelioma	p.A172V (No)	GDSC	JQ1	18.934
SIDM00099	MESO\|mesothelioma	p.A172V (No)	GDSC	I-BET-762	102.22
SIDM00099	MESO\|mesothelioma	p.A172V (No)	GDSC	OTX015	43.237
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.K435Q (No)	GDSC	JQ1	1.0155
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.K435Q (No)	GDSC	I-BET-762	221.1497
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.K435Q (No)	GDSC	JQ1	10.0186
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.K435Q (No)	GDSC	I-BET-762	30.21
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.K435Q (No)	GDSC	OTX015	13.277
SIDM00211	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	JQ1	0.3232
SIDM00211	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	I-BET-762	0.8405
SIDM00211	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	JQ1	7.5537
SIDM00211	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	I-BET-762	5.202
SIDM00211	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	OTX015	2.7833
SIDM00783	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	0.1659
SIDM00783	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	22.6909
SIDM00783	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	8.3957
SIDM00783	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	28.645
SIDM00783	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	OTX015	7.6012
SIDM00999	BLCA\|bladder	p.R244Q (No)	GDSC	JQ1	0.2974
SIDM00999	BLCA\|bladder	p.R244Q (No)	GDSC	I-BET-762	61.3936
SIDM00999	BLCA\|bladder	p.R244Q (No)	GDSC	JQ1	1.0951
SIDM00999	BLCA\|bladder	p.R244Q (No)	GDSC	I-BET-762	16.979
SIDM00999	BLCA\|bladder	p.R244Q (No)	GDSC	OTX015	21.915
SIDM00217	COREAD\|large_intestine	p.R34H (No)	GDSC	I-BET-762	20.859
SIDM00217	COREAD\|large_intestine	p.R34H (No)	GDSC	JQ1	5.699
SIDM00217	COREAD\|large_intestine	p.R34H (No)	GDSC	I-BET-762	45.177
SIDM00217	COREAD\|large_intestine	p.R34H (No)	GDSC	OTX015	13.116
SIDM00180	KIRC\|kidney	p.T36N (No)	GDSC	JQ1	1.2191
SIDM00180	KIRC\|kidney	p.T36N (No)	GDSC	I-BET-762	225.1683
SIDM00180	KIRC\|kidney	p.T36N (No)	GDSC	JQ1	13.9753
SIDM00180	KIRC\|kidney	p.T36N (No)	GDSC	I-BET-762	34.459
SIDM00180	KIRC\|kidney	p.T36N (No)	GDSC	OTX015	23.587
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.P234S (No)	GDSC	JQ1	51.5138
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.P234S (No)	GDSC	I-BET-762	182.0816
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.P234S (No)	GDSC	JQ1	12.4468
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.P234S (No)	GDSC	I-BET-762	20.848
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.P234S (No)	GDSC	OTX015	21.788
SIDM00933	BRCA\|breast	p.A172V (No)	GDSC	JQ1	3.4367
SIDM00933	BRCA\|breast	p.A172V (No)	GDSC	I-BET-762	114.2188
SIDM00933	BRCA\|breast	p.A172V (No)	GDSC	JQ1	4.869
SIDM00933	BRCA\|breast	p.A172V (No)	GDSC	I-BET-762	260.84
SIDM00933	BRCA\|breast	p.A172V (No)	GDSC	OTX015	42.102
SIDM00933	BRCA\|breast	p.A172V (No)	GDSC	JQ1	40.792
SIDM00889	CESC\|cervix	p.K435Q (No)	GDSC	JQ1	1.4121
SIDM00889	CESC\|cervix	p.K435Q (No)	GDSC	I-BET-762	221.2172
SIDM00889	CESC\|cervix	p.K435Q (No)	GDSC	JQ1	0.85
SIDM00889	CESC\|cervix	p.K435Q (No)	GDSC	I-BET-762	214.41
SIDM00889	CESC\|cervix	p.K435Q (No)	GDSC	OTX015	122.61
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.K435Q (No)	GDSC	JQ1	0.9507
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.K435Q (No)	GDSC	I-BET-762	5.5114
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.K435Q (No)	GDSC	JQ1	0.3938
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.K435Q (No)	GDSC	I-BET-762	2.9656
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.K435Q (No)	GDSC	OTX015	0.6297
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	JQ1	0.8175
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	I-BET-762	27.3861
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	JQ1	7.2794
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	I-BET-762	5.2898
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	OTX015	0.925
SIDM00111	GBM\|glioma	p.K435Q (No)	GDSC	JQ1	1.1061
SIDM00111	GBM\|glioma	p.K435Q (No)	GDSC	I-BET-762	26.2956
SIDM00111	GBM\|glioma	p.K435Q (No)	GDSC	JQ1	1.7202
SIDM00111	GBM\|glioma	p.K435Q (No)	GDSC	I-BET-762	31.127
SIDM00111	GBM\|glioma	p.K435Q (No)	GDSC	OTX015	16.284
SIDM01074	GBM\|glioma	p.K435Q (No)	GDSC	JQ1	9.581
SIDM01074	GBM\|glioma	p.K435Q (No)	GDSC	I-BET-762	115.5562
SIDM01074	GBM\|glioma	p.K435Q (No)	GDSC	JQ1	8.515
SIDM01074	GBM\|glioma	p.K435Q (No)	GDSC	I-BET-762	4.1775
SIDM01074	GBM\|glioma	p.K435Q (No)	GDSC	OTX015	1.9351
SIDM00282	COREAD\|large_intestine	p.E564G (No)	GDSC	JQ1	75.1902
SIDM00282	COREAD\|large_intestine	p.E564G (No)	GDSC	I-BET-762	60.9888
SIDM00282	COREAD\|large_intestine	p.E564G (No)	GDSC	JQ1	25.4093
SIDM00282	COREAD\|large_intestine	p.E564G (No)	GDSC	I-BET-762	36.351
SIDM00282	COREAD\|large_intestine	p.E564G (No)	GDSC	OTX015	20.069
SIDM00282	COREAD\|large_intestine	p.W96* (No)	GDSC	JQ1	75.1902
SIDM00282	COREAD\|large_intestine	p.W96* (No)	GDSC	I-BET-762	60.9888
SIDM00282	COREAD\|large_intestine	p.W96* (No)	GDSC	JQ1	25.4093
SIDM00282	COREAD\|large_intestine	p.W96* (No)	GDSC	I-BET-762	36.351
SIDM00282	COREAD\|large_intestine	p.W96* (No)	GDSC	OTX015	20.069
SIDM01088	UNCLASSIFIED\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	1.3207
SIDM01088	UNCLASSIFIED\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	48.995
SIDM01088	UNCLASSIFIED\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	11.2727
SIDM01088	UNCLASSIFIED\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	18.636
SIDM01088	UNCLASSIFIED\|endometrium	p.P24fs*24 (No)	GDSC	OTX015	7.414
SIDM00469	PAAD\|pancreas	p.P23A (No)	GDSC	JQ1	19.0116
SIDM00469	PAAD\|pancreas	p.P23A (No)	GDSC	I-BET-762	9.8986
SIDM00469	PAAD\|pancreas	p.P23A (No)	GDSC	JQ1	6.9964
SIDM00469	PAAD\|pancreas	p.P23A (No)	GDSC	I-BET-762	185.08
SIDM00469	PAAD\|pancreas	p.P23A (No)	GDSC	OTX015	136.47
SIDM00321	UNCLASSIFIED\|ovary	p.S715F (No)	GDSC	JQ1	2.169
SIDM00321	UNCLASSIFIED\|ovary	p.S715F (No)	GDSC	I-BET-762	20.4407
SIDM00321	UNCLASSIFIED\|ovary	p.S715F (No)	GDSC	JQ1	6.5843
SIDM00321	UNCLASSIFIED\|ovary	p.S715F (No)	GDSC	I-BET-762	24.87
SIDM00321	UNCLASSIFIED\|ovary	p.S715F (No)	GDSC	OTX015	28.588
SIDM00886	DLBC\|B_cell_lymphoma	p.K435Q (No)	GDSC	JQ1	1.279
SIDM00886	DLBC\|B_cell_lymphoma	p.K435Q (No)	GDSC	I-BET-762	1.1173
SIDM00886	DLBC\|B_cell_lymphoma	p.K435Q (No)	GDSC	JQ1	0.5812
SIDM00886	DLBC\|B_cell_lymphoma	p.K435Q (No)	GDSC	I-BET-762	3.9598
SIDM00886	DLBC\|B_cell_lymphoma	p.K435Q (No)	GDSC	OTX015	5.2314
SIDM00660	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	OTX015	7.248
SIDM00660	COREAD\|large_intestine	p.E25fs*24 (No)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.E25fs*24 (No)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.E25fs*24 (No)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.E25fs*24 (No)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.E25fs*24 (No)	GDSC	OTX015	7.248
SIDM00238	OV\|ovary	p.P24fs*24 (No)	GDSC	I-BET-762	314.0424
SIDM00238	OV\|ovary	p.P24fs*24 (No)	GDSC	JQ1	14.1477
SIDM00238	OV\|ovary	p.P24fs*24 (No)	GDSC	I-BET-762	218.79
SIDM00238	OV\|ovary	p.P24fs*24 (No)	GDSC	OTX015	100.87
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P24fs*24 (No)	GDSC	JQ1	0.2912
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P24fs*24 (No)	GDSC	I-BET-762	211.2221
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P24fs*24 (No)	GDSC	JQ1	6.0328
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P24fs*24 (No)	GDSC	I-BET-762	51.997
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P24fs*24 (No)	GDSC	OTX015	11.089
SIDM00715	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	JQ1	0.7918
SIDM00715	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	I-BET-762	71.8478
SIDM00715	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	JQ1	3.1436
SIDM00954	BRCA\|breast	p.A172V (No)	GDSC	JQ1	2.622
SIDM00954	BRCA\|breast	p.A172V (No)	GDSC	I-BET-762	44.2865
SIDM00954	BRCA\|breast	p.A172V (No)	GDSC	JQ1	19.1166
SIDM00954	BRCA\|breast	p.A172V (No)	GDSC	I-BET-762	14.161
SIDM00954	BRCA\|breast	p.A172V (No)	GDSC	OTX015	30.337
SIDM00954	BRCA\|breast	p.A172V (No)	GDSC	JQ1	8.3058
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	JQ1	27.4948
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	I-BET-762	56.9189
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	JQ1	5.0151
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	I-BET-762	25.97
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	OTX015	13.61
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	JQ1	0.5636
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	I-BET-762	4.7421
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	JQ1	4.2649
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	I-BET-762	7.2251
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	OTX015	2.5363
SIDM00101	MESO\|mesothelioma	p.W96* (No)	GDSC	JQ1	1.5094
SIDM00101	MESO\|mesothelioma	p.W96* (No)	GDSC	I-BET-762	73.3381
SIDM00101	MESO\|mesothelioma	p.W96* (No)	GDSC	JQ1	22.6985
SIDM00101	MESO\|mesothelioma	p.W96* (No)	GDSC	I-BET-762	158.54
SIDM00101	MESO\|mesothelioma	p.W96* (No)	GDSC	OTX015	231.55
SIDM00257	NB\|neuroblastoma	p.A56S (No)	GDSC	JQ1	1.6252
SIDM00257	NB\|neuroblastoma	p.A56S (No)	GDSC	I-BET-762	8.8534
SIDM00257	NB\|neuroblastoma	p.A56S (No)	GDSC	JQ1	8.733
SIDM00257	NB\|neuroblastoma	p.A56S (No)	GDSC	I-BET-762	13.906
SIDM00257	NB\|neuroblastoma	p.A56S (No)	GDSC	OTX015	5.8639
SIDM00517	UNCLASSIFIED\|head_and_neck	p.K435Q (No)	GDSC	JQ1	0.2808
SIDM00517	UNCLASSIFIED\|head_and_neck	p.K435Q (No)	GDSC	I-BET-762	31.1718
SIDM00517	UNCLASSIFIED\|head_and_neck	p.K435Q (No)	GDSC	JQ1	8.2887
SIDM00517	UNCLASSIFIED\|head_and_neck	p.K435Q (No)	GDSC	I-BET-762	28.707
SIDM00517	UNCLASSIFIED\|head_and_neck	p.K435Q (No)	GDSC	OTX015	11.146
SIDM00789	COREAD\|large_intestine	p.P299S (No)	GDSC	JQ1	0.3654
SIDM00789	COREAD\|large_intestine	p.P299S (No)	GDSC	I-BET-762	76.3613
SIDM00789	COREAD\|large_intestine	p.P299S (No)	GDSC	JQ1	14.2422
SIDM00789	COREAD\|large_intestine	p.P299S (No)	GDSC	I-BET-762	8.0329
SIDM00789	COREAD\|large_intestine	p.P299S (No)	GDSC	OTX015	1.163
SIDM00534	COREAD\|large_intestine	p.A172V (No)	GDSC	JQ1	2.062
SIDM00534	COREAD\|large_intestine	p.A172V (No)	GDSC	I-BET-762	76.4984
SIDM00534	COREAD\|large_intestine	p.A172V (No)	GDSC	JQ1	12.3123
SIDM00534	COREAD\|large_intestine	p.A172V (No)	GDSC	I-BET-762	42.213
SIDM00534	COREAD\|large_intestine	p.A172V (No)	GDSC	OTX015	33.596
SIDM00534	COREAD\|large_intestine	p.N37K (No)	GDSC	JQ1	2.062
SIDM00534	COREAD\|large_intestine	p.N37K (No)	GDSC	I-BET-762	76.4984
SIDM00534	COREAD\|large_intestine	p.N37K (No)	GDSC	JQ1	12.3123
SIDM00534	COREAD\|large_intestine	p.N37K (No)	GDSC	I-BET-762	42.213
SIDM00534	COREAD\|large_intestine	p.N37K (No)	GDSC	OTX015	33.596
SIDM00534	COREAD\|large_intestine	p.V26G (No)	GDSC	JQ1	2.062
SIDM00534	COREAD\|large_intestine	p.V26G (No)	GDSC	I-BET-762	76.4984
SIDM00534	COREAD\|large_intestine	p.V26G (No)	GDSC	JQ1	12.3123
SIDM00534	COREAD\|large_intestine	p.V26G (No)	GDSC	I-BET-762	42.213
SIDM00534	COREAD\|large_intestine	p.V26G (No)	GDSC	OTX015	33.596
SIDM00680	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	0.4512
SIDM00680	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	79.6804
SIDM00680	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	32.6888
SIDM00680	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	160.11
SIDM00680	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	OTX015	32.631
SIDM00336	SKCM\|melanoma	p.K435Q (No)	GDSC	JQ1	1.4146
SIDM00336	SKCM\|melanoma	p.K435Q (No)	GDSC	I-BET-762	160.6765
SIDM00336	SKCM\|melanoma	p.K435Q (No)	GDSC	JQ1	11.6441
SIDM00336	SKCM\|melanoma	p.K435Q (No)	GDSC	I-BET-762	50.117
SIDM00336	SKCM\|melanoma	p.K435Q (No)	GDSC	OTX015	38.668
SIDM00487	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	0.3787
SIDM00487	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	3.8672
SIDM00487	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	5.544
SIDM00487	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	5.7033
SIDM00487	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	OTX015	3.2362
SIDM00487	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	0.3787
SIDM00487	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	3.8672
SIDM00487	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	5.544
SIDM00487	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	5.7033
SIDM00487	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	OTX015	3.2362
SIDM00282	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	75.1902
SIDM00282	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	60.9888
SIDM00282	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	25.4093
SIDM00282	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	36.351
SIDM00282	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	OTX015	20.069
SIDM01041	ESCA\|oesophagus	p.T250P (No)	GDSC	I-BET-762	187.3981
SIDM01041	ESCA\|oesophagus	p.T250P (No)	GDSC	JQ1	16.7627
SIDM01041	ESCA\|oesophagus	p.T250P (No)	GDSC	I-BET-762	19.518
SIDM01041	ESCA\|oesophagus	p.T250P (No)	GDSC	OTX015	4.1478
SIDM00136	COREAD\|large_intestine	p.P149A (No)	GDSC	JQ1	0.1772
SIDM00136	COREAD\|large_intestine	p.P149A (No)	GDSC	I-BET-762	25.8739
SIDM00136	COREAD\|large_intestine	p.P149A (No)	GDSC	JQ1	33.1636
SIDM00136	COREAD\|large_intestine	p.P149A (No)	GDSC	I-BET-762	3.5792
SIDM00136	COREAD\|large_intestine	p.P149A (No)	GDSC	OTX015	1.2126
SIDM01082	HNSC\|head_and_neck	p.K435Q (No)	GDSC	JQ1	0.7477
SIDM01082	HNSC\|head_and_neck	p.K435Q (No)	GDSC	I-BET-762	65.0716
SIDM01082	HNSC\|head_and_neck	p.K435Q (No)	GDSC	JQ1	4.4795
SIDM00217	COREAD\|large_intestine	p.I132fs*111 (No)	GDSC	I-BET-762	20.859
SIDM00217	COREAD\|large_intestine	p.I132fs*111 (No)	GDSC	JQ1	5.699
SIDM00217	COREAD\|large_intestine	p.I132fs*111 (No)	GDSC	I-BET-762	45.177
SIDM00217	COREAD\|large_intestine	p.I132fs*111 (No)	GDSC	OTX015	13.116
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.A172V (No)	GDSC	JQ1	0.3557
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.A172V (No)	GDSC	I-BET-762	2.6358
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.A172V (No)	GDSC	JQ1	0.3064
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.A172V (No)	GDSC	I-BET-762	3.7152
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.A172V (No)	GDSC	OTX015	1.2985
SIDM00628	BRCA\|breast	p.A172V (No)	GDSC	JQ1	0.5633
SIDM00628	BRCA\|breast	p.A172V (No)	GDSC	I-BET-762	69.2874
SIDM00628	BRCA\|breast	p.A172V (No)	GDSC	JQ1	8.5171
SIDM00628	BRCA\|breast	p.A172V (No)	GDSC	I-BET-762	51.757
SIDM00628	BRCA\|breast	p.A172V (No)	GDSC	OTX015	9.2643
SIDM00628	BRCA\|breast	p.A172V (No)	GDSC	JQ1	37.01
SIDM00545	SKCM\|melanoma	p.P355L (No)	GDSC	JQ1	19.0047
SIDM00545	SKCM\|melanoma	p.P355L (No)	GDSC	I-BET-762	237.53
SIDM00545	SKCM\|melanoma	p.P355L (No)	GDSC	JQ1	16.7562
SIDM00545	SKCM\|melanoma	p.P355S (No)	GDSC	JQ1	19.0047
SIDM00545	SKCM\|melanoma	p.P355S (No)	GDSC	I-BET-762	237.53
SIDM00545	SKCM\|melanoma	p.P355S (No)	GDSC	JQ1	16.7562
SIDM00120	PRAD\|prostate	p.A10T (No)	GDSC	JQ1	0.7323
SIDM00120	PRAD\|prostate	p.A10T (No)	GDSC	I-BET-762	286.8657
SIDM00120	PRAD\|prostate	p.A10T (No)	GDSC	JQ1	4.1512
SIDM00120	PRAD\|prostate	p.A10T (No)	GDSC	I-BET-762	298.43
SIDM00120	PRAD\|prostate	p.A10T (No)	GDSC	OTX015	55.349
SIDM00114	MESO\|mesothelioma	p.R631K (No)	GDSC	JQ1	24.6189
SIDM00114	MESO\|mesothelioma	p.R631K (No)	GDSC	I-BET-762	263.6372
SIDM00114	MESO\|mesothelioma	p.R631K (No)	GDSC	JQ1	12.8474
SIDM00114	MESO\|mesothelioma	p.R631K (No)	GDSC	I-BET-762	105.86
SIDM00114	MESO\|mesothelioma	p.R631K (No)	GDSC	OTX015	77.226
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.V174M (No)	GDSC	JQ1	0.9524
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.V174M (No)	GDSC	I-BET-762	52.969
SIDM00541	COREAD\|large_intestine	p.E144V (No)	GDSC	JQ1	9.5591
SIDM00541	COREAD\|large_intestine	p.E144V (No)	GDSC	I-BET-762	260.247
SIDM00541	COREAD\|large_intestine	p.E144V (No)	GDSC	JQ1	16.3669
SIDM00541	COREAD\|large_intestine	p.E144V (No)	GDSC	I-BET-762	5.9033
SIDM00541	COREAD\|large_intestine	p.E144V (No)	GDSC	OTX015	2.4086
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.P23H (No)	GDSC	JQ1	0.5954
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.P23H (No)	GDSC	I-BET-762	3.5792
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.P23H (No)	GDSC	JQ1	10.7262
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.P23H (No)	GDSC	I-BET-762	11.765
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.P23H (No)	GDSC	OTX015	2.6699
SIDM01173	UNCLASSIFIED\|rhabdomyosarcoma	p.V174M (No)	GDSC	JQ1	4.9806
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A138V (No)	GDSC	JQ1	0.2855
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A138V (No)	GDSC	I-BET-762	1.5369
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A138V (No)	GDSC	JQ1	8.8691
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A138V (No)	GDSC	I-BET-762	7.1915
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A138V (No)	GDSC	OTX015	2.3039
SIDM00364	ALL\|lymphoblastic_leukemia	p.T250P (No)	GDSC	JQ1	0.1659
SIDM00364	ALL\|lymphoblastic_leukemia	p.T250P (No)	GDSC	I-BET-762	0.6404
SIDM00364	ALL\|lymphoblastic_leukemia	p.T250P (No)	GDSC	JQ1	0.1489
SIDM00364	ALL\|lymphoblastic_leukemia	p.T250P (No)	GDSC	I-BET-762	3.2944
SIDM00364	ALL\|lymphoblastic_leukemia	p.T250P (No)	GDSC	OTX015	0.7053
SIDM00080	SKCM\|melanoma	p.Q662* (No)	GDSC	JQ1	2.4537
SIDM00080	SKCM\|melanoma	p.Q662* (No)	GDSC	I-BET-762	86.2642
SIDM00080	SKCM\|melanoma	p.Q662* (No)	GDSC	JQ1	15.1263
SIDM00080	SKCM\|melanoma	p.Q662* (No)	GDSC	I-BET-762	107.62
SIDM00080	SKCM\|melanoma	p.Q662* (No)	GDSC	OTX015	41.066
SIDM00465	OV\|ovary	p.E689* (No)	GDSC	JQ1	0.3574
SIDM00465	OV\|ovary	p.E689* (No)	GDSC	I-BET-762	9.9296
SIDM00465	OV\|ovary	p.E689* (No)	GDSC	I-BET-762	29.802
SIDM00465	OV\|ovary	p.E689* (No)	GDSC	OTX015	15.549
SIDM00285	NB\|neuroblastoma	p.K435Q (No)	GDSC	I-BET-762	4.2039
SIDM00285	NB\|neuroblastoma	p.K435Q (No)	GDSC	I-BET-762	15.805
SIDM00285	NB\|neuroblastoma	p.K435Q (No)	GDSC	OTX015	16.891
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.K591R (No)	GDSC	JQ1	6.9238
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.K591R (No)	GDSC	I-BET-762	46.4669
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.K591R (No)	GDSC	JQ1	7.7194
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.K591R (No)	GDSC	I-BET-762	227.3
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.K591R (No)	GDSC	OTX015	203.5
SIDM01169	OV\|ovary	p.P24fs*24 (No)	GDSC	JQ1	3.5773
SIDM01169	OV\|ovary	p.P24fs*24 (No)	GDSC	I-BET-762	174.9391
SIDM01169	OV\|ovary	p.P24fs*24 (No)	GDSC	JQ1	13.1046
SIDM01169	OV\|ovary	p.P24fs*24 (No)	GDSC	I-BET-762	37.853
SIDM01169	OV\|ovary	p.P24fs*24 (No)	GDSC	OTX015	4.4771
SIDM01169	OV\|ovary	p.E25fs*51 (No)	GDSC	JQ1	3.5773
SIDM01169	OV\|ovary	p.E25fs*51 (No)	GDSC	I-BET-762	174.9391
SIDM01169	OV\|ovary	p.E25fs*51 (No)	GDSC	JQ1	13.1046
SIDM01169	OV\|ovary	p.E25fs*51 (No)	GDSC	I-BET-762	37.853
SIDM01169	OV\|ovary	p.E25fs*51 (No)	GDSC	OTX015	4.4771
SIDM00892	BRCA\|breast	p.P188A (No)	GDSC	JQ1	4.4809
SIDM00892	BRCA\|breast	p.P188A (No)	GDSC	I-BET-762	61.1974
SIDM00892	BRCA\|breast	p.P188A (No)	GDSC	JQ1	34.4732
SIDM00892	BRCA\|breast	p.P188A (No)	GDSC	JQ1	20.534
SIDM01246	NB\|neuroblastoma	p.K435Q (No)	GDSC	JQ1	0.3787
SIDM01246	NB\|neuroblastoma	p.K435Q (No)	GDSC	I-BET-762	58.6481
SIDM01246	NB\|neuroblastoma	p.K435Q (No)	GDSC	JQ1	4.1927
SIDM00875	UNCLASSIFIED\|breast	p.V174M (No)	GDSC	JQ1	2.7845
SIDM00875	UNCLASSIFIED\|breast	p.V174M (No)	GDSC	I-BET-762	71.8758
SIDM00875	UNCLASSIFIED\|breast	p.V174M (No)	GDSC	JQ1	8.9974
SIDM00875	UNCLASSIFIED\|breast	p.V174M (No)	GDSC	I-BET-762	17.667
SIDM00875	UNCLASSIFIED\|breast	p.V174M (No)	GDSC	OTX015	9.1906
SIDM00875	UNCLASSIFIED\|breast	p.V174M (No)	GDSC	JQ1	4.1871
SIDM00333	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	JQ1	0.4262
SIDM00333	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	I-BET-762	195.2428
SIDM00333	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	JQ1	10.3097
SIDM00333	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	I-BET-762	39.801
SIDM00333	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	OTX015	22.454
SIDM00118	COREAD\|large_intestine	p.N92K (No)	GDSC	JQ1	0.9581
SIDM00118	COREAD\|large_intestine	p.N92K (No)	GDSC	I-BET-762	95.874
SIDM00118	COREAD\|large_intestine	p.N92K (No)	GDSC	JQ1	9.4882
SIDM00118	COREAD\|large_intestine	p.N92K (No)	GDSC	I-BET-762	11.965
SIDM00118	COREAD\|large_intestine	p.N92K (No)	GDSC	OTX015	3.7042
SIDM00596	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	0.641
SIDM00596	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	201.9926
SIDM00596	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	9.0853
SIDM00596	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	19.258
SIDM00596	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	OTX015	5.1627

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSSDS

Degron related mutations and impact score

Drug responses associated with BRD3 mutations

All proteins holding degron of DSGSSDS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15059	Bromodomain-containing protein 3	DEG_SCF_TRCP1_1	449:455	DSGSSDS	BTRC	0.9481	More...