DegronMD - P39060(COL18A1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R67G	TCGA-06-1802	GBM	TCGA	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.R67G	TCGA-GL-A59R	KIRP	TCGA	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.R67G	DO12100	GBM	ICGC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.R67G	DO44525	KIRP	ICGC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.T65I	TCGA-EB-A3Y6	SKCM	TCGA	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.25
p.T65I	DO38081	SKCM	ICGC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.25
p.R67W	TCGA-G4-6297	COAD	TCGA	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.R67W	DO9418	COAD	ICGC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.P48A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.P48A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.P48A	SIDM00454	Rhabdomyosarcoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.P48A	SIDM00846	Cervical Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.P48A	SIDM00971	Breast Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.P48A	SIDM00254	Neuroblastoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.P48A	SIDM00808	Burkitt's Lymphoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.P48A	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.P48A	SIDM01254	Burkitt's Lymphoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.P48A	SIDM01525	Acute Myeloid Leukemia	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.Q49L	SIDM00969	Ovarian Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.Q49L	SIDM00656	Burkitt's Lymphoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.Q49L	SIDM00879	Breast Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.Q49L	SIDM00309	Mesothelioma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.Q49L	SIDM00641	Burkitt's Lymphoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.Q49L	SIDM01664	Prostate Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.Q49L	SIDM01387	Small Cell Lung Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.T59M	SNU-175	large intestine	COSMIC	ADTTT	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7423

Kaplan plot for COL18A1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL18A1

UniProt ID: P39060

Entrez ID: 80781

Protein name: Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for COL18A1 in