DegronMD

Uniprot ID: Q58F21

Source protein: Bromodomain testis-specific protein

Source gene: BRDT

Class: DEG_SPOP_SBC_1

Location: 215:219

E3 ligase: SPOP

DEGRON score: 0.9952

ASA_SCORE: 80.1

COIL: 0.873

CONS_SCORE: 0.4566

DSS_SCORE: 0.4836

HELIX: 0.0586

FCONS_SCORE: 1.1169

RIG_SCORE: 0.7124

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A215V	TCGA-DF-A2KU	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	0.5825
p.A215V	DO223286	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	0.5825
p.K212N	TCGA-EE-A183	SKCM	TCGA	ADTTT	DEG_SPOP_SBC_1	0.3611
p.K212N	DO37715	SKCM	ICGC	ADTTT	DEG_SPOP_SBC_1	0.3611
p.T208A	TCGA-EO-A22X	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	0.1389
p.T208A	DO43907	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1389
p.A215E	TCGA-MK-A84Z	THCA	TCGA	ADTTT	DEG_SPOP_SBC_1	0.7701
p.A215E	DO51460	THCA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.7701
p.A221V	DO233115	GACA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.2778
p.S229I	DO229022	LICA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.A205V	ACH-001369	Ovarian Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	0.0556
p.H215Y	NCI-H1770	lung	COSMIC	ADTTT	DEG_SPOP_SBC_1	0.7229
p.K213N	HCC2998	large_intestine	COSMIC	ADTTT	DEG_SPOP_SBC_1	0.2778
p.V226L	NCI-H2110	lung	COSMIC	ADTTT	DEG_SPOP_SBC_1	0.25
p.V217I	SF295	central_nervous_system	COSMIC	ADTTT	DEG_SPOP_SBC_1	0.7076
p.E209Q	NCI-H187	lung	COSMIC	ADTTT	DEG_SPOP_SBC_1	0.2778

Drug responses associated with BRDT mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R700I (No)	GDSC	JQ1	0.8175
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R700I (No)	GDSC	JQ1	7.2794
SIDM00420	BLCA\|bladder	p.S196L (No)	GDSC	JQ1	0.0632
SIDM00420	BLCA\|bladder	p.S196L (No)	GDSC	JQ1	9.968
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I393T (No)	GDSC	JQ1	0.7368
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.I393T (No)	GDSC	JQ1	6.9137
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R82H (No)	GDSC	JQ1	0.1093
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R82H (No)	GDSC	JQ1	6.0862
SIDM00260	STAD\|stomach	p.Q10* (No)	GDSC	JQ1	1.2987
SIDM01051	UNCLASSIFIED\|ovary	p.G527R (No)	GDSC	JQ1	0.4035
SIDM01051	UNCLASSIFIED\|ovary	p.G527R (No)	GDSC	JQ1	13.1406
SIDM00320	LUAD\|lung_NSCLC_adenocarcinoma	p.G699* (No)	GDSC	JQ1	7.2879
SIDM00292	SCLC\|lung_small_cell_carcinoma	p.R6Q (No)	GDSC	JQ1	12.8014
SIDM00292	SCLC\|lung_small_cell_carcinoma	p.R6Q (No)	GDSC	JQ1	4.5854
SIDM01106	SKCM\|melanoma	p.M690I (No)	GDSC	JQ1	0.1859
SIDM01106	SKCM\|melanoma	p.M690I (No)	GDSC	JQ1	17.7711
SIDM00982	GBM\|glioma	p.K839E (No)	GDSC	JQ1	1.905
SIDM00982	GBM\|glioma	p.K839E (No)	GDSC	JQ1	7.9292
SIDM00194	COREAD\|large_intestine	p.E685G (No)	GDSC	JQ1	10.9153
SIDM00044	HNSC\|head_and_neck	p.S5I (No)	GDSC	JQ1	43.1291
SIDM00044	HNSC\|head_and_neck	p.S5I (No)	GDSC	JQ1	19.9746
SIDM00504	LGG\|glioma	p.Q517R (No)	GDSC	JQ1	0.4454
SIDM00504	LGG\|glioma	p.Q517R (No)	GDSC	JQ1	8.3802
SIDM00716	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P444H (No)	GDSC	JQ1	3.5405
SIDM00716	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P444H (No)	GDSC	JQ1	6.055
SIDM00791	LCML\|chronic_myeloid_leukaemia	p.R532* (No)	GDSC	JQ1	29.1051
SIDM00791	LCML\|chronic_myeloid_leukaemia	p.R532* (No)	GDSC	JQ1	11.1824
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.E282Q (No)	GDSC	JQ1	7.5775
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.E282Q (No)	GDSC	JQ1	14.1677
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.K463M (No)	GDSC	JQ1	1.7184
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.K463M (No)	GDSC	JQ1	0.701
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V813L (No)	GDSC	JQ1	1.8009
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V813L (No)	GDSC	JQ1	14.685
SIDM00084	GBM\|glioma	p.V263I (No)	GDSC	JQ1	0.4729
SIDM00084	GBM\|glioma	p.V263I (No)	GDSC	JQ1	6.8956
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.S762L (No)	GDSC	JQ1	1.0227
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.S762L (No)	GDSC	JQ1	2.5702
SIDM01042	BRCA\|breast	p.D114G (No)	GDSC	JQ1	0.6062
SIDM01042	BRCA\|breast	p.D114G (No)	GDSC	JQ1	8.8946
SIDM01042	BRCA\|breast	p.D114G (No)	GDSC	JQ1	0.3458
SIDM00150	COREAD\|large_intestine	p.L437F (No)	GDSC	JQ1	0.6889
SIDM00150	COREAD\|large_intestine	p.L437F (No)	GDSC	JQ1	14.8593
SIDM00349	ESCA\|oesophagus	p.S407C (No)	GDSC	JQ1	0.3163
SIDM00349	ESCA\|oesophagus	p.S407C (No)	GDSC	JQ1	10.6034
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.M384I (No)	GDSC	JQ1	3.7899
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V299L (No)	GDSC	JQ1	1.5057
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V299L (No)	GDSC	JQ1	6.9135
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A405T (No)	GDSC	JQ1	7.4871
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A405T (No)	GDSC	JQ1	6.2721
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.P353H (No)	GDSC	JQ1	20.379
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.P353H (No)	GDSC	JQ1	24.6818
SIDM00737	UNCLASSIFIED\|lung_NSCLC_not_specified	p.H288Y (No)	GDSC	JQ1	0.8579
SIDM00737	UNCLASSIFIED\|lung_NSCLC_not_specified	p.H288Y (No)	GDSC	JQ1	12.0268
SIDM00990	UNCLASSIFIED\|lung_NSCLC_not_specified	p.S769* (No)	GDSC	JQ1	0.1543
SIDM00990	UNCLASSIFIED\|lung_NSCLC_not_specified	p.S769* (No)	GDSC	JQ1	18.7859
SIDM00534	COREAD\|large_intestine	p.N470S (No)	GDSC	JQ1	2.062
SIDM00534	COREAD\|large_intestine	p.N470S (No)	GDSC	JQ1	12.3123
SIDM00555	GBM\|glioma	p.R6Q (No)	GDSC	JQ1	0.2248
SIDM00555	GBM\|glioma	p.R6Q (No)	GDSC	JQ1	9.3291
SIDM00963	BRCA\|breast	p.D414N (No)	GDSC	JQ1	2.135
SIDM00963	BRCA\|breast	p.D414N (No)	GDSC	JQ1	25.7491
SIDM00963	BRCA\|breast	p.D414N (No)	GDSC	JQ1	42.196
SIDM01015	LCML\|chronic_myeloid_leukaemia	p.E632D (No)	GDSC	JQ1	1.4915
SIDM01015	LCML\|chronic_myeloid_leukaemia	p.E632D (No)	GDSC	JQ1	3.7121
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.L365P (No)	GDSC	JQ1	4.9169
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.L365P (No)	GDSC	JQ1	8.8854
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.V381F (No)	GDSC	JQ1	0.3436
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.V381F (No)	GDSC	JQ1	13.1372
SIDM00114	MESO\|mesothelioma	p.Q488E (No)	GDSC	JQ1	24.6189
SIDM00114	MESO\|mesothelioma	p.Q488E (No)	GDSC	JQ1	12.8474
SIDM01080	HNSC\|head_and_neck	p.K751R (No)	GDSC	JQ1	0.1022
SIDM01080	HNSC\|head_and_neck	p.K751R (No)	GDSC	JQ1	2.07
SIDM00652	SCLC\|lung_small_cell_carcinoma	p.N190I (No)	GDSC	JQ1	10.3356
SIDM00383	UNCLASSIFIED\|stomach	p.K836N (No)	GDSC	JQ1	42.7437
SIDM00383	UNCLASSIFIED\|stomach	p.K836N (No)	GDSC	JQ1	14.9955
SIDM00537	COREAD\|large_intestine	p.R82H (No)	GDSC	JQ1	0.3119
SIDM00537	COREAD\|large_intestine	p.R82H (No)	GDSC	JQ1	8.9937
SIDM01146	STAD\|stomach	p.R6Q (No)	GDSC	JQ1	1.2842
SIDM01146	STAD\|stomach	p.R6Q (No)	GDSC	JQ1	11.5092
SIDM00333	UCEC\|endometrium	p.Q600fs*11 (No)	GDSC	JQ1	0.4262
SIDM00333	UCEC\|endometrium	p.Q600fs*11 (No)	GDSC	JQ1	10.3097
SIDM00193	COREAD\|large_intestine	p.S572L (No)	GDSC	JQ1	21.8249
SIDM00118	COREAD\|large_intestine	p.K286N (No)	GDSC	JQ1	0.9581
SIDM00118	COREAD\|large_intestine	p.K286N (No)	GDSC	JQ1	9.4882
SIDM00118	COREAD\|large_intestine	p.E566* (No)	GDSC	JQ1	0.9581
SIDM00118	COREAD\|large_intestine	p.E566* (No)	GDSC	JQ1	9.4882

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	129:133	ADTTT	SPOP	0.8638	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	292:296	ADTTT	SPOP	0.9991	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	283:287	ADTTT	SPOP	0.9945	More...
P39060	Collagen alpha-1	DEG_SPOP_SBC_1	58:62	ADTTT	SPOP	0.8165	More...
Q15059	Bromodomain-containing protein 3	DEG_SPOP_SBC_1	246:250	ADTTT	SPOP	0.9976	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	215:219	ADTTT	SPOP	0.9952	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	38:42	ADTTT	SPOP	0.9983	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	667:671	ADTTT	SPOP	0.9939	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	251:255	ADTTT	SPOP	0.9047	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADTTT

Degron related mutations and impact score

Drug responses associated with BRDT mutations

All proteins holding degron of ADTTT