DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ADTTT
Uniprot ID:
Q58F21
Source protein:
Bromodomain testis-specific protein
Source gene:
BRDT
Class:
DEG_SPOP_SBC_1
Location:
215:219
E3 ligase:
SPOP
DEGRON score:
0.9952
ASA_SCORE:
80.1
COIL:
0.873
CONS_SCORE:
0.4566
DSS_SCORE:
0.4836
HELIX:
0.0586
FCONS_SCORE:
1.1169
RIG_SCORE:
0.7124
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A215E
TCGA-MK-A84Z
THCA
TCGA
ADTTT
DEG_SPOP_SBC_1
0.7701
p.A215E
DO51460
THCA
ICGC
ADTTT
DEG_SPOP_SBC_1
0.7701
p.H215Y
NCI-H1770
lung
COSMIC
ADTTT
DEG_SPOP_SBC_1
0.7229
p.V217I
SF295
central_nervous_system
COSMIC
ADTTT
DEG_SPOP_SBC_1
0.7076
p.A215V
TCGA-DF-A2KU
UCEC
TCGA
ADTTT
DEG_SPOP_SBC_1
0.5825
p.A215V
DO223286
UCEC
ICGC
ADTTT
DEG_SPOP_SBC_1
0.5825
p.K212N
TCGA-EE-A183
SKCM
TCGA
ADTTT
DEG_SPOP_SBC_1
0.3611
p.K212N
DO37715
SKCM
ICGC
ADTTT
DEG_SPOP_SBC_1
0.3611
p.A221V
DO233115
GACA
ICGC
ADTTT
DEG_SPOP_SBC_1
0.2778
p.K213N
HCC2998
large_intestine
COSMIC
ADTTT
DEG_SPOP_SBC_1
0.2778
p.E209Q
NCI-H187
lung
COSMIC
ADTTT
DEG_SPOP_SBC_1
0.2778
p.V226L
NCI-H2110
lung
COSMIC
ADTTT
DEG_SPOP_SBC_1
0.25
p.T208A
TCGA-EO-A22X
UCEC
TCGA
ADTTT
DEG_SPOP_SBC_1
0.1389
p.T208A
DO43907
UCEC
ICGC
ADTTT
DEG_SPOP_SBC_1
0.1389
p.S229I
DO229022
LICA
ICGC
ADTTT
DEG_SPOP_SBC_1
0.0556
p.A205V
ACH-001369
Ovarian Cancer
CCLE
ADTTT
DEG_SPOP_SBC_1
0.0556
Showing 1 to 16 of 16 entries
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Drug responses associated with BRDT mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
SIDM00463
ALL|lymphoblastic_T_cell_leukaemia
p.I393T (No)
GDSC
JQ1
0.7368
SIDM00463
ALL|lymphoblastic_T_cell_leukaemia
p.I393T (No)
GDSC
JQ1
6.9137
SIDM00403
ALL|lymphoblastic_T_cell_leukaemia
p.S762L (No)
GDSC
JQ1
1.0227
SIDM00403
ALL|lymphoblastic_T_cell_leukaemia
p.S762L (No)
GDSC
JQ1
2.5702
SIDM00420
BLCA|bladder
p.S196L (No)
GDSC
JQ1
0.0632
SIDM00420
BLCA|bladder
p.S196L (No)
GDSC
JQ1
9.968
SIDM01042
BRCA|breast
p.D114G (No)
GDSC
JQ1
0.6062
SIDM01042
BRCA|breast
p.D114G (No)
GDSC
JQ1
8.8946
SIDM01042
BRCA|breast
p.D114G (No)
GDSC
JQ1
0.3458
SIDM00963
BRCA|breast
p.D414N (No)
GDSC
JQ1
2.135
SIDM00963
BRCA|breast
p.D414N (No)
GDSC
JQ1
25.7491
SIDM00963
BRCA|breast
p.D414N (No)
GDSC
JQ1
42.196
SIDM00194
COREAD|large_intestine
p.E685G (No)
GDSC
JQ1
10.9153
SIDM00150
COREAD|large_intestine
p.L437F (No)
GDSC
JQ1
0.6889
SIDM00150
COREAD|large_intestine
p.L437F (No)
GDSC
JQ1
14.8593
SIDM00534
COREAD|large_intestine
p.N470S (No)
GDSC
JQ1
2.062
SIDM00534
COREAD|large_intestine
p.N470S (No)
GDSC
JQ1
12.3123
SIDM00537
COREAD|large_intestine
p.R82H (No)
GDSC
JQ1
0.3119
SIDM00537
COREAD|large_intestine
p.R82H (No)
GDSC
JQ1
8.9937
SIDM00193
COREAD|large_intestine
p.S572L (No)
GDSC
JQ1
21.8249
SIDM00118
COREAD|large_intestine
p.K286N (No)
GDSC
JQ1
0.9581
SIDM00118
COREAD|large_intestine
p.K286N (No)
GDSC
JQ1
9.4882
SIDM00118
COREAD|large_intestine
p.E566* (No)
GDSC
JQ1
0.9581
SIDM00118
COREAD|large_intestine
p.E566* (No)
GDSC
JQ1
9.4882
SIDM00349
ESCA|oesophagus
p.S407C (No)
GDSC
JQ1
0.3163
Showing 1 to 25 of 86 entries
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All proteins holding degron of ADTTT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q58F21
Bromodomain testis-specific protein
DEG_SPOP_SBC_1
215:219
ADTTT
SPOP
0.9952
More...
P25440
Bromodomain-containing protein 2
DEG_SPOP_SBC_1
283:287
ADTTT
SPOP
0.9945
More...
Q15059
Bromodomain-containing protein 3
DEG_SPOP_SBC_1
246:250
ADTTT
SPOP
0.9976
More...
O60885
Bromodomain-containing protein 4
DEG_SPOP_SBC_1
292:296
ADTTT
SPOP
0.9991
More...
P39060
Collagen alpha-1
DEG_SPOP_SBC_1
58:62
ADTTT
SPOP
0.8165
More...
Q9H9B1
Histone-lysine N-methyltransferase EHMT1
DEG_SPOP_SBC_1
667:671
ADTTT
SPOP
0.9939
More...
Q6ZVD8
PH domain leucine-rich repeat-containing protein phosphatase 2
DEG_SPOP_SBC_1
38:42
ADTTT
SPOP
0.9983
More...
O00592
Podocalyxin
DEG_SPOP_SBC_1
129:133
ADTTT
SPOP
0.8638
More...
Q8N9M1
Uncharacterized protein C19orf47
DEG_SPOP_SBC_1
251:255
ADTTT
SPOP
0.9047
More...
Showing 1 to 9 of 9 entries
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