DegronMD - P25440(BRD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E770G	TCGA-13-1477	OV	TCGA	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.1667
p.E770G	DO27978	OV	ICGC	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.1667
p.G278V	TCGA-14-1034	GBM	TCGA	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1944
p.G278V	DO11148	GBM	ICGC	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1944
p.V218F	TCGA-43-2581	LUSC	TCGA	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.1111
p.V218F	DO26602	LUSC	ICGC	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.1111
p.S482G	TCGA-AA-3821	COAD	TCGA	AKSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.S482G	DO9314	COAD	ICGC	AKSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.H223Y	TCGA-AG-4009	READ	TCGA	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.25
p.H223Y	DO36961	READ	ICGC	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.25
p.K773N	TCGA-AJ-A3BH	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.25
p.K773N	DO41638	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.25
p.A274T	TCGA-AP-A1DK	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.0833
p.A274T	DO42033	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.0833
p.R401W	TCGA-BG-A222	UCEC	TCGA	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1667
p.R401W	DO42977	UCEC	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1667
p.R774Q	TCGA-BR-4362	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.2778
p.R774Q	DO38336	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.2778
p.H242R	TCGA-CG-5721	STAD	TCGA	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.0556
p.S466F	TCGA-CU-A72E	BLCA	TCGA	AKSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1111
p.S466F	DO49734	BLCA	ICGC	AKSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1111
p.S486I	TCGA-DX-A6YV	SARC	TCGA	AKSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1111
p.S486I	DO220011	SARC	ICGC	AKSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1111
p.N783S	TCGA-E9-A3QA	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.25
p.N783S	TCGA-XF-A8HG	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.25
p.N783S	DO49802	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.25
p.N783S	DO44268	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.25
p.N783S	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.25
p.N783S	ACH-000914	Lymphoma	CCLE	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.25
p.N783S	HT	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.25
p.P241L	TCGA-EE-A29E	SKCM	TCGA	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.0833
p.L294M	TCGA-FI-A2D5	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1389
p.L294M	DO41331	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1389
p.S476L	TCGA-HU-A4GX	STAD	TCGA	AKSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7667
p.S476L	DO47757	STAD	ICGC	AKSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7667
p.E232Q	TCGA-LT-A5Z6	BLCA	TCGA	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation altering degron motif	0.6744
p.E232Q	DO44029	BLCA	ICGC	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation altering degron motif	0.6744
p.L273P	TCGA-QS-A5YR	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.0556
p.L273P	DO50081	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.0556
p.K400R	TCGA-TM-A84R	LGG	TCGA	DYR	CBL_MET	407:409	Mutation blocking ubiquitination signal	0.5833
p.P789L	TCGA-WE-A8ZX	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation blocking phosphorylation signal	0.5278
p.P789L	DO51291	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation blocking phosphorylation signal	0.5278
p.E404D	TCGA-XF-A9ST	BLCA	TCGA	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.25
p.E404D	DO223599	BLCA	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.25
p.S397R	DO874	BOCA	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.0556
p.K402E	DO222798	COCA	ICGC	DYR	CBL_MET	407:409	Mutation substituting flanking lysine	0.3056
p.L774F	DO233902	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.2778
p.T785S	DO233909	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation blocking phosphorylation signal	0.6389
p.K280R	DO50241	LGG	ICGC	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation substituting flanking lysine	0.3611
p.P216A	DO228416	LICA	ICGC	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.0556
p.P230L	DO50805	LIRI	ICGC	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation altering degron motif	0.6471
p.K400M	DO52682	MALY	ICGC	DYR	CBL_MET	407:409	Mutation blocking ubiquitination signal	0.5833
p.E770K	DO52686	MALY	ICGC	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.1667
p.P288S	DO229494	SKCA	ICGC	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.3056
p.A292T	SIDM00781	Colorectal Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1944
p.A292T	SIDM00780	Colorectal Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1944
p.A292T	ACH-000967	Colon/Colorectal Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1944
p.A292T	ACH-001199	Colon/Colorectal Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1944
p.A292T	SNU-C2B	large intestine	COSMIC	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1944
p.P216S	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.0556
p.P216S	ACH-000875	Lung Cancer	CCLE	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.0556
p.P216S	NCI-H2347	lung	COSMIC	LYTPPPE	DEG_SCF_FBW7_2	226:232	Mutation rewiring degron network	0.0556
p.R769Q	ACH-002061	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	776:780	Mutation rewiring degron network	0.1389
p.P276S	HUH-6-clone5	liver	COSMIC	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation substituting flanking lysine	0.25
p.E475G	SNU-175	large intestine	COSMIC	AKSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7199
p.D286Y	MFM-223	breast	COSMIC	ADTTT	DEG_SPOP_SBC_1	283:287	Mutation altering degron motif	0.7325

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRD2

UniProt ID: P25440

Entrez ID: 6046

Protein name: Bromodomain-containing protein 2 (O27.1.1) (Really interesting new gene 3 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRD2 in