DegronMD

Uniprot ID: P25440

Source protein: Bromodomain-containing protein 2

Source gene: BRD2

Class: DEG_SCF_FBW7_2

Location: 226:232

E3 ligase: FBXW7

DEGRON score: 0.9652

ASA_SCORE: 95.3571

COIL: 0.9374

CONS_SCORE: 0.3191

DSS_SCORE: 0.3781

HELIX: 0.021

FCONS_SCORE: 1.05

RIG_SCORE: 0.6969

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V218F	TCGA-43-2581	LUSC	TCGA	LYTPPPE	DEG_SCF_FBW7_2	0.1111
p.V218F	DO26602	LUSC	ICGC	LYTPPPE	DEG_SCF_FBW7_2	0.1111
p.H223Y	TCGA-AG-4009	READ	TCGA	LYTPPPE	DEG_SCF_FBW7_2	0.25
p.H223Y	DO36961	READ	ICGC	LYTPPPE	DEG_SCF_FBW7_2	0.25
p.H242R	TCGA-CG-5721	STAD	TCGA	LYTPPPE	DEG_SCF_FBW7_2	0.0556
p.P241L	TCGA-EE-A29E	SKCM	TCGA	LYTPPPE	DEG_SCF_FBW7_2	0.0833
p.E232Q	TCGA-LT-A5Z6	BLCA	TCGA	LYTPPPE	DEG_SCF_FBW7_2	0.6744
p.E232Q	DO44029	BLCA	ICGC	LYTPPPE	DEG_SCF_FBW7_2	0.6744
p.P216A	DO228416	LICA	ICGC	LYTPPPE	DEG_SCF_FBW7_2	0.0556
p.P230L	DO50805	LIRI	ICGC	LYTPPPE	DEG_SCF_FBW7_2	0.6471
p.P216S	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	LYTPPPE	DEG_SCF_FBW7_2	0.0556
p.P216S	ACH-000875	Lung Cancer	CCLE	LYTPPPE	DEG_SCF_FBW7_2	0.0556
p.P216S	NCI-H2347	lung	COSMIC	LYTPPPE	DEG_SCF_FBW7_2	0.0556

Drug responses associated with BRD2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	JQ1	0.338
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	I-BET-762	2.9946
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	JQ1	0.3785
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	I-BET-762	2.1256
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	OTX015	0.4581
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	JQ1	42.7375
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	I-BET-762	252.4732
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	JQ1	21.9324
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	I-BET-762	106.84
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	OTX015	78.131
SIDM00661	DLBC\|B_cell_lymphoma	p.N748S (No)	GDSC	JQ1	1.2088
SIDM00661	DLBC\|B_cell_lymphoma	p.N748S (No)	GDSC	I-BET-762	2.6133
SIDM00661	DLBC\|B_cell_lymphoma	p.N748S (No)	GDSC	JQ1	0.8621
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	JQ1	0.2229
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	I-BET-762	433.4615
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	JQ1	12.6634
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	I-BET-762	18.887
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	OTX015	2.9339
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	JQ1	1.0416
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	I-BET-762	25.1531
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	JQ1	2.8509
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	I-BET-762	36.989
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	OTX015	18.225
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	JQ1	1.035
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	I-BET-762	11.5453
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	JQ1	21.0914
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	I-BET-762	22.924
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	OTX015	3.8966
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	JQ1	78.9202
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	I-BET-762	220.0569
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	JQ1	31.3189
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	I-BET-762	245.98
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	OTX015	271.2
SIDM00318	KIRC\|kidney	p.A766T (No)	GDSC	JQ1	0.4368
SIDM00318	KIRC\|kidney	p.A766T (No)	GDSC	I-BET-762	156.5988
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A17V (No)	GDSC	JQ1	1.7031
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A17V (No)	GDSC	I-BET-762	9.0749
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A17V (No)	GDSC	OTX015	6.8733
SIDM00151	OV\|ovary	p.F145fs*20 (No)	GDSC	JQ1	22.7238
SIDM00151	OV\|ovary	p.F145fs*20 (No)	GDSC	I-BET-762	9.7528
SIDM00151	OV\|ovary	p.F145fs*20 (No)	GDSC	OTX015	3.6257
SIDM00044	HNSC\|head_and_neck	p.A766T (No)	GDSC	JQ1	43.1291
SIDM00044	HNSC\|head_and_neck	p.A766T (No)	GDSC	I-BET-762	370.1414
SIDM00044	HNSC\|head_and_neck	p.A766T (No)	GDSC	JQ1	19.9746
SIDM00251	STAD\|stomach	p.P471fs*50 (No)	GDSC	JQ1	6.3107
SIDM00251	STAD\|stomach	p.P471fs*50 (No)	GDSC	I-BET-762	105.237
SIDM00251	STAD\|stomach	p.P471fs*50 (No)	GDSC	JQ1	4.1863
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	JQ1	0.2744
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	I-BET-762	1.0054
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	JQ1	7.1926
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	I-BET-762	7.8467
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	OTX015	7.885
SIDM00689	DLBC\|B_cell_lymphoma	p.W136* (No)	GDSC	JQ1	0.4375
SIDM00689	DLBC\|B_cell_lymphoma	p.W136* (No)	GDSC	I-BET-762	2.1987
SIDM00689	DLBC\|B_cell_lymphoma	p.W136* (No)	GDSC	JQ1	4.4174
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	JQ1	3.4367
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	I-BET-762	114.2188
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	JQ1	4.869
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	I-BET-762	260.84
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	OTX015	42.102
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	JQ1	40.792
SIDM00082	SKCM\|melanoma	p.A766T (No)	GDSC	JQ1	2.6614
SIDM00082	SKCM\|melanoma	p.A766T (No)	GDSC	I-BET-762	287.9299
SIDM00082	SKCM\|melanoma	p.A766T (No)	GDSC	JQ1	9.75
SIDM00082	SKCM\|melanoma	p.A766T (No)	GDSC	I-BET-762	85.054
SIDM00082	SKCM\|melanoma	p.A766T (No)	GDSC	OTX015	116.85
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	JQ1	0.9507
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	I-BET-762	5.5114
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	JQ1	0.3938
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	I-BET-762	2.9656
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	OTX015	0.6297
SIDM01141	OV\|ovary	p.A766T (No)	GDSC	JQ1	1.5933
SIDM01141	OV\|ovary	p.A766T (No)	GDSC	I-BET-762	49.8631
SIDM01141	OV\|ovary	p.A766T (No)	GDSC	JQ1	15.1653
SIDM01141	OV\|ovary	p.A766T (No)	GDSC	I-BET-762	54.558
SIDM01141	OV\|ovary	p.A766T (No)	GDSC	OTX015	21.698
SIDM00216	COREAD\|large_intestine	p.E522G (No)	GDSC	I-BET-762	2.1779
SIDM00216	COREAD\|large_intestine	p.E522G (No)	GDSC	I-BET-762	6.6864
SIDM00216	COREAD\|large_intestine	p.E522G (No)	GDSC	OTX015	5.0449
SIDM01186	BRCA\|breast	p.E513fs*19 (No)	GDSC	JQ1	2.5778
SIDM01186	BRCA\|breast	p.E513fs*19 (No)	GDSC	I-BET-762	149.0211
SIDM01186	BRCA\|breast	p.E513fs*19 (No)	GDSC	JQ1	18.9828
SIDM01186	BRCA\|breast	p.E513fs*19 (No)	GDSC	JQ1	39.022
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	JQ1	2.5551
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	I-BET-762	53.3819
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	JQ1	13.5696
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	I-BET-762	58.836
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	OTX015	29.1
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	JQ1	0.641
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	I-BET-762	201.9926
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	JQ1	9.0853
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	I-BET-762	19.258
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	OTX015	5.1627
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	JQ1	6.0137
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	I-BET-762	62.1037
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	JQ1	12.8765
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	I-BET-762	133.6
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	OTX015	224.7
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	OTX015	7.248
SIDM01147	STAD\|stomach	p.H83Q (No)	GDSC	JQ1	24.9041
SIDM01147	STAD\|stomach	p.H83Q (No)	GDSC	I-BET-762	11.04
SIDM01147	STAD\|stomach	p.H83Q (No)	GDSC	OTX015	8.5555
SIDM00973	SKCM\|melanoma	p.A766T (No)	GDSC	JQ1	0.1875
SIDM00973	SKCM\|melanoma	p.A766T (No)	GDSC	I-BET-762	10.9899
SIDM00973	SKCM\|melanoma	p.A766T (No)	GDSC	JQ1	11.8757
SIDM00973	SKCM\|melanoma	p.A766T (No)	GDSC	I-BET-762	15.191
SIDM00973	SKCM\|melanoma	p.A766T (No)	GDSC	OTX015	22.167
SIDM00238	OV\|ovary	p.E506_S507insE (No)	GDSC	I-BET-762	314.0424
SIDM00238	OV\|ovary	p.E506_S507insE (No)	GDSC	JQ1	14.1477
SIDM00238	OV\|ovary	p.E506_S507insE (No)	GDSC	I-BET-762	218.79
SIDM00238	OV\|ovary	p.E506_S507insE (No)	GDSC	OTX015	100.87
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (No)	GDSC	JQ1	7.4871
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (No)	GDSC	I-BET-762	608.9262
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (No)	GDSC	JQ1	6.2721
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (No)	GDSC	I-BET-762	59.017
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (No)	GDSC	OTX015	537.31
SIDM01261	BRCA\|breast	p.S7L (No)	GDSC	I-BET-762	97.6715
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	JQ1	0.7323
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	I-BET-762	286.8657
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	JQ1	4.1512
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	I-BET-762	298.43
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	OTX015	55.349
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S256C (No)	GDSC	JQ1	0.3436
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S256C (No)	GDSC	I-BET-762	336.8312
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S256C (No)	GDSC	JQ1	13.1372
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	JQ1	0.2695
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	I-BET-762	1.3284
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	JQ1	0.7693
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	I-BET-762	2.5438
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	OTX015	0.5581
SIDM00934	PAAD\|pancreas	p.A766T (No)	GDSC	JQ1	2.5914
SIDM00934	PAAD\|pancreas	p.A766T (No)	GDSC	I-BET-762	46.4602
SIDM00934	PAAD\|pancreas	p.A766T (No)	GDSC	I-BET-762	157.94
SIDM00934	PAAD\|pancreas	p.A766T (No)	GDSC	OTX015	144.95
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.P216S (Yes)	GDSC	JQ1	0.937
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.P216S (Yes)	GDSC	I-BET-762	162.708
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.P216S (Yes)	GDSC	JQ1	16.4233
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	JQ1	0.7264
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	I-BET-762	163.4619
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	JQ1	3.1453
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	I-BET-762	14.646
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	OTX015	1.4241
SIDM00222	MESO\|mesothelioma	p.A766T (No)	GDSC	JQ1	5.6541
SIDM00222	MESO\|mesothelioma	p.A766T (No)	GDSC	I-BET-762	5.5699
SIDM00222	MESO\|mesothelioma	p.A766T (No)	GDSC	JQ1	19.0767
SIDM00222	MESO\|mesothelioma	p.A766T (No)	GDSC	I-BET-762	8.5939
SIDM00222	MESO\|mesothelioma	p.A766T (No)	GDSC	OTX015	6.3419
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	JQ1	0.5022
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	I-BET-762	1.8887
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	JQ1	2.2668
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	I-BET-762	4.003
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	OTX015	1.1727
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	JQ1	2.7845
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	I-BET-762	71.8758
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	JQ1	8.9974
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	I-BET-762	17.667
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	OTX015	9.1906
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	JQ1	4.1871
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	JQ1	44.9286
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	I-BET-762	386.7378
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	JQ1	15.3448
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	I-BET-762	110.91
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	OTX015	73.72
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	JQ1	284.17
SIDM00086	KIRC\|kidney	p.A766T (No)	GDSC	JQ1	14.8159
SIDM00086	KIRC\|kidney	p.A766T (No)	GDSC	I-BET-762	515.8474
SIDM00086	KIRC\|kidney	p.A766T (No)	GDSC	JQ1	20.0699
SIDM00086	KIRC\|kidney	p.A766T (No)	GDSC	I-BET-762	169.69
SIDM00086	KIRC\|kidney	p.A766T (No)	GDSC	OTX015	127.47

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LYTPPPE

Degron related mutations and impact score

Drug responses associated with BRD2 mutations

All proteins holding degron of LYTPPPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25440	Bromodomain-containing protein 2	DEG_SCF_FBW7_2	226:232	LYTPPPE	FBXW7	0.9652	More...