DegronMD

Uniprot ID: P25440

Source protein: Bromodomain-containing protein 2

Source gene: BRD2

Class: DEG_SPOP_SBC_1

Location: 474:478

E3 ligase: SPOP

DEGRON score: 0.6808

ASA_SCORE: 87.3

COIL: 0.9084

CONS_SCORE: 0.3703

DSS_SCORE: 0.7776

HELIX: 0.0708

FCONS_SCORE: 1.1084

RIG_SCORE: 0.5014

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S482G	TCGA-AA-3821	COAD	TCGA	AKSSS	DEG_SPOP_SBC_1	0.2222
p.S482G	DO9314	COAD	ICGC	AKSSS	DEG_SPOP_SBC_1	0.2222
p.S466F	TCGA-CU-A72E	BLCA	TCGA	AKSSS	DEG_SPOP_SBC_1	0.1111
p.S466F	DO49734	BLCA	ICGC	AKSSS	DEG_SPOP_SBC_1	0.1111
p.S486I	TCGA-DX-A6YV	SARC	TCGA	AKSSS	DEG_SPOP_SBC_1	0.1111
p.S486I	DO220011	SARC	ICGC	AKSSS	DEG_SPOP_SBC_1	0.1111
p.S476L	TCGA-HU-A4GX	STAD	TCGA	AKSSS	DEG_SPOP_SBC_1	0.7667
p.S476L	DO47757	STAD	ICGC	AKSSS	DEG_SPOP_SBC_1	0.7667
p.E475G	SNU-175	large_intestine	COSMIC	AKSSS	DEG_SPOP_SBC_1	0.7199

Drug responses associated with BRD2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	JQ1	0.338
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	I-BET-762	2.9946
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	JQ1	0.3785
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	I-BET-762	2.1256
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	OTX015	0.4581
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	JQ1	42.7375
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	I-BET-762	252.4732
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	JQ1	21.9324
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	I-BET-762	106.84
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	OTX015	78.131
SIDM00661	DLBC\|B_cell_lymphoma	p.N748S (No)	GDSC	JQ1	1.2088
SIDM00661	DLBC\|B_cell_lymphoma	p.N748S (No)	GDSC	I-BET-762	2.6133
SIDM00661	DLBC\|B_cell_lymphoma	p.N748S (No)	GDSC	JQ1	0.8621
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	JQ1	0.2229
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	I-BET-762	433.4615
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	JQ1	12.6634
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	I-BET-762	18.887
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	OTX015	2.9339
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	JQ1	1.0416
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	I-BET-762	25.1531
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	JQ1	2.8509
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	I-BET-762	36.989
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	OTX015	18.225
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	JQ1	1.035
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	I-BET-762	11.5453
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	JQ1	21.0914
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	I-BET-762	22.924
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	OTX015	3.8966
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	JQ1	78.9202
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	I-BET-762	220.0569
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	JQ1	31.3189
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	I-BET-762	245.98
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	OTX015	271.2
SIDM00318	KIRC\|kidney	p.A766T (No)	GDSC	JQ1	0.4368
SIDM00318	KIRC\|kidney	p.A766T (No)	GDSC	I-BET-762	156.5988
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A17V (No)	GDSC	JQ1	1.7031
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A17V (No)	GDSC	I-BET-762	9.0749
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A17V (No)	GDSC	OTX015	6.8733
SIDM00151	OV\|ovary	p.F145fs*20 (No)	GDSC	JQ1	22.7238
SIDM00151	OV\|ovary	p.F145fs*20 (No)	GDSC	I-BET-762	9.7528
SIDM00151	OV\|ovary	p.F145fs*20 (No)	GDSC	OTX015	3.6257
SIDM00044	HNSC\|head_and_neck	p.A766T (No)	GDSC	JQ1	43.1291
SIDM00044	HNSC\|head_and_neck	p.A766T (No)	GDSC	I-BET-762	370.1414
SIDM00044	HNSC\|head_and_neck	p.A766T (No)	GDSC	JQ1	19.9746
SIDM00251	STAD\|stomach	p.P471fs*50 (Yes)	GDSC	JQ1	6.3107
SIDM00251	STAD\|stomach	p.P471fs*50 (Yes)	GDSC	I-BET-762	105.237
SIDM00251	STAD\|stomach	p.P471fs*50 (Yes)	GDSC	JQ1	4.1863
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	JQ1	0.2744
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	I-BET-762	1.0054
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	JQ1	7.1926
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	I-BET-762	7.8467
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	OTX015	7.885
SIDM00689	DLBC\|B_cell_lymphoma	p.W136* (No)	GDSC	JQ1	0.4375
SIDM00689	DLBC\|B_cell_lymphoma	p.W136* (No)	GDSC	I-BET-762	2.1987
SIDM00689	DLBC\|B_cell_lymphoma	p.W136* (No)	GDSC	JQ1	4.4174
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	JQ1	3.4367
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	I-BET-762	114.2188
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	JQ1	4.869
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	I-BET-762	260.84
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	OTX015	42.102
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	JQ1	40.792
SIDM00082	SKCM\|melanoma	p.A766T (No)	GDSC	JQ1	2.6614
SIDM00082	SKCM\|melanoma	p.A766T (No)	GDSC	I-BET-762	287.9299
SIDM00082	SKCM\|melanoma	p.A766T (No)	GDSC	JQ1	9.75
SIDM00082	SKCM\|melanoma	p.A766T (No)	GDSC	I-BET-762	85.054
SIDM00082	SKCM\|melanoma	p.A766T (No)	GDSC	OTX015	116.85
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	JQ1	0.9507
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	I-BET-762	5.5114
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	JQ1	0.3938
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	I-BET-762	2.9656
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	OTX015	0.6297
SIDM01141	OV\|ovary	p.A766T (No)	GDSC	JQ1	1.5933
SIDM01141	OV\|ovary	p.A766T (No)	GDSC	I-BET-762	49.8631
SIDM01141	OV\|ovary	p.A766T (No)	GDSC	JQ1	15.1653
SIDM01141	OV\|ovary	p.A766T (No)	GDSC	I-BET-762	54.558
SIDM01141	OV\|ovary	p.A766T (No)	GDSC	OTX015	21.698
SIDM00216	COREAD\|large_intestine	p.E522G (No)	GDSC	I-BET-762	2.1779
SIDM00216	COREAD\|large_intestine	p.E522G (No)	GDSC	I-BET-762	6.6864
SIDM00216	COREAD\|large_intestine	p.E522G (No)	GDSC	OTX015	5.0449
SIDM01186	BRCA\|breast	p.E513fs*19 (No)	GDSC	JQ1	2.5778
SIDM01186	BRCA\|breast	p.E513fs*19 (No)	GDSC	I-BET-762	149.0211
SIDM01186	BRCA\|breast	p.E513fs*19 (No)	GDSC	JQ1	18.9828
SIDM01186	BRCA\|breast	p.E513fs*19 (No)	GDSC	JQ1	39.022
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	JQ1	2.5551
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	I-BET-762	53.3819
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	JQ1	13.5696
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	I-BET-762	58.836
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	OTX015	29.1
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	JQ1	0.641
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	I-BET-762	201.9926
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	JQ1	9.0853
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	I-BET-762	19.258
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	OTX015	5.1627
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	JQ1	6.0137
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	I-BET-762	62.1037
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	JQ1	12.8765
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	I-BET-762	133.6
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	OTX015	224.7
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	OTX015	7.248
SIDM01147	STAD\|stomach	p.H83Q (No)	GDSC	JQ1	24.9041
SIDM01147	STAD\|stomach	p.H83Q (No)	GDSC	I-BET-762	11.04
SIDM01147	STAD\|stomach	p.H83Q (No)	GDSC	OTX015	8.5555
SIDM00973	SKCM\|melanoma	p.A766T (No)	GDSC	JQ1	0.1875
SIDM00973	SKCM\|melanoma	p.A766T (No)	GDSC	I-BET-762	10.9899
SIDM00973	SKCM\|melanoma	p.A766T (No)	GDSC	JQ1	11.8757
SIDM00973	SKCM\|melanoma	p.A766T (No)	GDSC	I-BET-762	15.191
SIDM00973	SKCM\|melanoma	p.A766T (No)	GDSC	OTX015	22.167
SIDM00238	OV\|ovary	p.E506_S507insE (No)	GDSC	I-BET-762	314.0424
SIDM00238	OV\|ovary	p.E506_S507insE (No)	GDSC	JQ1	14.1477
SIDM00238	OV\|ovary	p.E506_S507insE (No)	GDSC	I-BET-762	218.79
SIDM00238	OV\|ovary	p.E506_S507insE (No)	GDSC	OTX015	100.87
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (No)	GDSC	JQ1	7.4871
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (No)	GDSC	I-BET-762	608.9262
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (No)	GDSC	JQ1	6.2721
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (No)	GDSC	I-BET-762	59.017
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (No)	GDSC	OTX015	537.31
SIDM01261	BRCA\|breast	p.S7L (No)	GDSC	I-BET-762	97.6715
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	JQ1	0.7323
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	I-BET-762	286.8657
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	JQ1	4.1512
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	I-BET-762	298.43
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	OTX015	55.349
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S256C (No)	GDSC	JQ1	0.3436
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S256C (No)	GDSC	I-BET-762	336.8312
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S256C (No)	GDSC	JQ1	13.1372
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	JQ1	0.2695
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	I-BET-762	1.3284
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	JQ1	0.7693
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	I-BET-762	2.5438
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	OTX015	0.5581
SIDM00934	PAAD\|pancreas	p.A766T (No)	GDSC	JQ1	2.5914
SIDM00934	PAAD\|pancreas	p.A766T (No)	GDSC	I-BET-762	46.4602
SIDM00934	PAAD\|pancreas	p.A766T (No)	GDSC	I-BET-762	157.94
SIDM00934	PAAD\|pancreas	p.A766T (No)	GDSC	OTX015	144.95
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.P216S (No)	GDSC	JQ1	0.937
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.P216S (No)	GDSC	I-BET-762	162.708
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.P216S (No)	GDSC	JQ1	16.4233
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	JQ1	0.7264
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	I-BET-762	163.4619
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	JQ1	3.1453
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	I-BET-762	14.646
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	OTX015	1.4241
SIDM00222	MESO\|mesothelioma	p.A766T (No)	GDSC	JQ1	5.6541
SIDM00222	MESO\|mesothelioma	p.A766T (No)	GDSC	I-BET-762	5.5699
SIDM00222	MESO\|mesothelioma	p.A766T (No)	GDSC	JQ1	19.0767
SIDM00222	MESO\|mesothelioma	p.A766T (No)	GDSC	I-BET-762	8.5939
SIDM00222	MESO\|mesothelioma	p.A766T (No)	GDSC	OTX015	6.3419
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	JQ1	0.5022
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	I-BET-762	1.8887
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	JQ1	2.2668
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	I-BET-762	4.003
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	OTX015	1.1727
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	JQ1	2.7845
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	I-BET-762	71.8758
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	JQ1	8.9974
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	I-BET-762	17.667
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	OTX015	9.1906
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	JQ1	4.1871
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	JQ1	44.9286
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	I-BET-762	386.7378
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	JQ1	15.3448
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	I-BET-762	110.91
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	OTX015	73.72
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	JQ1	284.17
SIDM00086	KIRC\|kidney	p.A766T (No)	GDSC	JQ1	14.8159
SIDM00086	KIRC\|kidney	p.A766T (No)	GDSC	I-BET-762	515.8474
SIDM00086	KIRC\|kidney	p.A766T (No)	GDSC	JQ1	20.0699
SIDM00086	KIRC\|kidney	p.A766T (No)	GDSC	I-BET-762	169.69
SIDM00086	KIRC\|kidney	p.A766T (No)	GDSC	OTX015	127.47

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_SPOP_SBC_1	1432:1436	AKSSS	SPOP	0.9644	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	1217:1221	AKSSS	SPOP	0.9576	More...
O94762	ATP-dependent DNA helicase Q5	DEG_SPOP_SBC_1	732:736	AKSSS	SPOP	0.7563	More...
O95294	RasGAP-activating-like protein 1	DEG_SPOP_SBC_1	2:6	AKSSS	SPOP	0.7406	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	474:478	AKSSS	SPOP	0.6808	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	282:286	AKSSS	SPOP	0.9674	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1165:1169	AKSSS	SPOP	0.9726	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	755:759	AKSSS	SPOP	0.5292	More...
Q6PRD1	Probable G-protein coupled receptor 179	DEG_SPOP_SBC_1	906:910	AKSSS	SPOP	0.9545	More...
Q8NEY1	Neuron navigator 1	DEG_SPOP_SBC_1	677:681	AKSSS	SPOP	0.9854	More...
Q96PV6	Leukocyte receptor cluster member 8	DEG_SPOP_SBC_1	59:63	AKSSS	SPOP	0.9898	More...
Q9NWH9	SAFB-like transcription modulator	DEG_SPOP_SBC_1	351:355	AKSSS	SPOP	0.9894	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_SPOP_SBC_1	167:171	AKSSS	SPOP	0.989	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	698:702	AKSSS	SPOP	0.9382	More...
Q9Y692	Glucocorticoid modulatory element-binding protein 1	DEG_SPOP_SBC_1	455:459	AKSSS	SPOP	0.8751	More...
Q2TAC6	Kinesin-like protein KIF19	DEG_SPOP_SBC_1	720:724	AKSSS	SPOP	0.9422	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	203:207	AKSSS	SPOP	0.9219	More...
Q5SYE7	NHS-like protein 1	DEG_SPOP_SBC_1	1146:1150	AKSSS	SPOP	0.9831	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	676:680	AKSSS	SPOP	0.9984	More...
A6NCF6	Putative MAGE domain-containing protein MAGEA13P	DEG_SPOP_SBC_1	332:336	AKSSS	SPOP	0.9368	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKSSS

Degron related mutations and impact score

Drug responses associated with BRD2 mutations

All proteins holding degron of AKSSS