DegronMD - Q5SYE7(NHSL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H573N	TCGA-A5-A0G1	UCEC	TCGA	LATPGYS	DEG_SCF_FBW7_1	574:580	Mutation rewiring degron network	0.3056
p.H573N	DO42472	UCEC	ICGC	LATPGYS	DEG_SCF_FBW7_1	574:580	Mutation rewiring degron network	0.3056
p.E1326D	TCGA-A5-A2K2	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.2222
p.E1326D	DO40859	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.2222
p.P1013T	TCGA-AP-A059	UCEC	TCGA	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation rewiring degron network	0.1111
p.P1013T	DO41361	UCEC	ICGC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation rewiring degron network	0.1111
p.D609N	TCGA-AP-A1DV	UCEC	TCGA	DSGHGS	DEG_SCF_TRCP1_1	618:623	Mutation rewiring degron network	0.0833
p.D609N	DO43186	UCEC	ICGC	DSGHGS	DEG_SCF_TRCP1_1	618:623	Mutation rewiring degron network	0.0833
p.R998H	TCGA-EI-6917	READ	TCGA	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.8244
p.R998H	DO32863	PACA	ICGC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.8244
p.R998H	DO36881	READ	ICGC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.8244
p.A613S	TCGA-F4-6570	COAD	TCGA	DSGHGS	DEG_SCF_TRCP1_1	618:623	Mutation rewiring degron network	0.1944
p.A613S	DO10443	COAD	ICGC	DSGHGS	DEG_SCF_TRCP1_1	618:623	Mutation rewiring degron network	0.1944
p.S1148T	DO228483	BRCA	ICGC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation altering degron motif	0.6005
p.S1148T	DO228483	BRCA	ICGC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation altering degron motif	0.6005
p.S1148T	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation altering degron motif	0.6005
p.S1148T	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation altering degron motif	0.6005
p.S1148T	SIDM00573	Glioblastoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation altering degron motif	0.6005
p.S1148T	SIDM00573	Glioblastoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation altering degron motif	0.6005
p.S1148T	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation altering degron motif	0.6005
p.S1148T	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation altering degron motif	0.6005
p.S1148T	SIDM00530	Esophageal Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation altering degron motif	0.6005
p.S1148T	SIDM00530	Esophageal Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation altering degron motif	0.6005
p.S1148T	SIDM00821	Kidney Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation altering degron motif	0.6005
p.S1148T	SIDM00821	Kidney Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation altering degron motif	0.6005
p.S1148T	SIDM00599	Osteosarcoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation altering degron motif	0.6005
p.S1148T	SIDM00599	Osteosarcoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation altering degron motif	0.6005
p.S1148T	SIDM00986	Head and Neck Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation altering degron motif	0.6005
p.S1148T	SIDM00986	Head and Neck Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation altering degron motif	0.6005
p.S1148T	SIDM00996	Thyroid Gland Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation altering degron motif	0.6005
p.S1148T	SIDM00996	Thyroid Gland Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation altering degron motif	0.6005
p.S1148T	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation altering degron motif	0.6005
p.S1148T	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation altering degron motif	0.6005
p.S1148T	SIDM00302	Other Solid Cancers	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation altering degron motif	0.6005
p.S1148T	SIDM00302	Other Solid Cancers	GDSC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation altering degron motif	0.6005
p.N180K	DO8264	COAD	ICGC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.6918
p.A1157V	DO222755	COCA	ICGC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation rewiring degron network	0.0833
p.A1157V	DO222755	COCA	ICGC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation rewiring degron network	0.1389
p.T576P	DO233917	GACA	ICGC	LATPGYS	DEG_SCF_FBW7_1	574:580	Mutation altering degron motif	0.7031
p.P1015T	DO228971	LICA	ICGC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation rewiring degron network	0.0556
p.T1327N	DO229009	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.25
p.P997S	DO222868	MELA	ICGC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.5641
p.P1013S	DO232224	PBCA	ICGC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation rewiring degron network	0.1111
p.R189L	DO229248	THCA	ICGC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.1944
p.R188W	DO43306	UCEC	ICGC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.2222
p.A1336T	SIDM02039	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.2778
p.V615A	SIDM01307	Colorectal Carcinoma	GDSC	DSGHGS	DEG_SCF_TRCP1_1	618:623	Mutation rewiring degron network	0.25
p.P1135A	SIDM00845	Burkitt's Lymphoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation rewiring degron network	0.1389
p.R183H	SIDM00569	Osteosarcoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.8244
p.R183H	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.8244
p.R183H	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.8244
p.R183H	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.8244
p.R183H	NY	bone	COSMIC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.8244
p.R183H	TE-8	oesophagus	COSMIC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.8244
p.R183H	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.8244
p.R183H	EC-GI-10	oesophagus	COSMIC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.8244
p.G1155D	SIDM00660	Colorectal Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation rewiring degron network	0.1389
p.G1155D	SIDM00660	Colorectal Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation rewiring degron network	0.1944
p.G1155D	SIDM00794	Other Solid Cancers	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation rewiring degron network	0.1389
p.G1155D	SIDM00794	Other Solid Cancers	GDSC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation rewiring degron network	0.1944
p.G1155D	A388	skin	COSMIC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation rewiring degron network	0.1389
p.G1155D	A388	skin	COSMIC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation rewiring degron network	0.1944
p.G1155D	LS-411N	large intestine	COSMIC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation rewiring degron network	0.1389
p.G1155D	LS-411N	large intestine	COSMIC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation rewiring degron network	0.1944
p.G1344R	SIDM00282	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.0556
p.G1344R	SIDM00383	Gastric Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.0556
p.G1344R	ACH-000237	Ovarian Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.0556
p.G1344R	ACH-000909	Endometrial/Uterine Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.0556
p.G1344R	ACH-000998	Colon/Colorectal Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.0556
p.S1333F	SIDM00562	Breast Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation altering degron motif	0.7982
p.S1333F	ACH-002163	Breast Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation altering degron motif	0.7982
p.S1333F	MRK-nu-1	breast	COSMIC	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation altering degron motif	0.7982
p.T191I	SIDM00489	Oral Cavity Carcinoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.1389
p.T191I	ACH-002043	Head and Neck Cancer	CCLE	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.1389
p.T191I	Ca9-22	upper aerodigestive tract	COSMIC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.1389
p.P1143L	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation altering degron motif	0.6471
p.D182N	SIDM00241	Breast Carcinoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.6932
p.D182N	OCUB-M	breast	COSMIC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.6932
p.P1003R	SIDM00363	Acute Myeloid Leukemia	GDSC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.6401
p.P1003R	SIDM00316	Glioblastoma	GDSC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.6401
p.P1003R	SIDM00503	Gastric Carcinoma	GDSC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.6401
p.P1003R	YH-13	central nervous system	COSMIC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.6401
p.P1003R	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.6401
p.P1003R	FU97	stomach	COSMIC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.6401
p.F186V	SIDM00118	Colorectal Carcinoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.2778
p.F186V	ACH-001081	Colon/Colorectal Cancer	CCLE	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.2778
p.F186V	HCC2998	large intestine	COSMIC	PKTPASS	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.2778
p.R566G	ACH-000634	Brain Cancer	CCLE	LATPGYS	DEG_SCF_FBW7_1	574:580	Mutation rewiring degron network	0.1111
p.P1013L	ACH-000665	Lung Cancer	CCLE	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation rewiring degron network	0.1111
p.T617A	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGHGS	DEG_SCF_TRCP1_1	618:623	Mutation rewiring degron network	0.3056
p.C987F	ACH-001443	Thyroid Cancer	CCLE	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation rewiring degron network	0.0556
p.R1160C	ACH-001484	Leukemia	CCLE	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation rewiring degron network	0.0556
p.R1160C	ACH-001485	Leukemia	CCLE	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation rewiring degron network	0.0556
p.S568P	ACH-001669	Leukemia	CCLE	LATPGYS	DEG_SCF_FBW7_1	574:580	Mutation rewiring degron network	0.1667
p.S568P	ACH-002238	Leukemia	CCLE	LATPGYS	DEG_SCF_FBW7_1	574:580	Mutation rewiring degron network	0.1667
p.S568P	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LATPGYS	DEG_SCF_FBW7_1	574:580	Mutation rewiring degron network	0.1667
p.P999R	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.6401
p.P999R	FU97	stomach	COSMIC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.6401
p.P999R	YH-13	central nervous system	COSMIC	PRPALSPIL	DEG_APCC_DBOX_1	997:1005	Mutation altering degron motif	0.6401
p.D1342E	T-T	oesophagus	COSMIC	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.1111
p.G1151D	A388	skin	COSMIC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation rewiring degron network	0.25
p.G1151D	A388	skin	COSMIC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation rewiring degron network	0.3056
p.G1151D	LS-411N	large intestine	COSMIC	LPTPAKS	DEG_SCF_FBW7_1	1142:1148	Mutation rewiring degron network	0.25
p.G1151D	LS-411N	large intestine	COSMIC	AKSSS	DEG_SPOP_SBC_1	1146:1150	Mutation rewiring degron network	0.3056
p.S1329F	MRK-nu-1	breast	COSMIC	AGSSS	DEG_SPOP_SBC_1	1330:1334	Mutation rewiring degron network	0.3056
p.S564P	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LATPGYS	DEG_SCF_FBW7_1	574:580	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NHSL1

UniProt ID: Q5SYE7

Entrez ID: 57224

Protein name: NHS-like protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NHSL1 in