DegronMD

Uniprot ID: Q5SYE7

Source protein: NHS-like protein 1

Source gene: NHSL1

Class: DEG_SCF_FBW7_1

Location: 574:580

E3 ligase: FBXW7

DEGRON score: 0.9393

ASA_SCORE: 87.1714

COIL: 0.9293

CONS_SCORE: 0.4597

DSS_SCORE: 0.6016

HELIX: 0.0264

FCONS_SCORE: 0.9353

RIG_SCORE: 0.6186

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T576P	DO233917	GACA	ICGC	LATPGYS	DEG_SCF_FBW7_1	0.7031
p.H573N	TCGA-A5-A0G1	UCEC	TCGA	LATPGYS	DEG_SCF_FBW7_1	0.3056
p.H573N	DO42472	UCEC	ICGC	LATPGYS	DEG_SCF_FBW7_1	0.3056
p.S568P	ACH-001669	Leukemia	CCLE	LATPGYS	DEG_SCF_FBW7_1	0.1667
p.S568P	ACH-002238	Leukemia	CCLE	LATPGYS	DEG_SCF_FBW7_1	0.1667
p.S568P	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LATPGYS	DEG_SCF_FBW7_1	0.1667
p.R566G	ACH-000634	Brain Cancer	CCLE	LATPGYS	DEG_SCF_FBW7_1	0.1111
p.S564P	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LATPGYS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SYE7	NHS-like protein 1	DEG_SCF_FBW7_1	574:580	LATPGYS	FBXW7	0.9393	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons