DegronMD

Uniprot ID: Q5SYE7

Source protein: NHS-like protein 1

Source gene: NHSL1

Class: DEG_SCF_FBW7_1

Location: 1142:1148

E3 ligase: FBXW7

DEGRON score: 0.9501

ASA_SCORE: 90.9286

COIL: 0.953

CONS_SCORE: 0.4275

DSS_SCORE: 0.7503

HELIX: 0.0219

FCONS_SCORE: 0.9894

RIG_SCORE: 0.5523

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1148T	DO228483	BRCA	ICGC	LPTPAKS	DEG_SCF_FBW7_1	0.6005
p.S1148T	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.6005
p.S1148T	SIDM00573	Glioblastoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.6005
p.S1148T	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.6005
p.S1148T	SIDM00530	Esophageal Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.6005
p.S1148T	SIDM00821	Kidney Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.6005
p.S1148T	SIDM00599	Osteosarcoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.6005
p.S1148T	SIDM00986	Head and Neck Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.6005
p.S1148T	SIDM00996	Thyroid Gland Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.6005
p.S1148T	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.6005
p.S1148T	SIDM00302	Other Solid Cancers	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.6005
p.A1157V	DO222755	COCA	ICGC	LPTPAKS	DEG_SCF_FBW7_1	0.0833
p.P1135A	SIDM00845	Burkitt's Lymphoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.1389
p.G1155D	SIDM00660	Colorectal Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.1389
p.G1155D	SIDM00794	Other Solid Cancers	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.1389
p.G1155D	A388	skin	COSMIC	LPTPAKS	DEG_SCF_FBW7_1	0.1389
p.G1155D	LS-411N	large_intestine	COSMIC	LPTPAKS	DEG_SCF_FBW7_1	0.1389
p.P1143L	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	LPTPAKS	DEG_SCF_FBW7_1	0.6471
p.G1151D	A388	skin	COSMIC	LPTPAKS	DEG_SCF_FBW7_1	0.25
p.G1151D	LS-411N	large_intestine	COSMIC	LPTPAKS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SYE7	NHS-like protein 1	DEG_SCF_FBW7_1	1142:1148	LPTPAKS	FBXW7	0.9501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons