DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRPALSPIL
Uniprot ID:
Q5SYE7
Source protein:
NHS-like protein 1
Source gene:
NHSL1
Class:
DEG_APCC_DBOX_1
Location:
997:1005
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8764
ASA_SCORE:
100.9
COIL:
0.9643
CONS_SCORE:
0.4519
DSS_SCORE:
0.4216
HELIX:
0.0146
FCONS_SCORE:
1.0227
RIG_SCORE:
0.6371
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P1013T
TCGA-AP-A059
UCEC
TCGA
PRPALSPIL
DEG_APCC_DBOX_1
0.1111
p.P1013T
DO41361
UCEC
ICGC
PRPALSPIL
DEG_APCC_DBOX_1
0.1111
p.R998H
TCGA-EI-6917
READ
TCGA
PRPALSPIL
DEG_APCC_DBOX_1
0.8244
p.R998H
DO32863
PACA
ICGC
PRPALSPIL
DEG_APCC_DBOX_1
0.8244
p.R998H
DO36881
READ
ICGC
PRPALSPIL
DEG_APCC_DBOX_1
0.8244
p.P1015T
DO228971
LICA
ICGC
PRPALSPIL
DEG_APCC_DBOX_1
0.0556
p.P997S
DO222868
MELA
ICGC
PRPALSPIL
DEG_APCC_DBOX_1
0.5641
p.P1013S
DO232224
PBCA
ICGC
PRPALSPIL
DEG_APCC_DBOX_1
0.1111
p.P1003R
SIDM00363
Acute Myeloid Leukemia
GDSC
PRPALSPIL
DEG_APCC_DBOX_1
0.6401
p.P1003R
SIDM00316
Glioblastoma
GDSC
PRPALSPIL
DEG_APCC_DBOX_1
0.6401
p.P1003R
SIDM00503
Gastric Carcinoma
GDSC
PRPALSPIL
DEG_APCC_DBOX_1
0.6401
p.P1003R
YH-13
central_nervous_system
COSMIC
PRPALSPIL
DEG_APCC_DBOX_1
0.6401
p.P1003R
P31-FUJ
haematopoietic_and_lymphoid_tissue
COSMIC
PRPALSPIL
DEG_APCC_DBOX_1
0.6401
p.P1003R
FU97
stomach
COSMIC
PRPALSPIL
DEG_APCC_DBOX_1
0.6401
p.P1013L
ACH-000665
Lung Cancer
CCLE
PRPALSPIL
DEG_APCC_DBOX_1
0.1111
p.C987F
ACH-001443
Thyroid Cancer
CCLE
PRPALSPIL
DEG_APCC_DBOX_1
0.0556
p.P999R
P31-FUJ
haematopoietic_and_lymphoid_tissue
COSMIC
PRPALSPIL
DEG_APCC_DBOX_1
0.6401
p.P999R
FU97
stomach
COSMIC
PRPALSPIL
DEG_APCC_DBOX_1
0.6401
p.P999R
YH-13
central_nervous_system
COSMIC
PRPALSPIL
DEG_APCC_DBOX_1
0.6401
Drug responses associated with NHSL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRPALSPIL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5SYE7
NHS-like protein 1
DEG_APCC_DBOX_1
997:1005
PRPALSPIL
APC,CDC20,FZR1
0.8764
More...