DegronMD

Uniprot ID: Q5SYE7

Source protein: NHS-like protein 1

Source gene: NHSL1

Class: DEG_SCF_FBW7_1

Location: 178:184

E3 ligase: FBXW7

DEGRON score: 0.9961

ASA_SCORE: 86.3571

COIL: 0.9254

CONS_SCORE: 0.6741

DSS_SCORE: 0.5711

HELIX: 0.0397

FCONS_SCORE: 1.0119

RIG_SCORE: 0.6235

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N180K	DO8264	COAD	ICGC	PKTPASS	DEG_SCF_FBW7_1	0.6918
p.R189L	DO229248	THCA	ICGC	PKTPASS	DEG_SCF_FBW7_1	0.1944
p.R188W	DO43306	UCEC	ICGC	PKTPASS	DEG_SCF_FBW7_1	0.2222
p.R183H	SIDM00569	Osteosarcoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	0.8244
p.R183H	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	0.8244
p.R183H	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	0.8244
p.R183H	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	0.8244
p.R183H	NY	bone	COSMIC	PKTPASS	DEG_SCF_FBW7_1	0.8244
p.R183H	TE-8	oesophagus	COSMIC	PKTPASS	DEG_SCF_FBW7_1	0.8244
p.R183H	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPASS	DEG_SCF_FBW7_1	0.8244
p.R183H	EC-GI-10	oesophagus	COSMIC	PKTPASS	DEG_SCF_FBW7_1	0.8244
p.T191I	SIDM00489	Oral Cavity Carcinoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	0.1389
p.T191I	ACH-002043	Head and Neck Cancer	CCLE	PKTPASS	DEG_SCF_FBW7_1	0.1389
p.T191I	Ca9-22	upper_aerodigestive_tract	COSMIC	PKTPASS	DEG_SCF_FBW7_1	0.1389
p.D182N	SIDM00241	Breast Carcinoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	0.6932
p.D182N	OCUB-M	breast	COSMIC	PKTPASS	DEG_SCF_FBW7_1	0.6932
p.F186V	SIDM00118	Colorectal Carcinoma	GDSC	PKTPASS	DEG_SCF_FBW7_1	0.2778
p.F186V	ACH-001081	Colon/Colorectal Cancer	CCLE	PKTPASS	DEG_SCF_FBW7_1	0.2778
p.F186V	HCC2998	large_intestine	COSMIC	PKTPASS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SYE7	NHS-like protein 1	DEG_SCF_FBW7_1	178:184	PKTPASS	FBXW7	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons