DegronMD

Uniprot ID: Q5SYE7

Source protein: NHS-like protein 1

Source gene: NHSL1

Class: DEG_SCF_TRCP1_1

Location: 618:623

E3 ligase: BTRC

DEGRON score: 0.8252

ASA_SCORE: 67.4

COIL: 0.901

CONS_SCORE: 0.4204

DSS_SCORE: 0.3289

HELIX: 0.042

FCONS_SCORE: 0.8865

RIG_SCORE: 0.6059

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D609N	TCGA-AP-A1DV	UCEC	TCGA	DSGHGS	DEG_SCF_TRCP1_1	0.0833
p.D609N	DO43186	UCEC	ICGC	DSGHGS	DEG_SCF_TRCP1_1	0.0833
p.A613S	TCGA-F4-6570	COAD	TCGA	DSGHGS	DEG_SCF_TRCP1_1	0.1944
p.A613S	DO10443	COAD	ICGC	DSGHGS	DEG_SCF_TRCP1_1	0.1944
p.V615A	SIDM01307	Colorectal Carcinoma	GDSC	DSGHGS	DEG_SCF_TRCP1_1	0.25
p.T617A	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGHGS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SYE7	NHS-like protein 1	DEG_SCF_TRCP1_1	618:623	DSGHGS	BTRC	0.8252	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons