DegronMD - O14647(CHD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K1423N	TCGA-20-1682	OV	TCGA	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation substituting flanking lysine	0.1944
p.K1423N	DO29096	OV	ICGC	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation substituting flanking lysine	0.1944
p.K1424E	TCGA-20-1682	OV	TCGA	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation substituting flanking lysine	0.2222
p.K1424E	DO29096	OV	ICGC	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation substituting flanking lysine	0.2222
p.S1441F	TCGA-A5-A0G2	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation blocking phosphorylation signal	0.6389
p.S1441F	DO41235	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation blocking phosphorylation signal	0.6389
p.K1348N	TCGA-AA-A022	COAD	TCGA	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation altering degron motif	0.6918
p.K1348N	DO10647	COAD	ICGC	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation altering degron motif	0.6918
p.R1440Q	TCGA-AG-A002	READ	TCGA	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation rewiring degron network	0.2222
p.R1440Q	TCGA-BS-A0UF	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation rewiring degron network	0.2222
p.R1440Q	DO41488	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation rewiring degron network	0.2222
p.G1360E	TCGA-AX-A05Z	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.G1360E	TCGA-DF-A2KU	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.G1360E	DO40884	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.G1360E	DO223286	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.S37L	TCGA-AX-A060	UCEC	TCGA	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.7667
p.D1431Y	TCGA-DK-A2HX	BLCA	TCGA	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation rewiring degron network	0.3056
p.D1431Y	DO473	BLCA	ICGC	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation rewiring degron network	0.3056
p.S23L	TCGA-YC-A89H	BLCA	TCGA	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation rewiring degron network	0.0833
p.S36L	DO51948	BLCA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.7667
p.R1345Q	DO227549	COCA	ICGC	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2778
p.D29N	DO234205	ESAD	ICGC	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation rewiring degron network	0.25
p.D29N	DO234285	ESAD	ICGC	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation rewiring degron network	0.25
p.D29N	DO228941	LICA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation rewiring degron network	0.25
p.S1438L	DO48314	ESCA	ICGC	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation rewiring degron network	0.2778
p.S24T	DO233841	GACA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation rewiring degron network	0.1111
p.S36A	DO233917	GACA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.7588
p.R1354S	DO229022	LICA	ICGC	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.25
p.G1443V	DO229025	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation rewiring degron network	0.1389
p.S1441Y	SIDM00082	Melanoma	GDSC	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation blocking phosphorylation signal	0.6389
p.S1441Y	ACH-001190	Skin Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation blocking phosphorylation signal	0.6389
p.S1441Y	SK-MEL-2	skin	COSMIC	AKSSS	DEG_SPOP_SBC_1	1432:1436	Mutation blocking phosphorylation signal	0.6389
p.K1356I	SIDM00293	Small Cell Lung Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation substituting flanking lysine	0.3056
p.K1356I	ACH-002052	Lung Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation substituting flanking lysine	0.3056
p.K1356I	LU-139	lung	COSMIC	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation substituting flanking lysine	0.3056
p.P1353L	SIDM00966	Ovarian Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2778
p.P1353L	OVCA433	ovary	COSMIC	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2778
p.G1360R	SIDM00346	Chronic Myelogenous Leukemia	GDSC	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.G1360R	ACH-000301	Leukemia	CCLE	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.G1360R	LAMA-84	haematopoietic and lymphoid tissue	COSMIC	KKENK	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.Q36E	ACH-000520	Ovarian Cancer	CCLE	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.5633
p.G36E	K2	skin	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.7199
p.F27V	L-1236	haematopoietic and lymphoid tissue	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation rewiring degron network	0.1944
p.L24I	Capan-2	pancreas	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation rewiring degron network	0.1111
p.G36R	K2	skin	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	32:37	Mutation altering degron motif	0.7568

Kaplan plot for CHD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHD2

UniProt ID: O14647

Entrez ID: 1106

Protein name: Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.12) (ATP-dependent helicase CHD2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHD2 in