DegronMD

Uniprot ID: O14647

Source protein: Chromodomain-helicase-DNA-binding protein 2

Source gene: CHD2

Class: DEG_SCF_TRCP1_1

Location: 32:37

E3 ligase: BTRC

DEGRON score: 0.9609

ASA_SCORE: 90.1833

COIL: 0.922

CONS_SCORE: 0.2687

DSS_SCORE: 0.8743

HELIX: 0.0527

FCONS_SCORE: 1.119

RIG_SCORE: 0.4288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S37L	TCGA-AX-A060	UCEC	TCGA	DSGSQS	DEG_SCF_TRCP1_1	0.7667
p.S23L	TCGA-YC-A89H	BLCA	TCGA	DSGSQS	DEG_SCF_TRCP1_1	0.0833
p.S36L	DO51948	BLCA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.7667
p.D29N	DO234205	ESAD	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.25
p.D29N	DO234285	ESAD	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.25
p.D29N	DO228941	LICA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.25
p.S24T	DO233841	GACA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.1111
p.S36A	DO233917	GACA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.7588
p.Q36E	ACH-000520	Ovarian Cancer	CCLE	DSGSQS	DEG_SCF_TRCP1_1	0.5633
p.G36E	K2	skin	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	0.7199
p.F27V	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	0.1944
p.L24I	Capan-2	pancreas	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	0.1111
p.G36R	K2	skin	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_SCF_TRCP1_1	32:37	DSGSQS	BTRC	0.9609	More...
Q76N89	E3 ubiquitin-protein ligase HECW1	DEG_SCF_TRCP1_1	900:905	DSGSQS	BTRC	0.9594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons