DegronMD

Uniprot ID: Q76N89

Source protein: E3 ubiquitin-protein ligase HECW1

Source gene: HECW1

Class: DEG_SCF_TRCP1_1

Location: 900:905

E3 ligase: BTRC

DEGRON score: 0.9594

ASA_SCORE: 81.8

COIL: 0.8602

CONS_SCORE: 0.3893

DSS_SCORE: 0.7678

HELIX: 0.1185

FCONS_SCORE: 1.0345

RIG_SCORE: 0.5842

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P910S	TCGA-3N-A9WB	SKCM	TCGA	DSGSQS	DEG_SCF_TRCP1_1	0.1944
p.P910S	TCGA-ER-A198	SKCM	TCGA	DSGSQS	DEG_SCF_TRCP1_1	0.1944
p.R890Q	TCGA-3N-A9WC	SKCM	TCGA	DSGSQS	DEG_SCF_TRCP1_1	0.0556
p.T894A	TCGA-55-6969	LUAD	TCGA	DSGSQS	DEG_SCF_TRCP1_1	0.1667
p.T894A	SIDM01090	Colorectal Carcinoma	GDSC	DSGSQS	DEG_SCF_TRCP1_1	0.1667
p.T894A	RKO	large_intestine	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	0.1667
p.R890G	TCGA-56-8083	LUSC	TCGA	DSGSQS	DEG_SCF_TRCP1_1	0.0556
p.A893E	TCGA-86-8358	LUAD	TCGA	DSGSQS	DEG_SCF_TRCP1_1	0.1389
p.G912A	TCGA-CM-6168	COAD	TCGA	DSGSQS	DEG_SCF_TRCP1_1	0.1389
p.A893G	TCGA-FJ-A3ZE	BLCA	TCGA	DSGSQS	DEG_SCF_TRCP1_1	0.1389
p.G915R	TCGA-VQ-A91D	STAD	TCGA	DSGSQS	DEG_SCF_TRCP1_1	0.0556
p.S905Y	DO1285	BRCA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.712
p.Q893R	DO222817	BTCA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.1389
p.S905F	DO49985	CESC	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.7982
p.Q910E	DO218922	LUAD	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.1944
p.G902R	DO26752	LUSC	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.7568
p.E890K	DO34096	PACA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.0556
p.L896V	DO36556	READ	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.2222
p.N908K	DO37782	SKCM	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.25
p.S891F	DO51271	SKCM	ICGC	DSGSQS	DEG_SCF_TRCP1_1	0.0833
p.D900N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGSQS	DEG_SCF_TRCP1_1	0.6932
p.D900N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	0.6932
p.G913A	SIDM00892	Breast Carcinoma	GDSC	DSGSQS	DEG_SCF_TRCP1_1	0.1111
p.G913A	BT-483	breast	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	0.1111
p.E907K	SIDM00943	Pancreatic Carcinoma	GDSC	DSGSQS	DEG_SCF_TRCP1_1	0.2778
p.E907K	Capan-2	pancreas	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	0.2778
p.E901Q	ACH-000647	Esophageal Cancer	CCLE	DSGSQS	DEG_SCF_TRCP1_1	0.6744
p.E901Q	TE-1	oesophagus	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	0.6744
p.L898I	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGSQS	DEG_SCF_TRCP1_1	0.2778
p.S901C	JHH-7	liver	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_SCF_TRCP1_1	32:37	DSGSQS	BTRC	0.9609	More...
Q76N89	E3 ubiquitin-protein ligase HECW1	DEG_SCF_TRCP1_1	900:905	DSGSQS	BTRC	0.9594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSQS

Degron related mutations and impact score

Drug responses associated with HECW1 mutations

All proteins holding degron of DSGSQS