DegronMD - Q76N89(HECW1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P910S	TCGA-3N-A9WB	SKCM	TCGA	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.1944
p.P910S	TCGA-ER-A198	SKCM	TCGA	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.1944
p.R890Q	TCGA-3N-A9WC	SKCM	TCGA	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.0556
p.T894A	TCGA-55-6969	LUAD	TCGA	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.1667
p.T894A	SIDM01090	Colorectal Carcinoma	GDSC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.1667
p.T894A	RKO	large intestine	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.1667
p.E1178K	TCGA-55-A4DF	LUAD	TCGA	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation altering degron motif	0.7022
p.R890G	TCGA-56-8083	LUSC	TCGA	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.0556
p.A1167V	TCGA-5M-AAT5	COAD	TCGA	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.A1167V	TCGA-DK-A6AW	BLCA	TCGA	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.A1167V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.A1167V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.A1167V	SIDM00217	Colorectal Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.A1167V	SNU-1040	large intestine	COSMIC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.A1167V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.D1166N	TCGA-63-A5MI	LUSC	TCGA	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1389
p.A893E	TCGA-86-8358	LUAD	TCGA	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.1389
p.L1163M	TCGA-BS-A0UJ	UCEC	TCGA	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.0556
p.G912A	TCGA-CM-6168	COAD	TCGA	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.1389
p.E1177K	TCGA-DK-A1AC	BLCA	TCGA	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation altering degron motif	0.591
p.A893G	TCGA-FJ-A3ZE	BLCA	TCGA	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.1389
p.G915R	TCGA-VQ-A91D	STAD	TCGA	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.0556
p.S905Y	DO1285	BRCA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation altering degron motif	0.712
p.Q893R	DO222817	BTCA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.1389
p.S905F	DO49985	CESC	ICGC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation altering degron motif	0.7982
p.S1163C	DO222734	ESCA	ICGC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.0556
p.A1185P	DO233732	GACA	ICGC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1389
p.S1187C	DO52079	HNSC	ICGC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.0833
p.Q910E	DO218922	LUAD	ICGC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.1944
p.R1184T	DO45332	LUAD	ICGC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.G902R	DO26752	LUSC	ICGC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation altering degron motif	0.7568
p.E890K	DO34096	PACA	ICGC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.0556
p.L896V	DO36556	READ	ICGC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.2222
p.N908K	DO37782	SKCM	ICGC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.25
p.S891F	DO51271	SKCM	ICGC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.0833
p.V1184I	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM00001	Other Blood Cancers	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM01198	Burkitt's Lymphoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM00473	Oral Cavity Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM00831	Head and Neck Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM00695	Melanoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM00139	Mesothelioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM01087	Melanoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM00122	Breast Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM01044	Other Solid Cancers	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM01114	Non-Cancerous	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM00532	Glioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM01246	Ewing's Sarcoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM00224	Mesothelioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM00115	Head and Neck Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184I	SIDM00634	Ewing's Sarcoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM00001	Other Blood Cancers	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM01198	Burkitt's Lymphoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM00473	Oral Cavity Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM00831	Head and Neck Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM00695	Melanoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM00139	Mesothelioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM01087	Melanoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM00122	Breast Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM01044	Other Solid Cancers	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM01114	Non-Cancerous	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM00532	Glioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM01246	Ewing's Sarcoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM00224	Mesothelioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM00115	Head and Neck Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.V1184A	SIDM00634	Ewing's Sarcoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.1667
p.L1172V	SIDM00222	Mesothelioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.3056
p.L1172V	ACH-000319	Lung Cancer	CCLE	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.3056
p.L1172V	MPP-89	pleura	COSMIC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.3056
p.D900N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation altering degron motif	0.6932
p.D900N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation altering degron motif	0.6932
p.G913A	SIDM00892	Breast Carcinoma	GDSC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.1111
p.G913A	BT-483	breast	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.1111
p.E907K	SIDM00943	Pancreatic Carcinoma	GDSC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.2778
p.E907K	Capan-2	pancreas	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.2778
p.E901Q	ACH-000647	Esophageal Cancer	CCLE	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation altering degron motif	0.6744
p.E901Q	TE-1	oesophagus	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation altering degron motif	0.6744
p.Q1179H	ACH-000678	Gastric Cancer	CCLE	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.3056
p.Q1179H	MKN7	stomach	COSMIC	LSLFEE	LIG_APCC_ABBA_1	1173:1178	Mutation rewiring degron network	0.3056
p.L898I	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation rewiring degron network	0.2778
p.S901C	JHH-7	liver	COSMIC	DSGSQS	DEG_SCF_TRCP1_1	900:905	Mutation altering degron motif	0.7541

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HECW1

UniProt ID: Q76N89

Entrez ID: 23072

Protein name: E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HECW1 in