DegronMD

Uniprot ID: Q76N89

Source protein: E3 ubiquitin-protein ligase HECW1

Source gene: HECW1

Class: LIG_APCC_ABBA_1

Location: 1173:1178

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5841

ASA_SCORE: 63.4333

COIL: 0.4352

CONS_SCORE: 0.523

DSS_SCORE: 0.0191

HELIX: 0.5027

FCONS_SCORE: 1.3766

RIG_SCORE: 0.9413

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1178K	TCGA-55-A4DF	LUAD	TCGA	LSLFEE	LIG_APCC_ABBA_1	0.7022
p.A1167V	TCGA-5M-AAT5	COAD	TCGA	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.A1167V	TCGA-DK-A6AW	BLCA	TCGA	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.A1167V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.A1167V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.A1167V	SIDM00217	Colorectal Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.A1167V	SNU-1040	large_intestine	COSMIC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.A1167V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.D1166N	TCGA-63-A5MI	LUSC	TCGA	LSLFEE	LIG_APCC_ABBA_1	0.1389
p.L1163M	TCGA-BS-A0UJ	UCEC	TCGA	LSLFEE	LIG_APCC_ABBA_1	0.0556
p.E1177K	TCGA-DK-A1AC	BLCA	TCGA	LSLFEE	LIG_APCC_ABBA_1	0.591
p.S1163C	DO222734	ESCA	ICGC	LSLFEE	LIG_APCC_ABBA_1	0.0556
p.A1185P	DO233732	GACA	ICGC	LSLFEE	LIG_APCC_ABBA_1	0.1389
p.S1187C	DO52079	HNSC	ICGC	LSLFEE	LIG_APCC_ABBA_1	0.0833
p.R1184T	DO45332	LUAD	ICGC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM00001	Other Blood Cancers	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM01198	Burkitt's Lymphoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM00473	Oral Cavity Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM00831	Head and Neck Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM00695	Melanoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM00139	Mesothelioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM01087	Melanoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM00122	Breast Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM01044	Other Solid Cancers	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM01114	Non-Cancerous	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM00532	Glioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM01246	Ewing's Sarcoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM00224	Mesothelioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM00115	Head and Neck Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184I	SIDM00634	Ewing's Sarcoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM00001	Other Blood Cancers	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM01198	Burkitt's Lymphoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM00473	Oral Cavity Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM00831	Head and Neck Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM00695	Melanoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM00139	Mesothelioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM01087	Melanoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM00122	Breast Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM01044	Other Solid Cancers	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM01114	Non-Cancerous	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM00532	Glioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM01246	Ewing's Sarcoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM00224	Mesothelioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM00115	Head and Neck Carcinoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.V1184A	SIDM00634	Ewing's Sarcoma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.1667
p.L1172V	SIDM00222	Mesothelioma	GDSC	LSLFEE	LIG_APCC_ABBA_1	0.3056
p.L1172V	ACH-000319	Lung Cancer	CCLE	LSLFEE	LIG_APCC_ABBA_1	0.3056
p.L1172V	MPP-89	pleura	COSMIC	LSLFEE	LIG_APCC_ABBA_1	0.3056
p.Q1179H	ACH-000678	Gastric Cancer	CCLE	LSLFEE	LIG_APCC_ABBA_1	0.3056
p.Q1179H	MKN7	stomach	COSMIC	LSLFEE	LIG_APCC_ABBA_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSLFEE

Degron related mutations and impact score

Drug responses associated with HECW1 mutations

All proteins holding degron of LSLFEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76N89	E3 ubiquitin-protein ligase HECW1	LIG_APCC_ABBA_1	1173:1178	LSLFEE	APC,CDC20,FZR1	0.5841	More...