DegronMD

Uniprot ID: O14647

Source protein: Chromodomain-helicase-DNA-binding protein 2

Source gene: CHD2

Class: DEG_APCC_KENBOX_2

Location: 1347:1351

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6193

ASA_SCORE: 133.06

COIL: 0.7662

CONS_SCORE: 0.2263

DSS_SCORE: 0.6532

HELIX: 0.2138

FCONS_SCORE: 0.9218

RIG_SCORE: 0.6917

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1348N	TCGA-AA-A022	COAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.6918
p.K1348N	DO10647	COAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.6918
p.G1360E	TCGA-AX-A05Z	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0833
p.G1360E	TCGA-DF-A2KU	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0833
p.G1360E	DO40884	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0833
p.G1360E	DO223286	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0833
p.R1345Q	DO227549	COCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R1354S	DO229022	LICA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.25
p.K1356I	SIDM00293	Small Cell Lung Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.3056
p.K1356I	ACH-002052	Lung Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.3056
p.K1356I	LU-139	lung	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.3056
p.P1353L	SIDM00966	Ovarian Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.P1353L	OVCA433	ovary	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.G1360R	SIDM00346	Chronic Myelogenous Leukemia	GDSC	KKENK	DEG_APCC_KENBOX_2	0.0833
p.G1360R	ACH-000301	Leukemia	CCLE	KKENK	DEG_APCC_KENBOX_2	0.0833
p.G1360R	LAMA-84	haematopoietic_and_lymphoid_tissue	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_APCC_KENBOX_2	1347:1351	KKENK	APC,CDC20,FZR1	0.6193	More...
P09629	Homeobox protein Hox-B7	DEG_APCC_KENBOX_2	193:197	KKENK	APC,CDC20,FZR1	0.5932	More...
P78411	Iroquois-class homeodomain protein IRX-5	DEG_APCC_KENBOX_2	172:176	KKENK	APC,CDC20,FZR1	0.8587	More...
P78412	Iroquois-class homeodomain protein IRX-6	DEG_APCC_KENBOX_2	205:209	KKENK	APC,CDC20,FZR1	0.8695	More...
P78413	Iroquois-class homeodomain protein IRX-4	DEG_APCC_KENBOX_2	201:205	KKENK	APC,CDC20,FZR1	0.9359	More...
Q9H0A6	RING finger protein 32	DEG_APCC_KENBOX_2	46:50	KKENK	APC,CDC20,FZR1	0.9703	More...
Q9NQS3	Nectin-3	DEG_APCC_KENBOX_2	471:475	KKENK	APC,CDC20,FZR1	0.5241	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_APCC_KENBOX_2	914:918	KKENK	APC,CDC20,FZR1	0.8734	More...
P31267	Homeobox protein Hox-A6	DEG_APCC_KENBOX_2	211:215	KKENK	APC,CDC20,FZR1	0.8614	More...
P78414	Iroquois-class homeodomain protein IRX-1	DEG_APCC_KENBOX_2	186:190	KKENK	APC,CDC20,FZR1	0.8603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons