DegronMD

Uniprot ID: P31267

Source protein: Homeobox protein Hox-A6

Source gene: HOXA6

Class: DEG_APCC_KENBOX_2

Location: 211:215

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8614

ASA_SCORE: 118.38

COIL: 0.6162

CONS_SCORE: 0.8342

DSS_SCORE: 0.4558

HELIX: 0.3472

FCONS_SCORE: 0.9925

RIG_SCORE: 0.7981

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P222R	TCGA-62-8399	LUAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1389
p.P222R	DO24606	LUAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1389
p.R206H	TCGA-AX-A3FT	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R206H	DO40801	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R207H	TCGA-BR-4184	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R207H	TCGA-BR-6566	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R207H	DO227709	COCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R207H	DO38328	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R207H	DO38217	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.P222H	TCGA-D1-A17Q	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1389
p.P222H	DO41903	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1389
p.G224R	TCGA-FI-A2D0	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0833
p.G224R	DO43891	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0833
p.R206C	TCGA-VQ-A8P2	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R206C	DO51761	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.K212N	DO227976	COCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.6918
p.R206S	DO229031	LICA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.T220M	DO231174	LUSC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.T220M	SIDM00140	Melanoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.T220M	ACH-000968	Skin Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1944
p.T220M	COLO-792	skin	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.E213K	DO222731	MELA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_APCC_KENBOX_2	1347:1351	KKENK	APC,CDC20,FZR1	0.6193	More...
P09629	Homeobox protein Hox-B7	DEG_APCC_KENBOX_2	193:197	KKENK	APC,CDC20,FZR1	0.5932	More...
P78411	Iroquois-class homeodomain protein IRX-5	DEG_APCC_KENBOX_2	172:176	KKENK	APC,CDC20,FZR1	0.8587	More...
P78412	Iroquois-class homeodomain protein IRX-6	DEG_APCC_KENBOX_2	205:209	KKENK	APC,CDC20,FZR1	0.8695	More...
P78413	Iroquois-class homeodomain protein IRX-4	DEG_APCC_KENBOX_2	201:205	KKENK	APC,CDC20,FZR1	0.9359	More...
Q9H0A6	RING finger protein 32	DEG_APCC_KENBOX_2	46:50	KKENK	APC,CDC20,FZR1	0.9703	More...
Q9NQS3	Nectin-3	DEG_APCC_KENBOX_2	471:475	KKENK	APC,CDC20,FZR1	0.5241	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_APCC_KENBOX_2	914:918	KKENK	APC,CDC20,FZR1	0.8734	More...
P31267	Homeobox protein Hox-A6	DEG_APCC_KENBOX_2	211:215	KKENK	APC,CDC20,FZR1	0.8614	More...
P78414	Iroquois-class homeodomain protein IRX-1	DEG_APCC_KENBOX_2	186:190	KKENK	APC,CDC20,FZR1	0.8603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons