DegronMD - P78412(IRX6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F197L	TCGA-67-3770	LUAD	TCGA	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.1111
p.F197L	DO23932	LUAD	ICGC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.1111
p.R203C	TCGA-A5-A0G2	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2778
p.R203C	TCGA-AX-A1CE	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2778
p.R203C	DO42280	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2778
p.R203C	DO41235	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2778
p.R203C	SIDM01609	Endometrial Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2778
p.R203C	ACH-000972	Endometrial/Uterine Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2778
p.A213V	TCGA-B5-A1MR	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2222
p.A213V	DO41758	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2222
p.A213V	SIDM00359	Colorectal Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2222
p.A213V	ACH-000565	Colon/Colorectal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2222
p.A213V	RCM-1	large intestine	COSMIC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2222
p.R201C	TCGA-BG-A0MS	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2222
p.R201C	DO41855	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2222
p.A200E	TCGA-T2-A6WZ	HNSC	TCGA	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.1944
p.A200E	DO219067	HNSC	ICGC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.1944
p.R203H	DO1241	BRCA	ICGC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2778
p.L204F	DO220862	MELA	ICGC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.3056
p.K215Q	DO229224	THCA	ICGC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation substituting flanking lysine	0.2778
p.K215Q	SIDM00572	Gastric Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation substituting flanking lysine	0.2778
p.K215Q	SIDM00057	Neuroblastoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation substituting flanking lysine	0.2778
p.K215Q	SIDM00552	Rhabdomyosarcoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation substituting flanking lysine	0.2778
p.K215Q	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation substituting flanking lysine	0.2778
p.K215Q	SIDM00060	Ovarian Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation substituting flanking lysine	0.2778
p.K215Q	SIDM00591	Oral Cavity Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation substituting flanking lysine	0.2778
p.K215Q	SIDM01728	Endometrial Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation substituting flanking lysine	0.2778
p.K215Q	SIDM01449	Pancreatic Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation substituting flanking lysine	0.2778
p.K215Q	SIDM01470	Acute Myeloid Leukemia	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation substituting flanking lysine	0.2778
p.K215Q	SIDM01588	Endometrial Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation substituting flanking lysine	0.2778
p.K215Q	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation substituting flanking lysine	0.2778
p.G219W	SIDM00993	Plasma Cell Myeloma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.0556
p.G219W	ACH-000838	Myeloma	CCLE	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.0556
p.G219W	AMO-1	haematopoietic and lymphoid tissue	COSMIC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.0556
p.R201H	SIDM00333	Endometrial Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2222
p.R201H	ACH-000988	Endometrial/Uterine Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2222
p.R201H	MFE-319	endometrium	COSMIC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.2222
p.R202W	SIDM01101	Neuroblastoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.25
p.R202W	ACH-000260	Neuroblastoma	CCLE	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.25
p.R202W	SK-N-AS	autonomic ganglia	COSMIC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.25
p.K205T	SIDM00214	Colorectal Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation altering degron motif	0.6195
p.K205T	ACH-000955	Colon/Colorectal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation altering degron motif	0.6195
p.K205T	SNU-407	large intestine	COSMIC	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation altering degron motif	0.6195
p.R202L	ACH-000901	Lung Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	205:209	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRX6

UniProt ID: P78412

Entrez ID: 79190

Protein name: Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRX6 in