DegronMD

Uniprot ID: P78412

Source protein: Iroquois-class homeodomain protein IRX-6

Source gene: IRX6

Class: DEG_APCC_KENBOX_2

Location: 205:209

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8695

ASA_SCORE: 119.26

COIL: 0.5372

CONS_SCORE: 0.8252

DSS_SCORE: 0.487

HELIX: 0.4684

FCONS_SCORE: 1.0575

RIG_SCORE: 0.762

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F197L	TCGA-67-3770	LUAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1111
p.F197L	DO23932	LUAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1111
p.R203C	TCGA-A5-A0G2	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R203C	TCGA-AX-A1CE	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R203C	DO42280	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R203C	DO41235	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R203C	SIDM01609	Endometrial Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R203C	ACH-000972	Endometrial/Uterine Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.2778
p.A213V	TCGA-B5-A1MR	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2222
p.A213V	DO41758	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.A213V	SIDM00359	Colorectal Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.A213V	ACH-000565	Colon/Colorectal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.2222
p.A213V	RCM-1	large_intestine	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R201C	TCGA-BG-A0MS	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R201C	DO41855	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.A200E	TCGA-T2-A6WZ	HNSC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A200E	DO219067	HNSC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R203H	DO1241	BRCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.L204F	DO220862	MELA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.3056
p.K215Q	DO229224	THCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.K215Q	SIDM00572	Gastric Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.K215Q	SIDM00057	Neuroblastoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.K215Q	SIDM00552	Rhabdomyosarcoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.K215Q	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.K215Q	SIDM00060	Ovarian Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.K215Q	SIDM00591	Oral Cavity Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.K215Q	SIDM01728	Endometrial Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.K215Q	SIDM01449	Pancreatic Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.K215Q	SIDM01470	Acute Myeloid Leukemia	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.K215Q	SIDM01588	Endometrial Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.K215Q	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.G219W	SIDM00993	Plasma Cell Myeloma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.G219W	ACH-000838	Myeloma	CCLE	KKENK	DEG_APCC_KENBOX_2	0.0556
p.G219W	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.R201H	SIDM00333	Endometrial Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R201H	ACH-000988	Endometrial/Uterine Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R201H	MFE-319	endometrium	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R202W	SIDM01101	Neuroblastoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.25
p.R202W	ACH-000260	Neuroblastoma	CCLE	KKENK	DEG_APCC_KENBOX_2	0.25
p.R202W	SK-N-AS	autonomic_ganglia	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.25
p.K205T	SIDM00214	Colorectal Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.6195
p.K205T	ACH-000955	Colon/Colorectal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.6195
p.K205T	SNU-407	large_intestine	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.6195
p.R202L	ACH-000901	Lung Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_APCC_KENBOX_2	1347:1351	KKENK	APC,CDC20,FZR1	0.6193	More...
P09629	Homeobox protein Hox-B7	DEG_APCC_KENBOX_2	193:197	KKENK	APC,CDC20,FZR1	0.5932	More...
P78411	Iroquois-class homeodomain protein IRX-5	DEG_APCC_KENBOX_2	172:176	KKENK	APC,CDC20,FZR1	0.8587	More...
P78412	Iroquois-class homeodomain protein IRX-6	DEG_APCC_KENBOX_2	205:209	KKENK	APC,CDC20,FZR1	0.8695	More...
P78413	Iroquois-class homeodomain protein IRX-4	DEG_APCC_KENBOX_2	201:205	KKENK	APC,CDC20,FZR1	0.9359	More...
Q9H0A6	RING finger protein 32	DEG_APCC_KENBOX_2	46:50	KKENK	APC,CDC20,FZR1	0.9703	More...
Q9NQS3	Nectin-3	DEG_APCC_KENBOX_2	471:475	KKENK	APC,CDC20,FZR1	0.5241	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_APCC_KENBOX_2	914:918	KKENK	APC,CDC20,FZR1	0.8734	More...
P31267	Homeobox protein Hox-A6	DEG_APCC_KENBOX_2	211:215	KKENK	APC,CDC20,FZR1	0.8614	More...
P78414	Iroquois-class homeodomain protein IRX-1	DEG_APCC_KENBOX_2	186:190	KKENK	APC,CDC20,FZR1	0.8603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKENK

Degron related mutations and impact score

Drug responses associated with IRX6 mutations

All proteins holding degron of KKENK