DegronMD - P78413(IRX4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P209L	TCGA-2W-A8YY	CESC	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.P209L	DO223732	CESC	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.P209L	DO222794	COCA	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.N212K	TCGA-37-4141	LUSC	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.1389
p.N212K	DO26862	LUSC	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.1389
p.T191S	TCGA-3G-AB0T	THYM	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.0556
p.R197H	TCGA-AA-3815	COAD	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.R197H	TCGA-D1-A103	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.R197H	DO9924	COAD	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.R197H	DO42312	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.R197C	TCGA-BG-A221	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.R197C	DO42384	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.R197C	ACH-000647	Esophageal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.R197C	TE-1	oesophagus	COSMIC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.P209S	TCGA-BR-4184	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.P209S	DO38328	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2222
p.T207K	TCGA-CN-4735	HNSC	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2778
p.T207K	DO14172	HNSC	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2778
p.R211W	TCGA-D1-A0ZS	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.1667
p.R211W	TCGA-QS-A8F1	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.1667
p.R211W	DO219783	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.1667
p.R211W	DO43626	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.1667
p.R211W	ACH-000999	Colon/Colorectal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.1667
p.R211W	SNU-1040	large intestine	COSMIC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.1667
p.T207M	TCGA-DM-A1D6	COAD	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2778
p.T207M	TCGA-DM-A1HB	COAD	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2778
p.T207M	DO10686	COAD	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2778
p.T207M	DO233760	GACA	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2778
p.R198W	TCGA-FU-A3HZ	CESC	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.25
p.R198W	DO6308	CESC	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.25
p.R211Q	TCGA-FW-A3R5	SKCM	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.1667
p.R211Q	DO37406	SKCM	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.1667
p.A215T	TCGA-HU-A4GF	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.0556
p.A215T	DO47885	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.0556
p.A215T	ACH-001002	Skin Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.0556
p.A215T	451Lu	skin	COSMIC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.0556
p.K201M	DO48207	ESCA	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation altering degron motif	0.6951
p.R199H	DO233797	GACA	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.2778
p.W208L	DO229056	LICA	ICGC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.25
p.T208P	SIDM02068	Esophageal Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.25
p.R191P	SIDM00461	Acute Myeloid Leukemia	GDSC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.0556
p.R191P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.0556
p.P194L	SIDM01397	Melanoma	GDSC	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation rewiring degron network	0.1389
p.E203Q	ACH-001853	Bile Duct Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	201:205	Mutation altering degron motif	0.6744

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRX4

UniProt ID: P78413

Entrez ID: 50805

Protein name: Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRX4 in