DegronMD

Uniprot ID: P78413

Source protein: Iroquois-class homeodomain protein IRX-4

Source gene: IRX4

Class: DEG_APCC_KENBOX_2

Location: 201:205

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9359

ASA_SCORE: 120

COIL: 0.579

CONS_SCORE: 0.7636

DSS_SCORE: 0.4783

HELIX: 0.4216

FCONS_SCORE: 1.048

RIG_SCORE: 0.7426

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P209L	TCGA-2W-A8YY	CESC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2222
p.P209L	DO223732	CESC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.P209L	DO222794	COCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.N212K	TCGA-37-4141	LUSC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1389
p.N212K	DO26862	LUSC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1389
p.T191S	TCGA-3G-AB0T	THYM	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0556
p.R197H	TCGA-AA-3815	COAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R197H	TCGA-D1-A103	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R197H	DO9924	COAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R197H	DO42312	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R197C	TCGA-BG-A221	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R197C	DO42384	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R197C	ACH-000647	Esophageal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R197C	TE-1	oesophagus	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.P209S	TCGA-BR-4184	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2222
p.P209S	DO38328	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.T207K	TCGA-CN-4735	HNSC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2778
p.T207K	DO14172	HNSC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R211W	TCGA-D1-A0ZS	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R211W	TCGA-QS-A8F1	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R211W	DO219783	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R211W	DO43626	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R211W	ACH-000999	Colon/Colorectal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R211W	SNU-1040	large_intestine	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.1667
p.T207M	TCGA-DM-A1D6	COAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2778
p.T207M	TCGA-DM-A1HB	COAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2778
p.T207M	DO10686	COAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.T207M	DO233760	GACA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R198W	TCGA-FU-A3HZ	CESC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.25
p.R198W	DO6308	CESC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.25
p.R211Q	TCGA-FW-A3R5	SKCM	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R211Q	DO37406	SKCM	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1667
p.A215T	TCGA-HU-A4GF	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0556
p.A215T	DO47885	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.A215T	ACH-001002	Skin Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.0556
p.A215T	451Lu	skin	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.K201M	DO48207	ESCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.6951
p.R199H	DO233797	GACA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.W208L	DO229056	LICA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.25
p.T208P	SIDM02068	Esophageal Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.25
p.R191P	SIDM00461	Acute Myeloid Leukemia	GDSC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.R191P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.P194L	SIDM01397	Melanoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1389
p.E203Q	ACH-001853	Bile Duct Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_APCC_KENBOX_2	1347:1351	KKENK	APC,CDC20,FZR1	0.6193	More...
P09629	Homeobox protein Hox-B7	DEG_APCC_KENBOX_2	193:197	KKENK	APC,CDC20,FZR1	0.5932	More...
P78411	Iroquois-class homeodomain protein IRX-5	DEG_APCC_KENBOX_2	172:176	KKENK	APC,CDC20,FZR1	0.8587	More...
P78412	Iroquois-class homeodomain protein IRX-6	DEG_APCC_KENBOX_2	205:209	KKENK	APC,CDC20,FZR1	0.8695	More...
P78413	Iroquois-class homeodomain protein IRX-4	DEG_APCC_KENBOX_2	201:205	KKENK	APC,CDC20,FZR1	0.9359	More...
Q9H0A6	RING finger protein 32	DEG_APCC_KENBOX_2	46:50	KKENK	APC,CDC20,FZR1	0.9703	More...
Q9NQS3	Nectin-3	DEG_APCC_KENBOX_2	471:475	KKENK	APC,CDC20,FZR1	0.5241	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_APCC_KENBOX_2	914:918	KKENK	APC,CDC20,FZR1	0.8734	More...
P31267	Homeobox protein Hox-A6	DEG_APCC_KENBOX_2	211:215	KKENK	APC,CDC20,FZR1	0.8614	More...
P78414	Iroquois-class homeodomain protein IRX-1	DEG_APCC_KENBOX_2	186:190	KKENK	APC,CDC20,FZR1	0.8603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKENK

Degron related mutations and impact score

Drug responses associated with IRX4 mutations

All proteins holding degron of KKENK