DegronMD - P31267(HOXA6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P222R	TCGA-62-8399	LUAD	TCGA	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1389
p.P222R	DO24606	LUAD	ICGC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1389
p.E108K	TCGA-AA-A00N	COAD	TCGA	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1944
p.E108K	DO9876	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1944
p.E108K	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1944
p.E108K	ACH-000893	Lung Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1944
p.E108K	NCI-H1651	lung	COSMIC	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1944
p.R206H	TCGA-AX-A3FT	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1944
p.R206H	DO40801	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1944
p.R207H	TCGA-BR-4184	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.2222
p.R207H	TCGA-BR-6566	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.2222
p.R207H	DO227709	COCA	ICGC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.2222
p.R207H	DO38328	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.2222
p.R207H	DO38217	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.2222
p.L123P	TCGA-BR-8363	STAD	TCGA	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1667
p.L123P	DO47837	STAD	ICGC	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1667
p.P222H	TCGA-D1-A17Q	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1389
p.P222H	DO41903	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1389
p.E126K	TCGA-EE-A181	SKCM	TCGA	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0833
p.E126K	DO37444	SKCM	ICGC	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0833
p.G224R	TCGA-FI-A2D0	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.0833
p.G224R	DO43891	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.0833
p.R206C	TCGA-VQ-A8P2	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1944
p.R206C	DO51761	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1944
p.K212N	DO227976	COCA	ICGC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation altering degron motif	0.6918
p.S116R	DO228952	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation altering degron motif	0.7427
p.L103M	DO228974	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556
p.Q110K	DO228978	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.25
p.R206S	DO229031	LICA	ICGC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1944
p.T220M	DO231174	LUSC	ICGC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1944
p.T220M	SIDM00140	Melanoma	GDSC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1944
p.T220M	ACH-000968	Skin Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1944
p.T220M	COLO-792	skin	COSMIC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation rewiring degron network	0.1944
p.E213K	DO222731	MELA	ICGC	KKENK	DEG_APCC_KENBOX_2	211:215	Mutation altering degron motif	0.7022
p.G127D	SIDM01617	Endometrial Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556
p.G127D	ACH-000994	Endometrial/Uterine Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556
p.G127S	SIDM01617	Endometrial Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556
p.G127S	ACH-000994	Endometrial/Uterine Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.0556

Kaplan plot for HOXA6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXA6

UniProt ID: P31267

Entrez ID: 3203

Protein name: Homeobox protein Hox-A6 (Homeobox protein Hox-1B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOXA6 in