DegronMD

Uniprot ID: Q9NQS3

Source protein: Nectin-3

Source gene: NECTIN3

Class: DEG_APCC_KENBOX_2

Location: 471:475

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5241

ASA_SCORE: 127.14

COIL: 0.876

CONS_SCORE: 0.528

DSS_SCORE: 0.5482

HELIX: 0.0794

FCONS_SCORE: 1.0543

RIG_SCORE: 0.6737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N480S	SIDM00584	Osteosarcoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.N480S	SIDM00560	Gastric Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.N474K	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.6918
p.N474K	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.6918
p.N474K	A549	lung	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_APCC_KENBOX_2	1347:1351	KKENK	APC,CDC20,FZR1	0.6193	More...
P09629	Homeobox protein Hox-B7	DEG_APCC_KENBOX_2	193:197	KKENK	APC,CDC20,FZR1	0.5932	More...
P78411	Iroquois-class homeodomain protein IRX-5	DEG_APCC_KENBOX_2	172:176	KKENK	APC,CDC20,FZR1	0.8587	More...
P78412	Iroquois-class homeodomain protein IRX-6	DEG_APCC_KENBOX_2	205:209	KKENK	APC,CDC20,FZR1	0.8695	More...
P78413	Iroquois-class homeodomain protein IRX-4	DEG_APCC_KENBOX_2	201:205	KKENK	APC,CDC20,FZR1	0.9359	More...
Q9H0A6	RING finger protein 32	DEG_APCC_KENBOX_2	46:50	KKENK	APC,CDC20,FZR1	0.9703	More...
Q9NQS3	Nectin-3	DEG_APCC_KENBOX_2	471:475	KKENK	APC,CDC20,FZR1	0.5241	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_APCC_KENBOX_2	914:918	KKENK	APC,CDC20,FZR1	0.8734	More...
P31267	Homeobox protein Hox-A6	DEG_APCC_KENBOX_2	211:215	KKENK	APC,CDC20,FZR1	0.8614	More...
P78414	Iroquois-class homeodomain protein IRX-1	DEG_APCC_KENBOX_2	186:190	KKENK	APC,CDC20,FZR1	0.8603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons