DegronMD

Uniprot ID: P09629

Source protein: Homeobox protein Hox-B7

Source gene: HOXB7

Class: DEG_APCC_KENBOX_2

Location: 193:197

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5932

ASA_SCORE: 119.42

COIL: 0.6614

CONS_SCORE: 0.7104

DSS_SCORE: 0.5687

HELIX: 0.328

FCONS_SCORE: 1.0275

RIG_SCORE: 0.7194

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K193E	TCGA-12-0778	GBM	TCGA	KKENK	DEG_APCC_KENBOX_2	0.591
p.K193E	DO11411	GBM	ICGC	KKENK	DEG_APCC_KENBOX_2	0.591
p.D207H	TCGA-AC-A23H	BRCA	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0556
p.D207H	DO2401	BRCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.D207G	TCGA-AP-A056	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0556
p.D207G	DO43971	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.P201S	DO222749	MELA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R188W	SIDM02050	Colorectal Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R188W	SIDM01164	Glioma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R188W	ACH-000883	Brain Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R188W	SW1783	central_nervous_system	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R189C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R188Q	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R188Q	ACH-000318	Esophageal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R188Q	TE-10	oesophagus	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_APCC_KENBOX_2	1347:1351	KKENK	APC,CDC20,FZR1	0.6193	More...
P09629	Homeobox protein Hox-B7	DEG_APCC_KENBOX_2	193:197	KKENK	APC,CDC20,FZR1	0.5932	More...
P78411	Iroquois-class homeodomain protein IRX-5	DEG_APCC_KENBOX_2	172:176	KKENK	APC,CDC20,FZR1	0.8587	More...
P78412	Iroquois-class homeodomain protein IRX-6	DEG_APCC_KENBOX_2	205:209	KKENK	APC,CDC20,FZR1	0.8695	More...
P78413	Iroquois-class homeodomain protein IRX-4	DEG_APCC_KENBOX_2	201:205	KKENK	APC,CDC20,FZR1	0.9359	More...
Q9H0A6	RING finger protein 32	DEG_APCC_KENBOX_2	46:50	KKENK	APC,CDC20,FZR1	0.9703	More...
Q9NQS3	Nectin-3	DEG_APCC_KENBOX_2	471:475	KKENK	APC,CDC20,FZR1	0.5241	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_APCC_KENBOX_2	914:918	KKENK	APC,CDC20,FZR1	0.8734	More...
P31267	Homeobox protein Hox-A6	DEG_APCC_KENBOX_2	211:215	KKENK	APC,CDC20,FZR1	0.8614	More...
P78414	Iroquois-class homeodomain protein IRX-1	DEG_APCC_KENBOX_2	186:190	KKENK	APC,CDC20,FZR1	0.8603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons