DegronMD

Uniprot ID: P78411

Source protein: Iroquois-class homeodomain protein IRX-5

Source gene: IRX5

Class: DEG_APCC_KENBOX_2

Location: 172:176

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8587

ASA_SCORE: 125

COIL: 0.6544

CONS_SCORE: 0.5382

DSS_SCORE: 0.4259

HELIX: 0.3518

FCONS_SCORE: 0.9402

RIG_SCORE: 0.7364

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R169W	TCGA-A5-A0G2	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.25
p.R182Q	TCGA-AJ-A3BH	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R182Q	TCGA-AJ-A8CW	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1667
p.T180M	TCGA-AJ-A3EL	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.6667
p.R182W	TCGA-AP-A056	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R182W	TCGA-AP-A0LM	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R170H	TCGA-AX-A2HH	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2778
p.A167T	TCGA-B5-A1MW	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1944
p.E186K	TCGA-BS-A0UV	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0556
p.T178P	TCGA-D3-A8GR	SKCM	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2778
p.E174D	TCGA-EO-A22X	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.6758
p.M177T	TCGA-VS-A8QH	CESC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.3056
p.L182V	DO44049	BLCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R180W	DO465	BLCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.6667
p.R180W	DO42472	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.6667
p.G174D	DO7178	CLLE	ICGC	KKENK	DEG_APCC_KENBOX_2	0.7198
p.A186T	DO8119	COAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.P171A	DO23830	LUAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.3056
p.P171L	DO26608	LUSC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.3056
p.Q167H	DO229259	THCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A167V	SIDM00602	Gastric Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A167V	ACH-000919	Gastric Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A167V	IM-95	stomach	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.P181S	SIDM01175	Other Sarcomas	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.P181S	ACH-002309	Sarcoma	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1944
p.P181S	SW684	soft_tissue	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.T178S	SIDM00282	Colorectal Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.T178S	ACH-000998	Colon/Colorectal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.2778
p.T178S	CW-2	large_intestine	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.S167L	ACH-000725	Breast Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1944
p.S167L	HCC202	breast	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R164C	ACH-000874	Leukemia	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1111
p.R164C	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.1111
p.A168V	ACH-001377	Pancreatic Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_APCC_KENBOX_2	1347:1351	KKENK	APC,CDC20,FZR1	0.6193	More...
P09629	Homeobox protein Hox-B7	DEG_APCC_KENBOX_2	193:197	KKENK	APC,CDC20,FZR1	0.5932	More...
P78411	Iroquois-class homeodomain protein IRX-5	DEG_APCC_KENBOX_2	172:176	KKENK	APC,CDC20,FZR1	0.8587	More...
P78412	Iroquois-class homeodomain protein IRX-6	DEG_APCC_KENBOX_2	205:209	KKENK	APC,CDC20,FZR1	0.8695	More...
P78413	Iroquois-class homeodomain protein IRX-4	DEG_APCC_KENBOX_2	201:205	KKENK	APC,CDC20,FZR1	0.9359	More...
Q9H0A6	RING finger protein 32	DEG_APCC_KENBOX_2	46:50	KKENK	APC,CDC20,FZR1	0.9703	More...
Q9NQS3	Nectin-3	DEG_APCC_KENBOX_2	471:475	KKENK	APC,CDC20,FZR1	0.5241	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_APCC_KENBOX_2	914:918	KKENK	APC,CDC20,FZR1	0.8734	More...
P31267	Homeobox protein Hox-A6	DEG_APCC_KENBOX_2	211:215	KKENK	APC,CDC20,FZR1	0.8614	More...
P78414	Iroquois-class homeodomain protein IRX-1	DEG_APCC_KENBOX_2	186:190	KKENK	APC,CDC20,FZR1	0.8603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKENK

Degron related mutations and impact score

Drug responses associated with IRX5 mutations

All proteins holding degron of KKENK