DegronMD

Uniprot ID: P78414

Source protein: Iroquois-class homeodomain protein IRX-1

Source gene: IRX1

Class: DEG_APCC_KENBOX_2

Location: 186:190

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8603

ASA_SCORE: 123.9

COIL: 0.5564

CONS_SCORE: 0.6551

DSS_SCORE: 0.3858

HELIX: 0.4288

FCONS_SCORE: 1.0004

RIG_SCORE: 0.7852

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D199H	TCGA-17-Z041	LUAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0833
p.Q200K	TCGA-55-A490	LUAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0556
p.Q200K	TCGA-BB-7870	HNSC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0556
p.Q200K	TCGA-FD-A5BZ	BLCA	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0556
p.Q200K	DO44052	BLCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.Q200K	DO14378	HNSC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.Q200K	DO24596	LUAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.R196L	TCGA-78-7220	LUAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R196L	DO24409	LUAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R183Q	TCGA-AP-A0LM	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.25
p.R183Q	DO43306	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.25
p.A195E	TCGA-B0-5084	KIRC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A195E	DO19713	KIRC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R184H	TCGA-B5-A3FA	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R184H	DO52402	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R184H	SIDM00216	Colorectal Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R184H	ACH-000989	Colon/Colorectal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R184H	SNU-175	large_intestine	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.Q200H	TCGA-BA-6869	HNSC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0556
p.Q200H	DO14250	HNSC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.N189K	TCGA-C8-A274	BRCA	TCGA	KKENK	DEG_APCC_KENBOX_2	0.6918
p.N189K	DO5675	BRCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.6918
p.A181V	TCGA-CK-5913	COAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A181V	DO8826	COAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A181V	DO233647	GACA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A181V	DO233941	GACA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R183W	TCGA-D1-A103	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.25
p.R183W	DO42312	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.25
p.W177C	TCGA-D5-5540	COAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0833
p.W177C	DO8738	COAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0833
p.R196C	TCGA-DF-A2KV	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R196C	DO233245	GACA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R196C	DO219771	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R182C	TCGA-EJ-5496	PRAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2222
p.R182C	DO36266	PRAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.E188D	TCGA-F5-6814	READ	TCGA	KKENK	DEG_APCC_KENBOX_2	0.6758
p.E188D	DO36556	READ	ICGC	KKENK	DEG_APCC_KENBOX_2	0.6758
p.A179T	TCGA-FG-6692	LGG	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1389
p.A179T	DO22307	LGG	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1389
p.T176A	TCGA-FP-7829	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0556
p.T176A	DO38308	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.K198N	TCGA-G4-6309	COAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2222
p.K198N	DO7810	COAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2222
p.L185F	TCGA-HU-A4GT	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.3056
p.L185F	DO48020	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.3056
p.R184L	TCGA-L9-A7SV	LUAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.2778
p.R184L	DO49875	LUAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.A181T	TCGA-VS-A8QF	CESC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A181T	DO51629	CESC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A181T	DO233888	GACA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.R196H	DO227984	COCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R196H	ACH-002287	Colon/Colorectal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1667
p.R196H	NCI-H630	large_intestine	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.1667
p.A195T	DO22812	LICA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.K186N	DO33091	PACA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.5806
p.A195V	SIDM00781	Colorectal Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A195V	SIDM00780	Colorectal Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A195V	ACH-000967	Colon/Colorectal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A195V	ACH-001199	Colon/Colorectal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1944
p.A195V	SNU-C2B	large_intestine	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.S197N	SIDM00239	Kidney Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1389
p.S197N	ACH-000159	Kidney Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1389
p.S197N	OS-RC-2	kidney	COSMIC	KKENK	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_APCC_KENBOX_2	1347:1351	KKENK	APC,CDC20,FZR1	0.6193	More...
P09629	Homeobox protein Hox-B7	DEG_APCC_KENBOX_2	193:197	KKENK	APC,CDC20,FZR1	0.5932	More...
P78411	Iroquois-class homeodomain protein IRX-5	DEG_APCC_KENBOX_2	172:176	KKENK	APC,CDC20,FZR1	0.8587	More...
P78412	Iroquois-class homeodomain protein IRX-6	DEG_APCC_KENBOX_2	205:209	KKENK	APC,CDC20,FZR1	0.8695	More...
P78413	Iroquois-class homeodomain protein IRX-4	DEG_APCC_KENBOX_2	201:205	KKENK	APC,CDC20,FZR1	0.9359	More...
Q9H0A6	RING finger protein 32	DEG_APCC_KENBOX_2	46:50	KKENK	APC,CDC20,FZR1	0.9703	More...
Q9NQS3	Nectin-3	DEG_APCC_KENBOX_2	471:475	KKENK	APC,CDC20,FZR1	0.5241	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_APCC_KENBOX_2	914:918	KKENK	APC,CDC20,FZR1	0.8734	More...
P31267	Homeobox protein Hox-A6	DEG_APCC_KENBOX_2	211:215	KKENK	APC,CDC20,FZR1	0.8614	More...
P78414	Iroquois-class homeodomain protein IRX-1	DEG_APCC_KENBOX_2	186:190	KKENK	APC,CDC20,FZR1	0.8603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKENK

Degron related mutations and impact score

Drug responses associated with IRX1 mutations

All proteins holding degron of KKENK