DegronMD - P78411(IRX5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R169W	TCGA-A5-A0G2	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.25
p.R182Q	TCGA-AJ-A3BH	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1667
p.R182Q	TCGA-AJ-A8CW	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1667
p.T180M	TCGA-AJ-A3EL	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation blocking phosphorylation signal	0.6667
p.R182W	TCGA-AP-A056	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1667
p.R182W	TCGA-AP-A0LM	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1667
p.P21S	TCGA-AP-A0LM	UCEC	TCGA	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.3056
p.P21S	DO43306	UCEC	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.3056
p.R170H	TCGA-AX-A2HH	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.2778
p.A167T	TCGA-B5-A1MW	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1944
p.E186K	TCGA-BS-A0UV	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.0556
p.Y23H	TCGA-CG-5721	STAD	TCGA	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7229
p.Y23H	DO38192	STAD	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7229
p.D34N	TCGA-CN-5360	HNSC	TCGA	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.D34N	DO14662	HNSC	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.T178P	TCGA-D3-A8GR	SKCM	TCGA	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.2778
p.E174D	TCGA-EO-A22X	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation altering degron motif	0.6758
p.S29L	TCGA-FD-A3B5	BLCA	TCGA	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.S29L	DO714	BLCA	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.S19L	TCGA-S5-AA26	BLCA	TCGA	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.S19L	DO51904	BLCA	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.25
p.M177T	TCGA-VS-A8QH	CESC	TCGA	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.3056
p.L182V	DO44049	BLCA	ICGC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1667
p.R180W	DO465	BLCA	ICGC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation blocking phosphorylation signal	0.6667
p.R180W	DO42472	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation blocking phosphorylation signal	0.6667
p.A13V	DO5326	BRCA	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0833
p.A13V	DO42336	UCEC	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0833
p.A13V	DO43186	UCEC	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0833
p.G174D	DO7178	CLLE	ICGC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation altering degron motif	0.7198
p.A186T	DO8119	COAD	ICGC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.0556
p.A28S	DO8424	COAD	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.A28V	DO9788	COAD	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.V27F	DO229019	LICA	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.3056
p.P171A	DO23830	LUAD	ICGC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.3056
p.P171L	DO26608	LUSC	ICGC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.3056
p.P15L	DO222632	MELA	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1389
p.S14F	DO218554	ORCA	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.P20S	DO229479	SKCA	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.G18C	DO47497	SKCM	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2222
p.L31F	DO47491	SKCM	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1944
p.H34Y	DO48667	SKCM	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1111
p.Q167H	DO229259	THCA	ICGC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1944
p.S12P	DO229234	THCA	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0556
p.S12Y	DO223286	UCEC	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0556
p.G26V	DO42472	UCEC	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7532
p.G32E	DO42472	UCEC	ICGC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1667
p.A167V	SIDM00602	Gastric Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1944
p.A167V	ACH-000919	Gastric Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1944
p.A167V	IM-95	stomach	COSMIC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1944
p.P181S	SIDM01175	Other Sarcomas	GDSC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1944
p.P181S	ACH-002309	Sarcoma	CCLE	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1944
p.P181S	SW684	soft tissue	COSMIC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1944
p.T178S	SIDM00282	Colorectal Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.2778
p.T178S	ACH-000998	Colon/Colorectal Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.2778
p.T178S	CW-2	large intestine	COSMIC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.2778
p.L17P	SIDM01051	Ovarian Carcinoma	GDSC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1944
p.L17P	ACH-000936	Ovarian Cancer	CCLE	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1944
p.L17P	EFO-27	ovary	COSMIC	AYSTS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1944
p.S167L	ACH-000725	Breast Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1944
p.S167L	HCC202	breast	COSMIC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1944
p.R164C	ACH-000874	Leukemia	CCLE	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1111
p.R164C	RS4-11	haematopoietic and lymphoid tissue	COSMIC	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.1111
p.A168V	ACH-001377	Pancreatic Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	172:176	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRX5

UniProt ID: P78411

Entrez ID: 10265

Protein name: Iroquois-class homeodomain protein IRX-5 (Homeodomain protein IRX-2A) (Homeodomain protein IRXB2) (Iroquois homeobox protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRX5 in