DegronMD

Uniprot ID: P78411

Source protein: Iroquois-class homeodomain protein IRX-5

Source gene: IRX5

Class: DEG_SPOP_SBC_1

Location: 22:26

E3 ligase: SPOP

DEGRON score: 0.7887

ASA_SCORE: 64.94

COIL: 0.8052

CONS_SCORE: 0.3768

DSS_SCORE: 0.2305

HELIX: 0.1198

FCONS_SCORE: 0.9729

RIG_SCORE: 0.7664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P21S	TCGA-AP-A0LM	UCEC	TCGA	AYSTS	DEG_SPOP_SBC_1	0.3056
p.P21S	DO43306	UCEC	ICGC	AYSTS	DEG_SPOP_SBC_1	0.3056
p.Y23H	TCGA-CG-5721	STAD	TCGA	AYSTS	DEG_SPOP_SBC_1	0.7229
p.Y23H	DO38192	STAD	ICGC	AYSTS	DEG_SPOP_SBC_1	0.7229
p.D34N	TCGA-CN-5360	HNSC	TCGA	AYSTS	DEG_SPOP_SBC_1	0.1111
p.D34N	DO14662	HNSC	ICGC	AYSTS	DEG_SPOP_SBC_1	0.1111
p.S29L	TCGA-FD-A3B5	BLCA	TCGA	AYSTS	DEG_SPOP_SBC_1	0.25
p.S29L	DO714	BLCA	ICGC	AYSTS	DEG_SPOP_SBC_1	0.25
p.S19L	TCGA-S5-AA26	BLCA	TCGA	AYSTS	DEG_SPOP_SBC_1	0.25
p.S19L	DO51904	BLCA	ICGC	AYSTS	DEG_SPOP_SBC_1	0.25
p.A13V	DO5326	BRCA	ICGC	AYSTS	DEG_SPOP_SBC_1	0.0833
p.A13V	DO42336	UCEC	ICGC	AYSTS	DEG_SPOP_SBC_1	0.0833
p.A13V	DO43186	UCEC	ICGC	AYSTS	DEG_SPOP_SBC_1	0.0833
p.A28S	DO8424	COAD	ICGC	AYSTS	DEG_SPOP_SBC_1	0.2778
p.A28V	DO9788	COAD	ICGC	AYSTS	DEG_SPOP_SBC_1	0.2778
p.V27F	DO229019	LICA	ICGC	AYSTS	DEG_SPOP_SBC_1	0.3056
p.P15L	DO222632	MELA	ICGC	AYSTS	DEG_SPOP_SBC_1	0.1389
p.S14F	DO218554	ORCA	ICGC	AYSTS	DEG_SPOP_SBC_1	0.1111
p.P20S	DO229479	SKCA	ICGC	AYSTS	DEG_SPOP_SBC_1	0.2778
p.G18C	DO47497	SKCM	ICGC	AYSTS	DEG_SPOP_SBC_1	0.2222
p.L31F	DO47491	SKCM	ICGC	AYSTS	DEG_SPOP_SBC_1	0.1944
p.H34Y	DO48667	SKCM	ICGC	AYSTS	DEG_SPOP_SBC_1	0.1111
p.S12P	DO229234	THCA	ICGC	AYSTS	DEG_SPOP_SBC_1	0.0556
p.S12Y	DO223286	UCEC	ICGC	AYSTS	DEG_SPOP_SBC_1	0.0556
p.G26V	DO42472	UCEC	ICGC	AYSTS	DEG_SPOP_SBC_1	0.7532
p.G32E	DO42472	UCEC	ICGC	AYSTS	DEG_SPOP_SBC_1	0.1667
p.L17P	SIDM01051	Ovarian Carcinoma	GDSC	AYSTS	DEG_SPOP_SBC_1	0.1944
p.L17P	ACH-000936	Ovarian Cancer	CCLE	AYSTS	DEG_SPOP_SBC_1	0.1944
p.L17P	EFO-27	ovary	COSMIC	AYSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78411	Iroquois-class homeodomain protein IRX-5	DEG_SPOP_SBC_1	22:26	AYSTS	SPOP	0.7887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons