DegronMD

Uniprot ID: Q9H0A6

Source protein: RING finger protein 32

Source gene: RNF32

Class: DEG_APCC_KENBOX_2

Location: 46:50

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9703

ASA_SCORE: 130.74

COIL: 0.7134

CONS_SCORE: 0.4037

DSS_SCORE: 0.5711

HELIX: 0.2678

FCONS_SCORE: 1.0251

RIG_SCORE: 0.7195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K50T	TCGA-A5-A0G2	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.6195
p.K50T	DO41235	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.6195
p.S51Y	TCGA-AJ-A5DW	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.3056
p.S51Y	DO229213	THCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.3056
p.S51Y	DO50075	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.3056
p.I60M	TCGA-CG-5721	STAD	TCGA	KKENK	DEG_APCC_KENBOX_2	0.0556
p.I60M	DO38192	STAD	ICGC	KKENK	DEG_APCC_KENBOX_2	0.0556
p.Q45K	TCGA-EO-A3B0	UCEC	TCGA	KKENK	DEG_APCC_KENBOX_2	0.3056
p.Q45K	DO219773	UCEC	ICGC	KKENK	DEG_APCC_KENBOX_2	0.3056
p.A58V	DO228935	COCA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.1111
p.L52Q	DO232852	NACA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.L52I	DO232852	NACA	ICGC	KKENK	DEG_APCC_KENBOX_2	0.2778
p.Q43P	SIDM01727	Chronic Myelogenous Leukemia	GDSC	KKENK	DEG_APCC_KENBOX_2	0.25
p.Q43P	ACH-000241	Leukemia	CCLE	KKENK	DEG_APCC_KENBOX_2	0.25
p.D55N	SIDM01588	Endometrial Carcinoma	GDSC	KKENK	DEG_APCC_KENBOX_2	0.1944
p.D55N	ACH-000993	Endometrial/Uterine Cancer	CCLE	KKENK	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_APCC_KENBOX_2	1347:1351	KKENK	APC,CDC20,FZR1	0.6193	More...
P09629	Homeobox protein Hox-B7	DEG_APCC_KENBOX_2	193:197	KKENK	APC,CDC20,FZR1	0.5932	More...
P78411	Iroquois-class homeodomain protein IRX-5	DEG_APCC_KENBOX_2	172:176	KKENK	APC,CDC20,FZR1	0.8587	More...
P78412	Iroquois-class homeodomain protein IRX-6	DEG_APCC_KENBOX_2	205:209	KKENK	APC,CDC20,FZR1	0.8695	More...
P78413	Iroquois-class homeodomain protein IRX-4	DEG_APCC_KENBOX_2	201:205	KKENK	APC,CDC20,FZR1	0.9359	More...
Q9H0A6	RING finger protein 32	DEG_APCC_KENBOX_2	46:50	KKENK	APC,CDC20,FZR1	0.9703	More...
Q9NQS3	Nectin-3	DEG_APCC_KENBOX_2	471:475	KKENK	APC,CDC20,FZR1	0.5241	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_APCC_KENBOX_2	914:918	KKENK	APC,CDC20,FZR1	0.8734	More...
P31267	Homeobox protein Hox-A6	DEG_APCC_KENBOX_2	211:215	KKENK	APC,CDC20,FZR1	0.8614	More...
P78414	Iroquois-class homeodomain protein IRX-1	DEG_APCC_KENBOX_2	186:190	KKENK	APC,CDC20,FZR1	0.8603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons