DegronMD

Uniprot ID: Q9Y692

Source protein: Glucocorticoid modulatory element-binding protein 1

Source gene: GMEB1

Class: DEG_SPOP_SBC_1

Location: 455:459

E3 ligase: SPOP

DEGRON score: 0.8751

ASA_SCORE: 81.94

COIL: 0.8584

CONS_SCORE: 0.2295

DSS_SCORE: 0.3577

HELIX: 0.0658

FCONS_SCORE: 0.8363

RIG_SCORE: 0.6205

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R447S	TCGA-AX-A2HC	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	0.1111
p.T462P	TCGA-BT-A42C	BLCA	TCGA	AKSSS	DEG_SPOP_SBC_1	0.25
p.H466Q	TCGA-E2-A1B6	BRCA	TCGA	AKSSS	DEG_SPOP_SBC_1	0.1389
p.R447H	TCGA-EA-A3HS	CESC	TCGA	AKSSS	DEG_SPOP_SBC_1	0.1111
p.R447H	SIDM00828	Other Sarcomas	GDSC	AKSSS	DEG_SPOP_SBC_1	0.1111
p.R447H	SIDM00500	Colorectal Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	0.1111
p.R447H	HT-1080	soft_tissue	COSMIC	AKSSS	DEG_SPOP_SBC_1	0.1111
p.T452P	DO49725	BLCA	ICGC	AKSSS	DEG_SPOP_SBC_1	0.25
p.A462V	DO52630	BOCA	ICGC	AKSSS	DEG_SPOP_SBC_1	0.25
p.H456Q	DO5493	BRCA	ICGC	AKSSS	DEG_SPOP_SBC_1	0.7582
p.S448I	DO229036	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	0.1389
p.K446N	DO50917	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	0.0833
p.K446N	ACH-000769	Lung Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	0.0833
p.K446N	LK-2	lung	COSMIC	AKSSS	DEG_SPOP_SBC_1	0.0833
p.S458N	SIDM00845	Burkitt's Lymphoma	GDSC	AKSSS	DEG_SPOP_SBC_1	0.7069
p.S458N	SIDM00461	Acute Myeloid Leukemia	GDSC	AKSSS	DEG_SPOP_SBC_1	0.7069
p.S458N	SIDM01519	Head and Neck Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	0.7069
p.K456N	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	0.5806
p.K456N	LK-2	lung	COSMIC	AKSSS	DEG_SPOP_SBC_1	0.5806
p.S448N	ACH-000992	Head and Neck Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14647	Chromodomain-helicase-DNA-binding protein 2	DEG_SPOP_SBC_1	1432:1436	AKSSS	SPOP	0.9644	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	1217:1221	AKSSS	SPOP	0.9576	More...
O94762	ATP-dependent DNA helicase Q5	DEG_SPOP_SBC_1	732:736	AKSSS	SPOP	0.7563	More...
O95294	RasGAP-activating-like protein 1	DEG_SPOP_SBC_1	2:6	AKSSS	SPOP	0.7406	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	474:478	AKSSS	SPOP	0.6808	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	282:286	AKSSS	SPOP	0.9674	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1165:1169	AKSSS	SPOP	0.9726	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	755:759	AKSSS	SPOP	0.5292	More...
Q6PRD1	Probable G-protein coupled receptor 179	DEG_SPOP_SBC_1	906:910	AKSSS	SPOP	0.9545	More...
Q8NEY1	Neuron navigator 1	DEG_SPOP_SBC_1	677:681	AKSSS	SPOP	0.9854	More...
Q96PV6	Leukocyte receptor cluster member 8	DEG_SPOP_SBC_1	59:63	AKSSS	SPOP	0.9898	More...
Q9NWH9	SAFB-like transcription modulator	DEG_SPOP_SBC_1	351:355	AKSSS	SPOP	0.9894	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_SPOP_SBC_1	167:171	AKSSS	SPOP	0.989	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	698:702	AKSSS	SPOP	0.9382	More...
Q9Y692	Glucocorticoid modulatory element-binding protein 1	DEG_SPOP_SBC_1	455:459	AKSSS	SPOP	0.8751	More...
Q2TAC6	Kinesin-like protein KIF19	DEG_SPOP_SBC_1	720:724	AKSSS	SPOP	0.9422	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	203:207	AKSSS	SPOP	0.9219	More...
Q5SYE7	NHS-like protein 1	DEG_SPOP_SBC_1	1146:1150	AKSSS	SPOP	0.9831	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	676:680	AKSSS	SPOP	0.9984	More...
A6NCF6	Putative MAGE domain-containing protein MAGEA13P	DEG_SPOP_SBC_1	332:336	AKSSS	SPOP	0.9368	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKSSS

Degron related mutations and impact score

Drug responses associated with GMEB1 mutations

All proteins holding degron of AKSSS