DegronMD - Q9NYV4(CDK12)

FUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic... View more >>

GO - Biological processes (BP): mRNA processing [GO:0006397]; negative regulation of stem cell differentiation [GO:2000737]; phosphorylation of RNA polymerase II C-terminal domain [GO:0070816]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; protein autophosphorylation [GO:0046777]; pr... View more >>

GO - Molecular function (MF): ATP binding [GO:0005524]; cyclin binding [GO:0030332]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein serine kinase activity [GO... View more >>

GO - Cellular component (CC): cyclin/CDK positive transcription elongation factor complex [GO:0008024]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cyclin K-CDK12 complex [GO:0002944]; nuclear cyclin-dependent protein kinase holoenzyme complex [GO:0019908]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R663L	DO224563	LUSC	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation altering degron motif	0.8428
p.R663C	TCGA-CM-4743	COAD	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation altering degron motif	0.8301
p.R663C	TCGA-CM-4746	COAD	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation altering degron motif	0.8301
p.R663C	DO8103	COAD	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation altering degron motif	0.8301
p.R663C	DO7882	COAD	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation altering degron motif	0.8301
p.S265R	TCGA-78-7154	LUAD	TCGA	PGSTS	DEG_SPOP_SBC_1	266:270	Mutation blocking phosphorylation signal	0.75
p.S265R	DO24070	LUAD	ICGC	PGSTS	DEG_SPOP_SBC_1	266:270	Mutation blocking phosphorylation signal	0.75
p.N432H	ACH-001329	Brain Cancer	CCLE	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation altering degron motif	0.7423
p.T581I	TCGA-E1-5307	LGG	TCGA	PASST	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7078
p.T581I	DO22359	LGG	ICGC	PASST	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7078
p.S170N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AKSSS	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7069
p.S170N	ACH-000995	Leukemia	CCLE	AKSSS	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7069
p.S170N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AKSSS	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7069
p.S423L	DO222395	MELA	ICGC	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation blocking phosphorylation signal	0.6111
p.K421N	TCGA-G4-6628	COAD	TCGA	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation blocking ubiquitination signal	0.5556
p.K421N	DO10132	COAD	ICGC	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation blocking ubiquitination signal	0.5556
p.K438R	TCGA-50-5930	LUAD	TCGA	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation substituting flanking lysine	0.3056
p.K438R	DO25189	LUAD	ICGC	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation substituting flanking lysine	0.3056
p.P428R	TCGA-85-8580	LUSC	TCGA	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation rewiring degron network	0.3056
p.P428R	DO45549	LUSC	ICGC	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 64 entries

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Kaplan plot for CDK12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDK12

UniProt ID: Q9NYV4

Entrez ID: 51755

Protein name: Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDK12 in