DegronMD - Q9NYV4(CDK12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S587Y	TCGA-10-0930	OV	TCGA	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1667
p.S587Y	DO32113	OV	ICGC	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1667
p.R449T	TCGA-22-5477	LUSC	TCGA	DSGLES	DEG_SCF_TRCP1_1	439:444	Mutation rewiring degron network	0.1944
p.R449T	DO26894	LUSC	ICGC	DSGLES	DEG_SCF_TRCP1_1	439:444	Mutation rewiring degron network	0.1944
p.P653L	TCGA-29-1711	OV	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation rewiring degron network	0.0833
p.P653L	DO30630	OV	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation rewiring degron network	0.0833
p.G677C	TCGA-35-4122	LUAD	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation rewiring degron network	0.1389
p.G677C	DO23782	LUAD	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation rewiring degron network	0.1389
p.G677D	TCGA-35-4122	LUAD	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation rewiring degron network	0.1389
p.G677D	TCGA-BS-A0UJ	UCEC	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation rewiring degron network	0.1389
p.G677D	DO23782	LUAD	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation rewiring degron network	0.1389
p.G677D	DO42745	UCEC	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation rewiring degron network	0.1389
p.V425A	TCGA-38-4628	LUAD	TCGA	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation rewiring degron network	0.2222
p.V425A	DO26354	LUAD	ICGC	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation rewiring degron network	0.2222
p.K438R	TCGA-50-5930	LUAD	TCGA	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation substituting flanking lysine	0.3056
p.K438R	DO25189	LUAD	ICGC	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation substituting flanking lysine	0.3056
p.S265R	TCGA-78-7154	LUAD	TCGA	PGSTS	DEG_SPOP_SBC_1	266:270	Mutation blocking phosphorylation signal	0.75
p.S265R	DO24070	LUAD	ICGC	PGSTS	DEG_SPOP_SBC_1	266:270	Mutation blocking phosphorylation signal	0.75
p.P428R	TCGA-85-8580	LUSC	TCGA	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation rewiring degron network	0.3056
p.P428R	DO45549	LUSC	ICGC	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation rewiring degron network	0.3056
p.P653H	TCGA-AP-A059	UCEC	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation rewiring degron network	0.0833
p.P653H	DO41361	UCEC	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation rewiring degron network	0.0833
p.R663C	TCGA-CM-4743	COAD	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation altering degron motif	0.8301
p.R663C	TCGA-CM-4746	COAD	TCGA	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation altering degron motif	0.8301
p.R663C	DO8103	COAD	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation altering degron motif	0.8301
p.R663C	DO7882	COAD	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation altering degron motif	0.8301
p.T581I	TCGA-E1-5307	LGG	TCGA	PASST	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7078
p.T581I	DO22359	LGG	ICGC	PASST	DEG_SPOP_SBC_1	577:581	Mutation altering degron motif	0.7078
p.K264N	TCGA-E6-A1LX	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.2778
p.K264N	DO41020	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.2778
p.P585L	TCGA-EB-A3Y7	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.P585L	DO37499	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.P585L	SIDM01398	Melanoma	GDSC	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.P585L	ACH-000661	Skin Cancer	CCLE	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2222
p.F426V	TCGA-FI-A2D5	UCEC	TCGA	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation rewiring degron network	0.25
p.F426V	DO41331	UCEC	ICGC	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation rewiring degron network	0.25
p.K421N	TCGA-G4-6628	COAD	TCGA	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation blocking ubiquitination signal	0.5556
p.K421N	DO10132	COAD	ICGC	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation blocking ubiquitination signal	0.5556
p.P586S	TCGA-GF-A6C9	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1944
p.P586S	DO51254	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1944
p.A572E	TCGA-IN-A6RO	STAD	TCGA	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1944
p.A572E	DO51740	STAD	ICGC	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1944
p.Q575E	TCGA-IN-A6RO	STAD	TCGA	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2778
p.Q575E	DO51740	STAD	ICGC	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.2778
p.P568L	TCGA-WE-A8ZO	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.0833
p.P568L	DO51286	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.0833
p.V654L	DO229052	LICA	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation rewiring degron network	0.1111
p.R663L	DO224563	LUSC	ICGC	TRHLLTDLP	DEG_APCC_DBOX_1	662:670	Mutation altering degron motif	0.8428
p.S423L	DO222395	MELA	ICGC	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation blocking phosphorylation signal	0.6111
p.P278S	DO229446	SKCA	ICGC	PGSTS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.S170N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AKSSS	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7069
p.S170N	ACH-000995	Leukemia	CCLE	AKSSS	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7069
p.S170N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AKSSS	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7069
p.L584F	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.25
p.S587C	SIDM00357	Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1667
p.S587C	ACH-002193	Lung Cancer	CCLE	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1667
p.S587C	RERF-LC-FM	lung	COSMIC	PASST	DEG_SPOP_SBC_1	577:581	Mutation rewiring degron network	0.1667
p.K452T	SIDM00870	Breast Carcinoma	GDSC	DSGLES	DEG_SCF_TRCP1_1	439:444	Mutation substituting flanking lysine	0.2222
p.K452T	HCC202	breast	COSMIC	DSGLES	DEG_SCF_TRCP1_1	439:444	Mutation substituting flanking lysine	0.2222
p.P448H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	DSGLES	DEG_SCF_TRCP1_1	439:444	Mutation rewiring degron network	0.2222
p.P448H	ACH-000874	Leukemia	CCLE	DSGLES	DEG_SCF_TRCP1_1	439:444	Mutation rewiring degron network	0.2222
p.P448H	RS4-11	haematopoietic and lymphoid tissue	COSMIC	DSGLES	DEG_SCF_TRCP1_1	439:444	Mutation rewiring degron network	0.2222
p.N432H	ACH-001329	Brain Cancer	CCLE	RKENS	DEG_APCC_KENBOX_2	429:433	Mutation altering degron motif	0.7423
p.K591E	NCI-H1355	lung	COSMIC	PASST	DEG_SPOP_SBC_1	577:581	Mutation substituting flanking lysine	0.1667

Kaplan plot for CDK12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDK12

UniProt ID: Q9NYV4

Entrez ID: 51755

Protein name: Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDK12 in