DegronMD

Uniprot ID: Q9NYV4

Source protein: Cyclin-dependent kinase 12

Source gene: CDK12

Class: DEG_SCF_TRCP1_1

Location: 439:444

E3 ligase: BTRC

DEGRON score: 0.9986

ASA_SCORE: 84.1833

COIL: 0.7835

CONS_SCORE: 0.3004

DSS_SCORE: 0.5373

HELIX: 0.2097

FCONS_SCORE: 0.9999

RIG_SCORE: 0.654

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R449T	TCGA-22-5477	LUSC	TCGA	DSGLES	DEG_SCF_TRCP1_1	0.1944
p.R449T	DO26894	LUSC	ICGC	DSGLES	DEG_SCF_TRCP1_1	0.1944
p.K452T	SIDM00870	Breast Carcinoma	GDSC	DSGLES	DEG_SCF_TRCP1_1	0.2222
p.K452T	HCC202	breast	COSMIC	DSGLES	DEG_SCF_TRCP1_1	0.2222
p.P448H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	DSGLES	DEG_SCF_TRCP1_1	0.2222
p.P448H	ACH-000874	Leukemia	CCLE	DSGLES	DEG_SCF_TRCP1_1	0.2222
p.P448H	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLES	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NBR6	Ubiquitin carboxyl-terminal hydrolase MINDY-2	DEG_SCF_TRCP1_1	89:94	DSGLES	BTRC	0.9992	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_SCF_TRCP1_1	439:444	DSGLES	BTRC	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons