FUNCTION: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of pro...
FUNCTION: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798). {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}.
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GO - Biological processes (BP):
protein K48-linked deubiquitination [GO:0071108]...
protein K48-linked deubiquitination [GO:0071108]
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GO - Molecular function (MF):
cysteine-type carboxypeptidase activity [GO:0016807]; K11-linked polyubiquitin modification-dependent protein binding [GO:0071795]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; K6-linked po...
cysteine-type carboxypeptidase activity [GO:0016807]; K11-linked polyubiquitin modification-dependent protein binding [GO:0071795]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; K6-linked polyubiquitin modification-dependent protein binding [GO:0071796]; Lys48-specific deubiquitinase activity [GO:1990380]; thiol-dependent deubiquitinase [GO:0004843]
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GO - Cellular component (CC):
nucleoplasm [GO:0005654]...
nucleoplasm [GO:0005654]
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