DegronMD

Uniprot ID: Q8NBR6

Source protein: Ubiquitin carboxyl-terminal hydrolase MINDY-2

Source gene: MINDY2

Class: DEG_SCF_TRCP1_1

Location: 89:94

E3 ligase: BTRC

DEGRON score: 0.9992

ASA_SCORE: 80.05

COIL: 0.874

CONS_SCORE: 0.1897

DSS_SCORE: 0.5588

HELIX: 0.1075

FCONS_SCORE: 0.998

RIG_SCORE: 0.6559

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D89V	SIDM01960	Colorectal Carcinoma	GDSC	DSGLES	DEG_SCF_TRCP1_1	0.7785

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYV4	Cyclin-dependent kinase 12	DEG_SCF_TRCP1_1	439:444	DSGLES	BTRC	0.9986	More...
Q8NBR6	Ubiquitin carboxyl-terminal hydrolase MINDY-2	DEG_SCF_TRCP1_1	89:94	DSGLES	BTRC	0.9992	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons