DegronMD

Uniprot ID: Q9NYV4

Source protein: Cyclin-dependent kinase 12

Source gene: CDK12

Class: DEG_SPOP_SBC_1

Location: 577:581

E3 ligase: SPOP

DEGRON score: 0.9633

ASA_SCORE: 80.18

COIL: 0.948

CONS_SCORE: 0.3096

DSS_SCORE: 0.7032

HELIX: 0.0388

FCONS_SCORE: 0.9874

RIG_SCORE: 0.5523

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S587Y	TCGA-10-0930	OV	TCGA	PASST	DEG_SPOP_SBC_1	0.1667
p.S587Y	DO32113	OV	ICGC	PASST	DEG_SPOP_SBC_1	0.1667
p.T581I	TCGA-E1-5307	LGG	TCGA	PASST	DEG_SPOP_SBC_1	0.7078
p.T581I	DO22359	LGG	ICGC	PASST	DEG_SPOP_SBC_1	0.7078
p.P585L	TCGA-EB-A3Y7	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	0.2222
p.P585L	DO37499	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	0.2222
p.P585L	SIDM01398	Melanoma	GDSC	PASST	DEG_SPOP_SBC_1	0.2222
p.P585L	ACH-000661	Skin Cancer	CCLE	PASST	DEG_SPOP_SBC_1	0.2222
p.P586S	TCGA-GF-A6C9	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	0.1944
p.P586S	DO51254	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	0.1944
p.A572E	TCGA-IN-A6RO	STAD	TCGA	PASST	DEG_SPOP_SBC_1	0.1944
p.A572E	DO51740	STAD	ICGC	PASST	DEG_SPOP_SBC_1	0.1944
p.Q575E	TCGA-IN-A6RO	STAD	TCGA	PASST	DEG_SPOP_SBC_1	0.2778
p.Q575E	DO51740	STAD	ICGC	PASST	DEG_SPOP_SBC_1	0.2778
p.P568L	TCGA-WE-A8ZO	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	0.0833
p.P568L	DO51286	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	0.0833
p.L584F	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.25
p.S587C	SIDM00357	Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	0.1667
p.S587C	ACH-002193	Lung Cancer	CCLE	PASST	DEG_SPOP_SBC_1	0.1667
p.S587C	RERF-LC-FM	lung	COSMIC	PASST	DEG_SPOP_SBC_1	0.1667
p.K591E	NCI-H1355	lung	COSMIC	PASST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00151	PDZ and LIM domain protein 1	DEG_SPOP_SBC_1	131:135	PASST	SPOP	0.996	More...
O00512	B-cell CLL/lymphoma 9 protein	DEG_SPOP_SBC_1	292:296	PASST	SPOP	0.9897	More...
O00592	Podocalyxin	DEG_SPOP_SBC_1	284:288	PASST	SPOP	0.9958	More...
O15014	Zinc finger protein 609	DEG_SPOP_SBC_1	422:426	PASST	SPOP	0.9985	More...
O43278	Kunitz-type protease inhibitor 1	DEG_SPOP_SBC_1	506:510	PASST	SPOP	0.8248	More...
O43439	Protein CBFA2T2	DEG_SPOP_SBC_1	94:98	PASST	SPOP	0.9026	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1759:1763	PASST	SPOP	0.8173	More...
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	471:475	PASST	SPOP	0.9789	More...
P55317	Hepatocyte nuclear factor 3-alpha	DEG_SPOP_SBC_1	352:356	PASST	SPOP	0.9993	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	276:280	PASST	SPOP	0.9862	More...
Q07157	Tight junction protein ZO-1	DEG_SPOP_SBC_1	938:942	PASST	SPOP	0.9965	More...
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SPOP_SBC_1	85:89	PASST	SPOP	0.795	More...
Q5T7P8	Synaptotagmin-6	DEG_SPOP_SBC_1	166:170	PASST	SPOP	0.9966	More...
Q6H8Q1	Actin-binding LIM protein 2	DEG_SPOP_SBC_1	287:291	PASST	SPOP	0.9851	More...
Q7Z4V0	Zinc finger protein 438	DEG_SPOP_SBC_1	220:224	PASST	SPOP	0.996	More...
Q86YR7	Probable guanine nucleotide exchange factor MCF2L2	DEG_SPOP_SBC_1	997:1001	PASST	SPOP	0.999	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	455:459	PASST	SPOP	0.9441	More...
Q8IWZ8	SURP and G-patch domain-containing protein 1	DEG_SPOP_SBC_1	354:358	PASST	SPOP	0.9845	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1155:1159	PASST	SPOP	0.7698	More...
Q8N122	Regulatory-associated protein of mTOR	DEG_SPOP_SBC_1	879:883	PASST	SPOP	0.9966	More...
Q8N3J3	Homologous recombination OB-fold protein	DEG_SPOP_SBC_1	82:86	PASST	SPOP	0.9981	More...
Q8WXH0	Nesprin-2	DEG_SPOP_SBC_1	6481:6485	PASST	SPOP	0.9986	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	654:658	PASST	SPOP	0.7201	More...
Q99717	Mothers against decapentaplegic homolog 5	DEG_SPOP_SBC_1	197:201	PASST	SPOP	0.992	More...
Q9BQL6	Fermitin family homolog 1	DEG_SPOP_SBC_1	198:202	PASST	SPOP	0.9238	More...
Q9H0C8	Integrin-linked kinase-associated serine/threonine phosphatase 2C	DEG_SPOP_SBC_1	34:38	PASST	SPOP	0.9084	More...
Q9H9P5	Putative E3 ubiquitin-protein ligase UNKL	DEG_SPOP_SBC_1	409:413	PASST	SPOP	0.8044	More...
Q9HC52	Chromobox protein homolog 8	DEG_SPOP_SBC_1	132:136	PASST	SPOP	0.981	More...
Q9NR12	PDZ and LIM domain protein 7	DEG_SPOP_SBC_1	201:205	PASST	SPOP	0.9989	More...
Q9NUT2	Mitochondrial potassium channel ATP-binding subunit	DEG_SPOP_SBC_1	120:124	PASST	SPOP	0.6141	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_SPOP_SBC_1	577:581	PASST	SPOP	0.9633	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1122:1126	PASST	SPOP	0.7308	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1568:1572	PASST	SPOP	0.6922	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2205:2209	PASST	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2260:2264	PASST	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2734:2738	PASST	SPOP	0.7308	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3125:3129	PASST	SPOP	0.9182	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4208:4212	PASST	SPOP	0.8995	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SPOP_SBC_1	1159:1163	PASST	SPOP	0.9943	More...
Q9Y6C2	EMILIN-1	DEG_SPOP_SBC_1	139:143	PASST	SPOP	0.9942	More...
P52746	Zinc finger protein 142	DEG_SPOP_SBC_1	10:14	PASST	SPOP	0.9427	More...
Q2M3G4	Protein Shroom1	DEG_SPOP_SBC_1	13:17	PASST	SPOP	0.9978	More...
D6RIA3	Uncharacterized protein C4orf54	DEG_SPOP_SBC_1	1735:1739	PASST	SPOP	0.9207	More...
Q5T5J6	Transcriptional protein SWT1	DEG_SPOP_SBC_1	36:40	PASST	SPOP	0.9757	More...
Q9C0I3	Serine-rich coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	650:654	PASST	SPOP	0.6155	More...
Q6ZNG2	Homeobox protein DBX2	DEG_SPOP_SBC_1	159:163	PASST	SPOP	0.861	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASST

Degron related mutations and impact score

Drug responses associated with CDK12 mutations

All proteins holding degron of PASST