DegronMD - O15014(ZNF609)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A674P	TCGA-12-1089	GBM	TCGA	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1389
p.A674P	DO12346	GBM	ICGC	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1389
p.P681L	TCGA-21-1079	LUSC	TCGA	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.7582
p.P681L	DO26846	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.7582
p.G682D	TCGA-AP-A0LM	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.6087
p.G682D	DO43306	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.6087
p.V153I	TCGA-B6-A0IJ	BRCA	TCGA	EKENS	DEG_APCC_KENBOX_2	159:163	Mutation rewiring degron network	0.1667
p.V153I	DO2813	BRCA	ICGC	EKENS	DEG_APCC_KENBOX_2	159:163	Mutation rewiring degron network	0.1667
p.A692T	TCGA-BR-6852	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1389
p.A692T	DO38202	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1389
p.P102L	TCGA-D3-A5GO	SKCM	TCGA	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation altering degron motif	0.6471
p.P102L	DO47419	SKCM	ICGC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation altering degron motif	0.6471
p.S165F	TCGA-D3-A8GK	SKCM	TCGA	EKENS	DEG_APCC_KENBOX_2	159:163	Mutation blocking phosphorylation signal	0.7222
p.S165F	DO50286	SKCM	ICGC	EKENS	DEG_APCC_KENBOX_2	159:163	Mutation blocking phosphorylation signal	0.7222
p.D98Y	TCGA-DU-6392	LGG	TCGA	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.2222
p.D98Y	DO22237	LGG	ICGC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.2222
p.R151S	TCGA-EE-A2M7	SKCM	TCGA	EKENS	DEG_APCC_KENBOX_2	159:163	Mutation rewiring degron network	0.1111
p.R151S	DO37847	SKCM	ICGC	EKENS	DEG_APCC_KENBOX_2	159:163	Mutation rewiring degron network	0.1111
p.S107F	TCGA-EE-A2MJ	SKCM	TCGA	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation altering degron motif	0.9093
p.S107F	DO38099	SKCM	ICGC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation altering degron motif	0.9093
p.P111Q	TCGA-FS-A1ZJ	SKCM	TCGA	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.2222
p.P111Q	DO37956	SKCM	ICGC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.2222
p.V430F	TCGA-NJ-A4YQ	LUAD	TCGA	PASST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2222
p.V430F	DO218944	LUAD	ICGC	PASST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2222
p.S684Y	TCGA-WE-A8K4	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.712
p.S684Y	DO51281	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.712
p.S95R	TCGA-ZF-A9RG	BLCA	TCGA	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation blocking phosphorylation signal	0.5833
p.S95R	DO219076	BLCA	ICGC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation blocking phosphorylation signal	0.5833
p.L108M	DO222501	COCA	ICGC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.3056
p.G155S	DO222762	COCA	ICGC	EKENS	DEG_APCC_KENBOX_2	159:163	Mutation rewiring degron network	0.2222
p.R420H	DO234240	ESAD	ICGC	PASST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2778
p.T106I	DO234299	ESAD	ICGC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation altering degron motif	0.7078
p.S433I	DO234406	ESAD	ICGC	PASST	DEG_SPOP_SBC_1	422:426	Mutation blocking phosphorylation signal	0.5833
p.A115T	DO233764	GACA	ICGC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.1111
p.R420L	DO228952	LICA	ICGC	PASST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2778
p.R420L	DO229034	LICA	ICGC	PASST	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2778
p.G155V	DO228974	LICA	ICGC	EKENS	DEG_APCC_KENBOX_2	159:163	Mutation rewiring degron network	0.2222
p.M695I	DO228971	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.0556
p.T99A	SIDM00845	Burkitt's Lymphoma	GDSC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.25
p.T99A	SIDM00461	Acute Myeloid Leukemia	GDSC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.25
p.T99A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.25
p.T99A	SIDM01519	Head and Neck Carcinoma	GDSC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.25
p.T99A	ACH-000992	Head and Neck Cancer	CCLE	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.25
p.T99A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.25
p.T99A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.25
p.K169N	SIDM00789	Colorectal Carcinoma	GDSC	EKENS	DEG_APCC_KENBOX_2	159:163	Mutation substituting flanking lysine	0.2778
p.K169N	ACH-000997	Colon/Colorectal Cancer	CCLE	EKENS	DEG_APCC_KENBOX_2	159:163	Mutation substituting flanking lysine	0.2778
p.K169N	HCT-15	large intestine	COSMIC	EKENS	DEG_APCC_KENBOX_2	159:163	Mutation substituting flanking lysine	0.2778
p.K101T	SIDM00654	Small Cell Lung Carcinoma	GDSC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.3056
p.K101T	SIDM01664	Prostate Carcinoma	GDSC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.3056
p.T673A	SIDM00217	Colorectal Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1111
p.T673A	ACH-000999	Colon/Colorectal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1111
p.T673A	SNU-1040	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1111
p.T110S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PTPGTS	DEG_SCF_FBW7_1	102:107	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF609

UniProt ID: O15014

Entrez ID: 23060

Protein name: Zinc finger protein 609

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF609 in