DegronMD

Uniprot ID: O15014

Source protein: Zinc finger protein 609

Source gene: ZNF609

Class: DEG_APCC_KENBOX_2

Location: 159:163

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.903

ASA_SCORE: 115.3

COIL: 0.729

CONS_SCORE: 0.402

DSS_SCORE: 0.6332

HELIX: 0.2696

FCONS_SCORE: 0.9658

RIG_SCORE: 0.5745

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V153I	TCGA-B6-A0IJ	BRCA	TCGA	EKENS	DEG_APCC_KENBOX_2	0.1667
p.V153I	DO2813	BRCA	ICGC	EKENS	DEG_APCC_KENBOX_2	0.1667
p.S165F	TCGA-D3-A8GK	SKCM	TCGA	EKENS	DEG_APCC_KENBOX_2	0.7222
p.S165F	DO50286	SKCM	ICGC	EKENS	DEG_APCC_KENBOX_2	0.7222
p.R151S	TCGA-EE-A2M7	SKCM	TCGA	EKENS	DEG_APCC_KENBOX_2	0.1111
p.R151S	DO37847	SKCM	ICGC	EKENS	DEG_APCC_KENBOX_2	0.1111
p.G155S	DO222762	COCA	ICGC	EKENS	DEG_APCC_KENBOX_2	0.2222
p.G155V	DO228974	LICA	ICGC	EKENS	DEG_APCC_KENBOX_2	0.2222
p.K169N	SIDM00789	Colorectal Carcinoma	GDSC	EKENS	DEG_APCC_KENBOX_2	0.2778
p.K169N	ACH-000997	Colon/Colorectal Cancer	CCLE	EKENS	DEG_APCC_KENBOX_2	0.2778
p.K169N	HCT-15	large_intestine	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15014	Zinc finger protein 609	DEG_APCC_KENBOX_2	159:163	EKENS	APC,CDC20,FZR1	0.903	More...
Q13426	DNA repair protein XRCC4	DEG_APCC_KENBOX_2	295:299	EKENS	APC,CDC20,FZR1	0.9752	More...
Q2NKX8	DNA excision repair protein ERCC-6-like	DEG_APCC_KENBOX_2	976:980	EKENS	APC,CDC20,FZR1	0.9554	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_APCC_KENBOX_2	1179:1183	EKENS	APC,CDC20,FZR1	0.8074	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_APCC_KENBOX_2	621:625	EKENS	APC,CDC20,FZR1	0.766	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons