DegronMD

Uniprot ID: Q96T88

Source protein: E3 ubiquitin-protein ligase UHRF1

Source gene: UHRF1

Class: DEG_APCC_KENBOX_2

Location: 621:625

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.766

ASA_SCORE: 107.92

COIL: 0.5684

CONS_SCORE: 0.3892

DSS_SCORE: 0.6544

HELIX: 0.4316

FCONS_SCORE: 1.183

RIG_SCORE: 0.6597

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R631Q	SIDM00987	Thyroid Gland Carcinoma	GDSC	EKENS	DEG_APCC_KENBOX_2	0.1667
p.R631Q	BHT-101	thyroid	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.1667
p.E628K	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.25
p.R618Q	BHT-101	thyroid	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.25
p.R618H	SNU-1040	large_intestine	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.25
p.D620N	IGROV-1	ovary	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15014	Zinc finger protein 609	DEG_APCC_KENBOX_2	159:163	EKENS	APC,CDC20,FZR1	0.903	More...
Q13426	DNA repair protein XRCC4	DEG_APCC_KENBOX_2	295:299	EKENS	APC,CDC20,FZR1	0.9752	More...
Q2NKX8	DNA excision repair protein ERCC-6-like	DEG_APCC_KENBOX_2	976:980	EKENS	APC,CDC20,FZR1	0.9554	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_APCC_KENBOX_2	1179:1183	EKENS	APC,CDC20,FZR1	0.8074	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_APCC_KENBOX_2	621:625	EKENS	APC,CDC20,FZR1	0.766	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons