DegronMD

Uniprot ID: Q2NKX8

Source protein: DNA excision repair protein ERCC-6-like

Source gene: ERCC6L

Class: DEG_APCC_KENBOX_2

Location: 976:980

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9554

ASA_SCORE: 103.26

COIL: 0.5472

CONS_SCORE: 0.2407

DSS_SCORE: 0.4568

HELIX: 0.4338

FCONS_SCORE: 0.9803

RIG_SCORE: 0.7251

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N987S	TCGA-19-5951	GBM	TCGA	EKENS	DEG_APCC_KENBOX_2	0.1389
p.N987S	DO14067	GBM	ICGC	EKENS	DEG_APCC_KENBOX_2	0.1389
p.E976D	TCGA-A2-A0EY	BRCA	TCGA	EKENS	DEG_APCC_KENBOX_2	0.5647
p.E976D	DO3614	BRCA	ICGC	EKENS	DEG_APCC_KENBOX_2	0.5647
p.E976D	SIDM01105	Melanoma	GDSC	EKENS	DEG_APCC_KENBOX_2	0.5647
p.E976D	SK-MEL-3	skin	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.5647
p.N966K	TCGA-BR-8372	STAD	TCGA	EKENS	DEG_APCC_KENBOX_2	0.0556
p.N966K	DO47873	STAD	ICGC	EKENS	DEG_APCC_KENBOX_2	0.0556
p.P986R	TCGA-CR-7379	HNSC	TCGA	EKENS	DEG_APCC_KENBOX_2	0.1667
p.P986R	DO14174	HNSC	ICGC	EKENS	DEG_APCC_KENBOX_2	0.1667
p.V975G	TCGA-D5-6533	COAD	TCGA	EKENS	DEG_APCC_KENBOX_2	0.3056
p.V975G	DO8280	COAD	ICGC	EKENS	DEG_APCC_KENBOX_2	0.3056
p.S969N	TCGA-DU-6407	LGG	TCGA	EKENS	DEG_APCC_KENBOX_2	0.5833
p.S969N	DO22295	LGG	ICGC	EKENS	DEG_APCC_KENBOX_2	0.5833
p.S988C	DO225363	BRCA	ICGC	EKENS	DEG_APCC_KENBOX_2	0.5556
p.E978Q	SIDM00457	Plasma Cell Myeloma	GDSC	EKENS	DEG_APCC_KENBOX_2	0.6744
p.E978Q	ACH-000057	Myeloma	CCLE	EKENS	DEG_APCC_KENBOX_2	0.6744
p.E978Q	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.6744
p.S966C	ACH-000711	Breast Cancer	CCLE	EKENS	DEG_APCC_KENBOX_2	0.0556
p.S966C	JIMT-1	breast	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.0556
p.R990I	ACH-000993	Endometrial/Uterine Cancer	CCLE	EKENS	DEG_APCC_KENBOX_2	0.0556
p.R968K	ACH-001081	Colon/Colorectal Cancer	CCLE	EKENS	DEG_APCC_KENBOX_2	0.5556
p.R968K	HCC2998	large_intestine	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15014	Zinc finger protein 609	DEG_APCC_KENBOX_2	159:163	EKENS	APC,CDC20,FZR1	0.903	More...
Q13426	DNA repair protein XRCC4	DEG_APCC_KENBOX_2	295:299	EKENS	APC,CDC20,FZR1	0.9752	More...
Q2NKX8	DNA excision repair protein ERCC-6-like	DEG_APCC_KENBOX_2	976:980	EKENS	APC,CDC20,FZR1	0.9554	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_APCC_KENBOX_2	1179:1183	EKENS	APC,CDC20,FZR1	0.8074	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_APCC_KENBOX_2	621:625	EKENS	APC,CDC20,FZR1	0.766	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons