DegronMD - Q2NKX8(ERCC6L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1090I	TCGA-19-1789	GBM	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation rewiring degron network	0.1944
p.R1090I	DO13210	GBM	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation rewiring degron network	0.1944
p.N987S	TCGA-19-5951	GBM	TCGA	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation rewiring degron network	0.1389
p.N987S	DO14067	GBM	ICGC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation rewiring degron network	0.1389
p.E976D	TCGA-A2-A0EY	BRCA	TCGA	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation altering degron motif	0.5647
p.E976D	DO3614	BRCA	ICGC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation altering degron motif	0.5647
p.E976D	SIDM01105	Melanoma	GDSC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation altering degron motif	0.5647
p.E976D	SK-MEL-3	skin	COSMIC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation altering degron motif	0.5647
p.M1087I	TCGA-A5-A0G5	UCEC	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation rewiring degron network	0.1111
p.M1087I	DO41416	UCEC	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation rewiring degron network	0.1111
p.N1101I	TCGA-A6-5661	COAD	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation altering degron motif	0.6169
p.N1101I	DO8634	COAD	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation altering degron motif	0.6169
p.V1103A	TCGA-B5-A11E	UCEC	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation altering degron motif	0.5825
p.V1103A	DO41644	UCEC	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation altering degron motif	0.5825
p.M1087V	TCGA-BR-4184	STAD	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation rewiring degron network	0.1111
p.M1087V	DO38328	STAD	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation rewiring degron network	0.1111
p.N966K	TCGA-BR-8372	STAD	TCGA	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation rewiring degron network	0.0556
p.N966K	TCGA-BR-8372	STAD	TCGA	FNLFLE	LIG_APCC_ABBA_1	953:958	Mutation rewiring degron network	0.1111
p.N966K	DO47873	STAD	ICGC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation rewiring degron network	0.0556
p.N966K	DO47873	STAD	ICGC	FNLFLE	LIG_APCC_ABBA_1	953:958	Mutation rewiring degron network	0.1111
p.S1086Y	TCGA-BS-A0TC	UCEC	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation blocking phosphorylation signal	0.5278
p.S1086Y	DO42400	UCEC	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation blocking phosphorylation signal	0.5278
p.P986R	TCGA-CR-7379	HNSC	TCGA	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation rewiring degron network	0.1667
p.P986R	DO14174	HNSC	ICGC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation rewiring degron network	0.1667
p.V975G	TCGA-D5-6533	COAD	TCGA	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation rewiring degron network	0.3056
p.V975G	DO8280	COAD	ICGC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation rewiring degron network	0.3056
p.S969N	TCGA-DU-6407	LGG	TCGA	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation blocking phosphorylation signal	0.5833
p.S969N	DO22295	LGG	ICGC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation blocking phosphorylation signal	0.5833
p.S1092Y	TCGA-ND-A4WC	UCS	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation rewiring degron network	0.25
p.S988C	DO225363	BRCA	ICGC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation blocking phosphorylation signal	0.5556
p.K1085T	DO233206	GACA	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation blocking ubiquitination signal	0.5
p.E1108Q	DO52692	MALY	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation rewiring degron network	0.1944
p.S1089C	SIDM01037	Breast Carcinoma	GDSC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation blocking phosphorylation signal	0.6111
p.S1089C	JIMT-1	breast	COSMIC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation blocking phosphorylation signal	0.6111
p.A944E	SIDM00781	Colorectal Carcinoma	GDSC	FNLFLE	LIG_APCC_ABBA_1	953:958	Mutation rewiring degron network	0.0833
p.A944E	SIDM00780	Colorectal Carcinoma	GDSC	FNLFLE	LIG_APCC_ABBA_1	953:958	Mutation rewiring degron network	0.0833
p.A944E	SNU-C2B	large intestine	COSMIC	FNLFLE	LIG_APCC_ABBA_1	953:958	Mutation rewiring degron network	0.0833
p.E978Q	SIDM00457	Plasma Cell Myeloma	GDSC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation altering degron motif	0.6744
p.E978Q	ACH-000057	Myeloma	CCLE	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation altering degron motif	0.6744
p.E978Q	OPM-2	haematopoietic and lymphoid tissue	COSMIC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation altering degron motif	0.6744
p.R1091K	SIDM00118	Colorectal Carcinoma	GDSC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation rewiring degron network	0.2222
p.R1091K	HCC2998	large intestine	COSMIC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation rewiring degron network	0.2222
p.E958D	SIDM00118	Colorectal Carcinoma	GDSC	FNLFLE	LIG_APCC_ABBA_1	953:958	Mutation altering degron motif	0.5647
p.E958D	HCC2998	large intestine	COSMIC	FNLFLE	LIG_APCC_ABBA_1	953:958	Mutation altering degron motif	0.5647
p.R1113I	SIDM01588	Endometrial Carcinoma	GDSC	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation rewiring degron network	0.0556
p.L955I	SIDM01588	Endometrial Carcinoma	GDSC	FNLFLE	LIG_APCC_ABBA_1	953:958	Mutation altering degron motif	0.6063
p.S966C	ACH-000711	Breast Cancer	CCLE	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation rewiring degron network	0.0556
p.S966C	ACH-000711	Breast Cancer	CCLE	FNLFLE	LIG_APCC_ABBA_1	953:958	Mutation rewiring degron network	0.1111
p.S966C	JIMT-1	breast	COSMIC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation rewiring degron network	0.0556
p.S966C	JIMT-1	breast	COSMIC	FNLFLE	LIG_APCC_ABBA_1	953:958	Mutation rewiring degron network	0.1111
p.L1104F	ACH-000993	Endometrial/Uterine Cancer	CCLE	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation rewiring degron network	0.3056
p.N1098H	ACH-000993	Endometrial/Uterine Cancer	CCLE	SRRSLINMV	DEG_APCC_DBOX_1	1095:1103	Mutation altering degron motif	0.7423
p.R990I	ACH-000993	Endometrial/Uterine Cancer	CCLE	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation rewiring degron network	0.0556
p.R968K	ACH-001081	Colon/Colorectal Cancer	CCLE	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation blocking phosphorylation signal	0.5556
p.R968K	ACH-001081	Colon/Colorectal Cancer	CCLE	FNLFLE	LIG_APCC_ABBA_1	953:958	Mutation blocking phosphorylation signal	0.5
p.R968K	HCC2998	large intestine	COSMIC	EKENS	DEG_APCC_KENBOX_2	976:980	Mutation blocking phosphorylation signal	0.5556
p.R968K	HCC2998	large intestine	COSMIC	FNLFLE	LIG_APCC_ABBA_1	953:958	Mutation blocking phosphorylation signal	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ERCC6L

UniProt ID: Q2NKX8

Entrez ID: 54821

Protein name: DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ERCC6L in