DegronMD

Uniprot ID: Q2NKX8

Source protein: DNA excision repair protein ERCC-6-like

Source gene: ERCC6L

Class: DEG_APCC_DBOX_1

Location: 1095:1103

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9355

ASA_SCORE: 85.2

COIL: 0.4116

CONS_SCORE: 0.2778

DSS_SCORE: 0.4367

HELIX: 0.5184

FCONS_SCORE: 1.1322

RIG_SCORE: 0.7299

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1090I	TCGA-19-1789	GBM	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	0.1944
p.R1090I	DO13210	GBM	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	0.1944
p.M1087I	TCGA-A5-A0G5	UCEC	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	0.1111
p.M1087I	DO41416	UCEC	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	0.1111
p.N1101I	TCGA-A6-5661	COAD	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	0.6169
p.N1101I	DO8634	COAD	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	0.6169
p.V1103A	TCGA-B5-A11E	UCEC	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	0.5825
p.V1103A	DO41644	UCEC	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	0.5825
p.M1087V	TCGA-BR-4184	STAD	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	0.1111
p.M1087V	DO38328	STAD	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	0.1111
p.S1086Y	TCGA-BS-A0TC	UCEC	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	0.5278
p.S1086Y	DO42400	UCEC	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	0.5278
p.S1092Y	TCGA-ND-A4WC	UCS	TCGA	SRRSLINMV	DEG_APCC_DBOX_1	0.25
p.K1085T	DO233206	GACA	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	0.5
p.E1108Q	DO52692	MALY	ICGC	SRRSLINMV	DEG_APCC_DBOX_1	0.1944
p.S1089C	SIDM01037	Breast Carcinoma	GDSC	SRRSLINMV	DEG_APCC_DBOX_1	0.6111
p.S1089C	JIMT-1	breast	COSMIC	SRRSLINMV	DEG_APCC_DBOX_1	0.6111
p.R1091K	SIDM00118	Colorectal Carcinoma	GDSC	SRRSLINMV	DEG_APCC_DBOX_1	0.2222
p.R1091K	HCC2998	large_intestine	COSMIC	SRRSLINMV	DEG_APCC_DBOX_1	0.2222
p.R1113I	SIDM01588	Endometrial Carcinoma	GDSC	SRRSLINMV	DEG_APCC_DBOX_1	0.0556
p.L1104F	ACH-000993	Endometrial/Uterine Cancer	CCLE	SRRSLINMV	DEG_APCC_DBOX_1	0.3056
p.N1098H	ACH-000993	Endometrial/Uterine Cancer	CCLE	SRRSLINMV	DEG_APCC_DBOX_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2NKX8	DNA excision repair protein ERCC-6-like	DEG_APCC_DBOX_1	1095:1103	SRRSLINMV	APC,CDC20,FZR1	0.9355	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons