DegronMD

Uniprot ID: Q2NKX8

Source protein: DNA excision repair protein ERCC-6-like

Source gene: ERCC6L

Class: LIG_APCC_ABBA_1

Location: 953:958

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9092

ASA_SCORE: 84.6

COIL: 0.5517

CONS_SCORE: 0.2735

DSS_SCORE: 0.425

HELIX: 0.1598

FCONS_SCORE: 1.07

RIG_SCORE: 0.8115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N966K	TCGA-BR-8372	STAD	TCGA	FNLFLE	LIG_APCC_ABBA_1	0.1111
p.N966K	DO47873	STAD	ICGC	FNLFLE	LIG_APCC_ABBA_1	0.1111
p.A944E	SIDM00781	Colorectal Carcinoma	GDSC	FNLFLE	LIG_APCC_ABBA_1	0.0833
p.A944E	SIDM00780	Colorectal Carcinoma	GDSC	FNLFLE	LIG_APCC_ABBA_1	0.0833
p.A944E	SNU-C2B	large_intestine	COSMIC	FNLFLE	LIG_APCC_ABBA_1	0.0833
p.E958D	SIDM00118	Colorectal Carcinoma	GDSC	FNLFLE	LIG_APCC_ABBA_1	0.5647
p.E958D	HCC2998	large_intestine	COSMIC	FNLFLE	LIG_APCC_ABBA_1	0.5647
p.L955I	SIDM01588	Endometrial Carcinoma	GDSC	FNLFLE	LIG_APCC_ABBA_1	0.6063
p.S966C	ACH-000711	Breast Cancer	CCLE	FNLFLE	LIG_APCC_ABBA_1	0.1111
p.S966C	JIMT-1	breast	COSMIC	FNLFLE	LIG_APCC_ABBA_1	0.1111
p.R968K	ACH-001081	Colon/Colorectal Cancer	CCLE	FNLFLE	LIG_APCC_ABBA_1	0.5
p.R968K	HCC2998	large_intestine	COSMIC	FNLFLE	LIG_APCC_ABBA_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2NKX8	DNA excision repair protein ERCC-6-like	LIG_APCC_ABBA_1	953:958	FNLFLE	APC,CDC20,FZR1	0.9092	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons