DegronMD

Uniprot ID: Q13426

Source protein: DNA repair protein XRCC4

Source gene: XRCC4

Class: DEG_APCC_KENBOX_2

Location: 295:299

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9752

ASA_SCORE: 118.6

COIL: 0.7992

CONS_SCORE: 0.5146

DSS_SCORE: 0.8368

HELIX: 0.1752

FCONS_SCORE: 1.0205

RIG_SCORE: 0.5827

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q289H	TCGA-05-4424	LUAD	TCGA	EKENS	DEG_APCC_KENBOX_2	0.1667
p.Q289H	TCGA-BR-6852	STAD	TCGA	EKENS	DEG_APCC_KENBOX_2	0.1667
p.Q289H	DO23672	LUAD	ICGC	EKENS	DEG_APCC_KENBOX_2	0.1667
p.Q289H	DO38202	STAD	ICGC	EKENS	DEG_APCC_KENBOX_2	0.1667
p.Q289H	SIDM00333	Endometrial Carcinoma	GDSC	EKENS	DEG_APCC_KENBOX_2	0.1667
p.Q289H	ACH-000988	Endometrial/Uterine Cancer	CCLE	EKENS	DEG_APCC_KENBOX_2	0.1667
p.Q289H	MFE-319	endometrium	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.1667
p.T308M	TCGA-A5-A0G2	UCEC	TCGA	EKENS	DEG_APCC_KENBOX_2	0.0833
p.T308M	TCGA-C5-A901	CESC	TCGA	EKENS	DEG_APCC_KENBOX_2	0.0833
p.S303Y	TCGA-AA-3510	COAD	TCGA	EKENS	DEG_APCC_KENBOX_2	0.2222
p.R300M	TCGA-AD-5900	COAD	TCGA	EKENS	DEG_APCC_KENBOX_2	0.3056
p.P288H	TCGA-EE-A29E	SKCM	TCGA	EKENS	DEG_APCC_KENBOX_2	0.1389
p.P288H	DO37831	SKCM	ICGC	EKENS	DEG_APCC_KENBOX_2	0.1389
p.T306M	DO49914	CESC	ICGC	EKENS	DEG_APCC_KENBOX_2	0.1389
p.T306M	DO41235	UCEC	ICGC	EKENS	DEG_APCC_KENBOX_2	0.1389
p.K309R	DO9010	COAD	ICGC	EKENS	DEG_APCC_KENBOX_2	0.0556
p.S301Y	DO7783	COAD	ICGC	EKENS	DEG_APCC_KENBOX_2	0.2778
p.K309M	DO228574	LICA	ICGC	EKENS	DEG_APCC_KENBOX_2	0.0556
p.S299A	SIDM00193	Colorectal Carcinoma	GDSC	EKENS	DEG_APCC_KENBOX_2	0.7588
p.S299A	SNU-81	large_intestine	COSMIC	EKENS	DEG_APCC_KENBOX_2	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15014	Zinc finger protein 609	DEG_APCC_KENBOX_2	159:163	EKENS	APC,CDC20,FZR1	0.903	More...
Q13426	DNA repair protein XRCC4	DEG_APCC_KENBOX_2	295:299	EKENS	APC,CDC20,FZR1	0.9752	More...
Q2NKX8	DNA excision repair protein ERCC-6-like	DEG_APCC_KENBOX_2	976:980	EKENS	APC,CDC20,FZR1	0.9554	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_APCC_KENBOX_2	1179:1183	EKENS	APC,CDC20,FZR1	0.8074	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_APCC_KENBOX_2	621:625	EKENS	APC,CDC20,FZR1	0.766	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons