DegronMD - Q96L73(NSD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K2377T	TCGA-06-5416	GBM	TCGA	SLEKTSVPTGL	DEG_COP1_1	2374:2384	Mutation altering degron motif	0.6195
p.K2377T	SIDM01090	Colorectal Carcinoma	GDSC	SLEKTSVPTGL	DEG_COP1_1	2374:2384	Mutation altering degron motif	0.6195
p.K2377T	ACH-000943	Colon/Colorectal Cancer	CCLE	SLEKTSVPTGL	DEG_COP1_1	2374:2384	Mutation altering degron motif	0.6195
p.K2377T	RKO	large intestine	COSMIC	SLEKTSVPTGL	DEG_COP1_1	2374:2384	Mutation altering degron motif	0.6195
p.C1185F	TCGA-17-Z016	LUAD	TCGA	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.2778
p.C1185F	TCGA-S9-A6WG	LGG	TCGA	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.2778
p.P2388S	TCGA-22-5479	LUSC	TCGA	SLEKTSVPTGL	DEG_COP1_1	2374:2384	Mutation rewiring degron network	0.2222
p.E1181V	TCGA-55-7994	LUAD	TCGA	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation altering degron motif	0.7693
p.R1877H	TCGA-A5-A0G2	UCEC	TCGA	PPPY	ITCH	1867:1870	Mutation rewiring degron network	0.1389
p.E1270D	TCGA-AA-A010	COAD	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation rewiring degron network	0.0833
p.R1173C	TCGA-AN-A046	BRCA	TCGA	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.1667
p.K1249N	TCGA-AP-A0LM	UCEC	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation substituting flanking lysine	0.3056
p.A801S	TCGA-AX-A2HD	UCEC	TCGA	HKENP	DEG_APCC_KENBOX_2	794:798	Mutation rewiring degron network	0.25
p.Q2373H	TCGA-AX-A2HD	UCEC	TCGA	SLEKTSVPTGL	DEG_COP1_1	2374:2384	Mutation rewiring degron network	0.3056
p.I2394V	TCGA-BR-4201	STAD	TCGA	SLEKTSVPTGL	DEG_COP1_1	2374:2384	Mutation rewiring degron network	0.0556
p.I2394V	DO38707	STAD	ICGC	SLEKTSVPTGL	DEG_COP1_1	2374:2384	Mutation rewiring degron network	0.0556
p.I1244V	TCGA-CD-A4MG	STAD	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation rewiring degron network	0.0556
p.I274L	TCGA-D1-A103	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1111
p.I274L	DO42312	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1111
p.I1873V	TCGA-D1-A17M	UCEC	TCGA	PPPY	ITCH	1867:1870	Mutation rewiring degron network	0.25
p.N275H	TCGA-D9-A6EC	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.N275H	DO36556	READ	ICGC	PDSST	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.N275H	DO50291	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.P1251Q	TCGA-DA-A1IB	SKCM	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation rewiring degron network	0.25
p.P2624H	TCGA-DU-6392	LGG	TCGA	SRAGLWPIV	DEG_APCC_DBOX_1	2632:2640	Mutation rewiring degron network	0.1111
p.R788P	TCGA-E5-A4U1	BLCA	TCGA	HKENP	DEG_APCC_KENBOX_2	794:798	Mutation rewiring degron network	0.1667
p.P1263H	TCGA-EB-A24C	SKCM	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation rewiring degron network	0.2778
p.G2383C	TCGA-EE-A2GT	SKCM	TCGA	SLEKTSVPTGL	DEG_COP1_1	2374:2384	Mutation altering degron motif	0.76
p.M1174I	TCGA-EK-A2PG	CESC	TCGA	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.1944
p.S2623R	TCGA-EP-A2KA	LIHC	TCGA	SRAGLWPIV	DEG_APCC_DBOX_1	2632:2640	Mutation blocking phosphorylation signal	0.5278
p.K1862N	TCGA-EY-A1GI	UCEC	TCGA	PPPY	ITCH	1867:1870	Mutation substituting flanking lysine	0.3056
p.E1179D	TCGA-F5-6814	READ	TCGA	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation altering degron motif	0.5647
p.G1252E	TCGA-IB-7651	PAAD	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation rewiring degron network	0.2778
p.A1260V	TCGA-ND-A4WC	UCS	TCGA	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation altering degron motif	0.5825
p.R2633W	TCGA-ZF-AA4W	BLCA	TCGA	SRAGLWPIV	DEG_APCC_DBOX_1	2632:2640	Mutation altering degron motif	0.8634
p.R2364W	DO219089	BLCA	ICGC	SLEKTSVPTGL	DEG_COP1_1	2374:2384	Mutation blocking phosphorylation signal	0.5
p.A1181V	DO230347	COCA	ICGC	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation altering degron motif	0.6936
p.A1181V	DO40996	UCEC	ICGC	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation altering degron motif	0.6936
p.G291V	DO233140	GACA	ICGC	PDSST	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.G291V	DO233140	GACA	ICGC	PGTSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1944
p.V1862I	DO233652	GACA	ICGC	PPPY	ITCH	1867:1870	Mutation substituting flanking lysine	0.3056
p.E1251K	DO44443	HNSC	ICGC	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation rewiring degron network	0.25
p.G297E	DO52107	HNSC	ICGC	PGTSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.6087
p.S1259Y	DO52105	HNSC	ICGC	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation altering degron motif	0.712
p.R803Q	DO22237	LGG	ICGC	HKENP	DEG_APCC_KENBOX_2	794:798	Mutation rewiring degron network	0.1944
p.D1253Y	DO228985	LICA	ICGC	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation rewiring degron network	0.3056
p.G1175V	DO228986	LICA	ICGC	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.2222
p.E1173D	DO229026	LICA	ICGC	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.1667
p.G1264C	DO229034	LICA	ICGC	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation rewiring degron network	0.25
p.L282P	DO22970	LIHC	ICGC	PDSST	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7582
p.D2377N	DO52189	LIHC	ICGC	SLEKTSVPTGL	DEG_COP1_1	2374:2384	Mutation altering degron motif	0.6932
p.P1870Q	DO23810	LUAD	ICGC	PPPY	ITCH	1867:1870	Mutation altering degron motif	0.7035
p.G1191V	DO45321	LUAD	ICGC	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.1111
p.R785T	DO27120	LUSC	ICGC	HKENP	DEG_APCC_KENBOX_2	794:798	Mutation rewiring degron network	0.0833
p.T294P	DO228891	MALY	ICGC	PDSST	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1111
p.T294P	DO228891	MALY	ICGC	PGTSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.2778
p.L1861P	DO37802	SKCM	ICGC	PPPY	ITCH	1867:1870	Mutation rewiring degron network	0.1667
p.A295V	DO37432	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0833
p.A295V	DO37432	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.3056
p.D1857H	DO48765	SKCM	ICGC	PPPY	ITCH	1867:1870	Mutation rewiring degron network	0.0556
p.A309S	DO38843	STAD	ICGC	PGTSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0833
p.D1187Y	DO47769	STAD	ICGC	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.2222
p.T276M	DO43306	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1667
p.T276M	DO42472	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1667
p.R1266C	DO43642	UCEC	ICGC	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation rewiring degron network	0.1944
p.A1858V	DO42761	UCEC	ICGC	PPPY	ITCH	1867:1870	Mutation rewiring degron network	0.0833
p.W2625C	SIDM00789	Colorectal Carcinoma	GDSC	SRAGLWPIV	DEG_APCC_DBOX_1	2632:2640	Mutation rewiring degron network	0.1389
p.W2625C	ACH-000997	Colon/Colorectal Cancer	CCLE	SRAGLWPIV	DEG_APCC_DBOX_1	2632:2640	Mutation rewiring degron network	0.1389
p.W2625C	ACH-001061	Colon/Colorectal Cancer	CCLE	SRAGLWPIV	DEG_APCC_DBOX_1	2632:2640	Mutation rewiring degron network	0.1389
p.W2625C	ACH-001091	Colon/Colorectal Cancer	CCLE	SRAGLWPIV	DEG_APCC_DBOX_1	2632:2640	Mutation rewiring degron network	0.1389
p.W2625C	HCT-15	large intestine	COSMIC	SRAGLWPIV	DEG_APCC_DBOX_1	2632:2640	Mutation rewiring degron network	0.1389
p.A1260S	SIDM00924	Other Solid Cancers	GDSC	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation altering degron motif	0.6477
p.A1260S	ACH-000867	Lung Cancer	CCLE	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation altering degron motif	0.6477
p.A1260S	ChaGo-K-1	lung	COSMIC	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation altering degron motif	0.6477
p.P1170L	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.0833
p.P1170L	ACH-002301	Lymphoma	CCLE	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.0833
p.P1170L	RF-48	stomach	COSMIC	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.0833
p.T2382I	SIDM00267	Biliary Tract Carcinoma	GDSC	SLEKTSVPTGL	DEG_COP1_1	2374:2384	Mutation altering degron motif	0.8189
p.R1188S	SIDM00856	Other Solid Cancers	GDSC	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.1944
p.R1188S	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.1944
p.A2641S	SIDM01263	T-Lymphoblastic Leukemia	GDSC	SRAGLWPIV	DEG_APCC_DBOX_1	2632:2640	Mutation rewiring degron network	0.3056
p.D283V	SIDM01759	Hodgkin's Lymphoma	GDSC	PDSST	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.6674
p.M800I	ACH-000635	Ovarian Cancer	CCLE	HKENP	DEG_APCC_KENBOX_2	794:798	Mutation rewiring degron network	0.2778
p.E1859K	ACH-001100		CCLE	PPPY	ITCH	1867:1870	Mutation rewiring degron network	0.1111
p.R1861G	ACH-001645	Skin Cancer	CCLE	PPPY	ITCH	1867:1870	Mutation rewiring degron network	0.1667
p.G1267S	PF-382	haematopoietic and lymphoid tissue	COSMIC	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation rewiring degron network	0.1667
p.G1249C	SR	haematopoietic and lymphoid tissue	COSMIC	PSLTPQAE	DEG_SCF_FBW7_2	1254:1261	Mutation substituting flanking lysine	0.3056
p.N1174S	DMS-53	lung	COSMIC	EKENS	DEG_APCC_KENBOX_2	1179:1183	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NSD1

UniProt ID: Q96L73

Entrez ID: 64324

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NSD1 in