DegronMD

Uniprot ID: Q96L73

Source protein: Histone-lysine N-methyltransferase, H3 lysine-36 specific

Source gene: NSD1

Class: DEG_APCC_DBOX_1

Location: 2632:2640

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7516

ASA_SCORE: 70.5889

COIL: 0.7642

CONS_SCORE: 0.3034

DSS_SCORE: 0.2844

HELIX: 0.1021

FCONS_SCORE: 0.9005

RIG_SCORE: 0.8045

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2624H	TCGA-DU-6392	LGG	TCGA	SRAGLWPIV	DEG_APCC_DBOX_1	0.1111
p.S2623R	TCGA-EP-A2KA	LIHC	TCGA	SRAGLWPIV	DEG_APCC_DBOX_1	0.5278
p.R2633W	TCGA-ZF-AA4W	BLCA	TCGA	SRAGLWPIV	DEG_APCC_DBOX_1	0.8634
p.W2625C	SIDM00789	Colorectal Carcinoma	GDSC	SRAGLWPIV	DEG_APCC_DBOX_1	0.1389
p.W2625C	ACH-000997	Colon/Colorectal Cancer	CCLE	SRAGLWPIV	DEG_APCC_DBOX_1	0.1389
p.W2625C	ACH-001061	Colon/Colorectal Cancer	CCLE	SRAGLWPIV	DEG_APCC_DBOX_1	0.1389
p.W2625C	ACH-001091	Colon/Colorectal Cancer	CCLE	SRAGLWPIV	DEG_APCC_DBOX_1	0.1389
p.W2625C	HCT-15	large_intestine	COSMIC	SRAGLWPIV	DEG_APCC_DBOX_1	0.1389
p.A2641S	SIDM01263	T-Lymphoblastic Leukemia	GDSC	SRAGLWPIV	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_APCC_DBOX_1	2632:2640	SRAGLWPIV	APC,CDC20,FZR1	0.7516	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons